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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EIF3D
Full Name:
Eukaryotic translation initiation factor 3 subunit D
Alias:
EIF3 p66; EIF-3 zeta; EIF3d; EIF3-p66; EIF3S7; Eukaryotic translation initiation factor 3, subunit D; IF37
Type:
Translation protein, initiation complex
Mass (Da):
63973
Number AA:
548
UniProt ID:
O15371
International Prot ID:
IPI00006181
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005852
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0003743
PhosphoSite+
KinaseNET
Biological Process:
GO:0006413
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y30
E
Q
F
R
D
M
P
Y
Q
P
F
S
K
G
D
Site 2
S34
D
M
P
Y
Q
P
F
S
K
G
D
R
L
G
K
Site 3
T46
L
G
K
V
A
D
W
T
G
A
T
Y
Q
D
K
Site 4
T49
V
A
D
W
T
G
A
T
Y
Q
D
K
R
Y
T
Site 5
Y50
A
D
W
T
G
A
T
Y
Q
D
K
R
Y
T
N
Site 6
Y55
A
T
Y
Q
D
K
R
Y
T
N
K
Y
S
S
Q
Site 7
T56
T
Y
Q
D
K
R
Y
T
N
K
Y
S
S
Q
F
Site 8
Y59
D
K
R
Y
T
N
K
Y
S
S
Q
F
G
G
G
Site 9
S60
K
R
Y
T
N
K
Y
S
S
Q
F
G
G
G
S
Site 10
S61
R
Y
T
N
K
Y
S
S
Q
F
G
G
G
S
Q
Site 11
S67
S
S
Q
F
G
G
G
S
Q
Y
A
Y
F
H
E
Site 12
Y69
Q
F
G
G
G
S
Q
Y
A
Y
F
H
E
E
D
Site 13
Y71
G
G
G
S
Q
Y
A
Y
F
H
E
E
D
E
S
Site 14
S78
Y
F
H
E
E
D
E
S
S
F
Q
L
V
D
T
Site 15
S79
F
H
E
E
D
E
S
S
F
Q
L
V
D
T
A
Site 16
T85
S
S
F
Q
L
V
D
T
A
R
T
Q
K
T
A
Site 17
T91
D
T
A
R
T
Q
K
T
A
Y
Q
R
N
R
M
Site 18
Y93
A
R
T
Q
K
T
A
Y
Q
R
N
R
M
R
F
Site 19
S125
N
L
Q
I
L
P
K
S
A
K
Q
K
E
R
E
Site 20
S154
R
Q
K
W
D
Q
K
S
Q
K
P
R
D
S
S
Site 21
S160
K
S
Q
K
P
R
D
S
S
V
E
V
R
S
D
Site 22
S161
S
Q
K
P
R
D
S
S
V
E
V
R
S
D
W
Site 23
Y184
P
Q
L
M
K
M
R
Y
L
E
V
S
E
P
Q
Site 24
S188
K
M
R
Y
L
E
V
S
E
P
Q
D
I
E
C
Site 25
Y202
C
C
G
A
L
E
Y
Y
D
K
A
F
D
R
I
Site 26
T210
D
K
A
F
D
R
I
T
T
R
S
E
K
P
L
Site 27
T211
K
A
F
D
R
I
T
T
R
S
E
K
P
L
R
Site 28
S213
F
D
R
I
T
T
R
S
E
K
P
L
R
S
I
Site 29
S219
R
S
E
K
P
L
R
S
I
K
R
I
F
H
T
Site 30
T226
S
I
K
R
I
F
H
T
V
T
T
T
D
D
P
Site 31
T230
I
F
H
T
V
T
T
T
D
D
P
V
I
R
K
Site 32
S284
F
F
D
K
R
D
N
S
D
F
D
L
L
T
V
Site 33
T290
N
S
D
F
D
L
L
T
V
S
E
T
A
N
E
Site 34
S292
D
F
D
L
L
T
V
S
E
T
A
N
E
P
P
Site 35
S305
P
P
Q
D
E
G
N
S
F
N
S
P
R
N
L
Site 36
S308
D
E
G
N
S
F
N
S
P
R
N
L
A
M
E
Site 37
Y318
N
L
A
M
E
A
T
Y
I
N
H
N
F
S
Q
Site 38
Y335
L
R
M
G
K
E
R
Y
N
F
P
N
P
N
P
Site 39
S355
M
D
K
N
E
I
A
S
V
A
Y
R
Y
R
R
Site 40
Y358
N
E
I
A
S
V
A
Y
R
Y
R
R
W
K
L
Site 41
Y360
I
A
S
V
A
Y
R
Y
R
R
W
K
L
G
D
Site 42
T395
V
S
F
I
N
I
K
T
L
N
E
W
D
S
R
Site 43
S415
D
W
R
Q
K
L
D
S
Q
R
G
A
V
I
A
Site 44
Y446
A
L
L
A
G
S
E
Y
L
K
L
G
Y
V
S
Site 45
Y451
S
E
Y
L
K
L
G
Y
V
S
R
Y
H
V
K
Site 46
Y455
K
L
G
Y
V
S
R
Y
H
V
K
D
S
S
R
Site 47
S460
S
R
Y
H
V
K
D
S
S
R
H
V
I
L
G
Site 48
S461
R
Y
H
V
K
D
S
S
R
H
V
I
L
G
T
Site 49
T468
S
R
H
V
I
L
G
T
Q
Q
F
K
P
N
E
Site 50
S478
F
K
P
N
E
F
A
S
Q
I
N
L
S
V
E
Site 51
Y506
M
K
L
E
E
G
K
Y
L
I
L
K
D
P
N
Site 52
Y520
N
K
Q
V
I
R
V
Y
S
L
P
D
G
T
F
Site 53
S521
K
Q
V
I
R
V
Y
S
L
P
D
G
T
F
S
Site 54
T526
V
Y
S
L
P
D
G
T
F
S
S
D
E
D
E
Site 55
S528
S
L
P
D
G
T
F
S
S
D
E
D
E
E
E
Site 56
S529
L
P
D
G
T
F
S
S
D
E
D
E
E
E
E
Site 57
T548
E
E
E
E
E
E
E
T
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation