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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NVL
Full Name:
Nuclear valosin-containing protein-like
Alias:
Nuclear VCP-like protein; NVLp
Type:
Uncharacterized nuclear protein. AAA ATPase family.
Mass (Da):
95051
Number AA:
856
UniProt ID:
O15381
International Prot ID:
IPI00006197
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005730
GO:0043226
GO:0043227
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0017111
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y20
L
K
Q
R
V
I
Q
Y
L
T
S
N
K
C
G
Site 2
S23
R
V
I
Q
Y
L
T
S
N
K
C
G
K
Y
V
Site 3
Y29
T
S
N
K
C
G
K
Y
V
D
I
G
V
L
A
Site 4
Y43
A
S
D
L
Q
R
V
Y
S
I
D
Y
G
R
R
Site 5
S44
S
D
L
Q
R
V
Y
S
I
D
Y
G
R
R
K
Site 6
Y47
Q
R
V
Y
S
I
D
Y
G
R
R
K
R
N
A
Site 7
S64
I
Q
V
E
K
V
F
S
I
I
S
S
E
K
E
Site 8
S67
E
K
V
F
S
I
I
S
S
E
K
E
L
K
N
Site 9
S68
K
V
F
S
I
I
S
S
E
K
E
L
K
N
L
Site 10
Y96
Q
G
E
E
D
N
E
Y
T
E
S
Y
S
D
D
Site 11
T97
G
E
E
D
N
E
Y
T
E
S
Y
S
D
D
D
Site 12
S99
E
D
N
E
Y
T
E
S
Y
S
D
D
D
S
S
Site 13
S101
N
E
Y
T
E
S
Y
S
D
D
D
S
S
M
E
Site 14
S105
E
S
Y
S
D
D
D
S
S
M
E
D
Y
P
D
Site 15
S106
S
Y
S
D
D
D
S
S
M
E
D
Y
P
D
P
Site 16
Y110
D
D
S
S
M
E
D
Y
P
D
P
Q
S
A
N
Site 17
S115
E
D
Y
P
D
P
Q
S
A
N
H
M
N
S
S
Site 18
S121
Q
S
A
N
H
M
N
S
S
L
L
S
L
Y
R
Site 19
S122
S
A
N
H
M
N
S
S
L
L
S
L
Y
R
K
Site 20
S125
H
M
N
S
S
L
L
S
L
Y
R
K
G
N
P
Site 21
Y127
N
S
S
L
L
S
L
Y
R
K
G
N
P
D
S
Site 22
S134
Y
R
K
G
N
P
D
S
V
S
N
T
P
E
M
Site 23
S136
K
G
N
P
D
S
V
S
N
T
P
E
M
E
Q
Site 24
T138
N
P
D
S
V
S
N
T
P
E
M
E
Q
R
E
Site 25
T146
P
E
M
E
Q
R
E
T
T
S
S
T
P
R
I
Site 26
T147
E
M
E
Q
R
E
T
T
S
S
T
P
R
I
S
Site 27
S149
E
Q
R
E
T
T
S
S
T
P
R
I
S
S
K
Site 28
T150
Q
R
E
T
T
S
S
T
P
R
I
S
S
K
T
Site 29
S154
T
S
S
T
P
R
I
S
S
K
T
G
S
I
P
Site 30
S155
S
S
T
P
R
I
S
S
K
T
G
S
I
P
L
Site 31
T157
T
P
R
I
S
S
K
T
G
S
I
P
L
K
T
Site 32
S159
R
I
S
S
K
T
G
S
I
P
L
K
T
P
A
Site 33
T164
T
G
S
I
P
L
K
T
P
A
K
D
S
E
G
Site 34
T178
G
G
W
F
I
D
K
T
P
S
V
K
K
D
S
Site 35
S185
T
P
S
V
K
K
D
S
F
F
L
D
L
S
C
Site 36
S191
D
S
F
F
L
D
L
S
C
E
K
S
N
P
K
Site 37
S195
L
D
L
S
C
E
K
S
N
P
K
K
P
I
T
Site 38
T202
S
N
P
K
K
P
I
T
E
I
Q
D
S
K
D
Site 39
S207
P
I
T
E
I
Q
D
S
K
D
S
S
L
L
E
Site 40
S210
E
I
Q
D
S
K
D
S
S
L
L
E
S
D
M
Site 41
S211
I
Q
D
S
K
D
S
S
L
L
E
S
D
M
K
Site 42
S215
K
D
S
S
L
L
E
S
D
M
K
R
K
G
K
Site 43
S228
G
K
L
K
N
K
G
S
K
R
K
K
E
D
L
Site 44
S260
R
G
L
E
F
Q
I
S
N
V
K
F
E
D
V
Site 45
T273
D
V
G
G
N
D
M
T
L
K
E
V
C
K
M
Site 46
Y290
H
M
R
H
P
E
V
Y
H
H
L
G
V
V
P
Site 47
S355
E
L
F
E
Q
A
V
S
N
A
P
C
I
I
F
Site 48
T370
I
D
E
I
D
A
I
T
P
K
R
E
V
A
S
Site 49
T410
R
V
L
V
I
G
A
T
N
R
P
D
S
L
D
Site 50
S415
G
A
T
N
R
P
D
S
L
D
P
A
L
R
R
Site 51
S439
L
G
I
P
D
E
A
S
R
E
R
I
L
Q
T
Site 52
T446
S
R
E
R
I
L
Q
T
L
C
R
K
L
R
L
Site 53
S508
P
E
M
E
D
L
P
S
K
G
V
Q
E
E
R
Site 54
T518
V
Q
E
E
R
L
G
T
E
P
T
S
E
T
Q
Site 55
S522
R
L
G
T
E
P
T
S
E
T
Q
D
E
L
Q
Site 56
S542
L
R
D
Q
D
P
L
S
E
E
Q
M
Q
G
L
Site 57
S566
A
L
S
S
V
Q
P
S
A
K
R
E
G
F
V
Site 58
T574
A
K
R
E
G
F
V
T
V
P
N
V
T
W
A
Site 59
Y655
G
P
E
L
L
N
M
Y
V
G
E
S
E
R
A
Site 60
S659
L
N
M
Y
V
G
E
S
E
R
A
V
R
Q
V
Site 61
S691
D
A
L
C
P
R
R
S
D
R
E
T
G
A
S
Site 62
T695
P
R
R
S
D
R
E
T
G
A
S
V
R
V
V
Site 63
S698
S
D
R
E
T
G
A
S
V
R
V
V
N
Q
L
Site 64
T743
R
P
G
R
L
D
K
T
L
F
V
G
L
P
P
Site 65
T760
D
R
L
A
I
L
K
T
I
T
K
N
G
T
K
Site 66
Y788
G
D
L
R
C
D
C
Y
T
G
A
D
L
S
A
Site 67
S801
S
A
L
V
R
E
A
S
I
C
A
L
R
Q
E
Site 68
S814
Q
E
M
A
R
Q
K
S
G
N
E
K
G
E
L
Site 69
S824
E
K
G
E
L
K
V
S
H
K
H
F
E
E
A
Site 70
S837
E
A
F
K
K
V
R
S
S
I
S
K
K
D
Q
Site 71
S838
A
F
K
K
V
R
S
S
I
S
K
K
D
Q
I
Site 72
S840
K
K
V
R
S
S
I
S
K
K
D
Q
I
M
Y
Site 73
Y847
S
K
K
D
Q
I
M
Y
E
R
L
Q
E
S
L
Site 74
S855
E
R
L
Q
E
S
L
S
R
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation