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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NMDAR2D
Full Name:
Glutamate [NMDA] receptor subunit epsilon-4
Alias:
EB11; Estrogen receptor binding CpG island; Glutamate receptor, ionotropic, N-methyl D-aspartate 2D; GRIN2D; NMDE4; N-methyl D-aspartate receptor 2D; NR2D
Type:
Plasma membrane, Postsynaptic membrane, Synapse, Synaptosome, Cell junction, Integral membrane protein
Mass (Da):
143752
Number AA:
1336
UniProt ID:
O15399
International Prot ID:
IPI00006217
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030054
GO:0045211
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0005234
GO:0000287
PhosphoSite+
KinaseNET
Biological Process:
GO:0006811
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S98
L
N
G
S
D
P
R
S
L
V
L
Q
L
C
D
Site 2
T153
G
G
A
A
L
V
L
T
P
K
E
K
G
S
T
Site 3
T160
T
P
K
E
K
G
S
T
F
L
Q
L
G
S
S
Site 4
S167
T
F
L
Q
L
G
S
S
T
E
Q
Q
L
Q
V
Site 5
S186
L
E
E
Y
D
W
T
S
F
V
A
V
T
T
R
Site 6
T191
W
T
S
F
V
A
V
T
T
R
A
P
G
H
R
Site 7
S211
I
E
V
L
T
D
G
S
L
V
G
W
E
H
R
Site 8
T222
W
E
H
R
G
A
L
T
L
D
P
G
A
G
E
Site 9
S285
Q
L
A
G
G
G
G
S
G
A
P
G
E
P
P
Site 10
T354
D
C
R
A
Q
N
R
T
H
R
G
E
S
L
H
Site 11
Y363
R
G
E
S
L
H
R
Y
F
M
N
I
T
W
D
Site 12
Y374
I
T
W
D
N
R
D
Y
S
F
N
E
D
G
F
Site 13
S391
N
P
S
L
V
V
I
S
L
T
R
D
R
T
W
Site 14
T397
I
S
L
T
R
D
R
T
W
E
V
V
G
S
W
Site 15
S403
R
T
W
E
V
V
G
S
W
E
Q
Q
T
L
R
Site 16
T408
V
G
S
W
E
Q
Q
T
L
R
L
K
Y
P
L
Site 17
Y413
Q
Q
T
L
R
L
K
Y
P
L
W
S
R
Y
G
Site 18
Y419
K
Y
P
L
W
S
R
Y
G
R
F
L
Q
P
V
Site 19
T429
F
L
Q
P
V
D
D
T
Q
H
L
T
V
A
T
Site 20
T433
V
D
D
T
Q
H
L
T
V
A
T
L
E
E
R
Site 21
S452
V
E
P
A
D
P
I
S
G
T
C
I
R
D
S
Site 22
S459
S
G
T
C
I
R
D
S
V
P
C
R
S
Q
L
Site 23
S464
R
D
S
V
P
C
R
S
Q
L
N
R
T
H
S
Site 24
T469
C
R
S
Q
L
N
R
T
H
S
P
P
P
D
A
Site 25
S471
S
Q
L
N
R
T
H
S
P
P
P
D
A
P
R
Site 26
Y506
I
G
F
S
Y
D
L
Y
L
V
T
N
G
K
H
Site 27
S539
R
A
D
M
A
I
G
S
L
T
I
N
E
E
R
Site 28
S573
A
R
S
N
G
T
V
S
P
S
A
F
L
E
P
Site 29
S575
S
N
G
T
V
S
P
S
A
F
L
E
P
Y
S
Site 30
Y612
E
Y
L
S
P
V
G
Y
N
R
S
L
A
T
G
Site 31
S615
S
P
V
G
Y
N
R
S
L
A
T
G
K
R
P
Site 32
S625
T
G
K
R
P
G
G
S
T
F
T
I
G
K
S
Site 33
T626
G
K
R
P
G
G
S
T
F
T
I
G
K
S
I
Site 34
T628
R
P
G
G
S
T
F
T
I
G
K
S
I
W
L
Site 35
S644
W
A
L
V
F
N
N
S
V
P
V
E
N
P
R
Site 36
T653
P
V
E
N
P
R
G
T
T
S
K
I
M
V
L
Site 37
T689
I
Q
E
E
Y
V
D
T
V
S
G
L
S
D
R
Site 38
S694
V
D
T
V
S
G
L
S
D
R
K
F
Q
R
P
Site 39
Y705
F
Q
R
P
Q
E
Q
Y
P
P
L
K
F
G
T
Site 40
T712
Y
P
P
L
K
F
G
T
V
P
N
G
S
T
E
Site 41
S717
F
G
T
V
P
N
G
S
T
E
K
N
I
R
S
Site 42
S724
S
T
E
K
N
I
R
S
N
Y
P
D
M
H
S
Site 43
Y726
E
K
N
I
R
S
N
Y
P
D
M
H
S
Y
M
Site 44
Y732
N
Y
P
D
M
H
S
Y
M
V
R
Y
N
Q
P
Site 45
Y736
M
H
S
Y
M
V
R
Y
N
Q
P
R
V
E
E
Site 46
T746
P
R
V
E
E
A
L
T
Q
L
K
A
G
K
L
Site 47
S797
G
I
A
L
H
K
G
S
R
W
K
R
P
I
D
Site 48
S838
D
K
I
E
V
M
S
S
K
L
D
I
D
N
M
Site 49
S917
P
P
P
Q
P
L
P
S
P
A
Y
P
A
P
R
Site 50
Y920
Q
P
L
P
S
P
A
Y
P
A
P
R
P
A
P
Site 51
S939
F
V
P
R
E
R
A
S
V
D
R
W
R
R
T
Site 52
T946
S
V
D
R
W
R
R
T
K
G
A
G
P
P
G
Site 53
Y964
L
A
D
G
F
H
R
Y
Y
G
P
I
E
P
Q
Site 54
Y965
A
D
G
F
H
R
Y
Y
G
P
I
E
P
Q
G
Site 55
S993
G
A
A
G
R
P
L
S
P
P
A
A
Q
P
P
Site 56
S1006
P
P
Q
K
P
P
P
S
Y
F
A
I
V
R
D
Site 57
Y1007
P
Q
K
P
P
P
S
Y
F
A
I
V
R
D
K
Site 58
S1054
R
L
A
F
E
D
E
S
P
P
A
P
A
R
W
Site 59
S1064
A
P
A
R
W
P
R
S
D
P
E
S
Q
P
L
Site 60
S1068
W
P
R
S
D
P
E
S
Q
P
L
L
G
P
G
Site 61
Y1105
A
A
P
P
P
C
P
Y
L
D
L
E
P
S
P
Site 62
S1111
P
Y
L
D
L
E
P
S
P
S
D
S
E
D
S
Site 63
S1113
L
D
L
E
P
S
P
S
D
S
E
D
S
E
S
Site 64
S1115
L
E
P
S
P
S
D
S
E
D
S
E
S
L
G
Site 65
S1118
S
P
S
D
S
E
D
S
E
S
L
G
G
A
S
Site 66
S1120
S
D
S
E
D
S
E
S
L
G
G
A
S
L
G
Site 67
S1125
S
E
S
L
G
G
A
S
L
G
G
L
E
P
W
Site 68
Y1141
F
A
D
F
P
Y
P
Y
A
E
R
L
G
P
P
Site 69
Y1152
L
G
P
P
P
G
R
Y
W
S
V
D
K
L
G
Site 70
S1154
P
P
P
G
R
Y
W
S
V
D
K
L
G
G
W
Site 71
S1165
L
G
G
W
R
A
G
S
W
D
Y
L
P
P
R
Site 72
Y1168
W
R
A
G
S
W
D
Y
L
P
P
R
S
G
P
Site 73
S1196
L
P
P
P
R
H
L
S
C
S
H
D
G
L
D
Site 74
S1198
P
P
R
H
L
S
C
S
H
D
G
L
D
G
G
Site 75
S1231
A
R
C
G
C
P
R
S
H
P
H
R
P
R
A
Site 76
S1239
H
P
H
R
P
R
A
S
H
R
T
P
A
A
A
Site 77
T1242
R
P
R
A
S
H
R
T
P
A
A
A
A
P
H
Site 78
S1269
L
P
P
P
A
P
T
S
R
S
L
E
D
L
S
Site 79
S1271
P
P
A
P
T
S
R
S
L
E
D
L
S
S
C
Site 80
S1276
S
R
S
L
E
D
L
S
S
C
P
R
A
A
P
Site 81
S1277
R
S
L
E
D
L
S
S
C
P
R
A
A
P
A
Site 82
T1288
A
A
P
A
R
R
L
T
G
P
S
R
H
A
R
Site 83
S1291
A
R
R
L
T
G
P
S
R
H
A
R
R
C
P
Site 84
S1311
G
P
P
L
P
T
A
S
H
R
R
H
R
G
G
Site 85
T1322
H
R
G
G
D
L
G
T
R
R
G
S
A
H
F
Site 86
S1326
D
L
G
T
R
R
G
S
A
H
F
S
S
L
E
Site 87
S1330
R
R
G
S
A
H
F
S
S
L
E
S
E
V
_
Site 88
S1331
R
G
S
A
H
F
S
S
L
E
S
E
V
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation