KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
ABCC3
Full Name:
Canalicular multispecific organic anion transporter 2
Alias:
ABC31; ATP-binding cassette sub-family C member 3; ATP-binding cassette, sub-family C (CFTR/MRP) member 3; CMOAT2; EST90757; MLP2; MOAT-D; MRP3; Multidrug resistance-associated 3; Multi-specific organic anion transporter-D
Type:
Transporter
Mass (Da):
169343
Number AA:
1527
UniProt ID:
O15438
International Prot ID:
IPI00251066
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
GO:0005624
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0042626
GO:0008514
PhosphoSite+
KinaseNET
Biological Process:
GO:0055085
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
C
G
S
G
E
L
G
S
K
F
W
D
S
N
L
Site 2
S17
L
G
S
K
F
W
D
S
N
L
S
V
H
T
E
Site 3
S20
K
F
W
D
S
N
L
S
V
H
T
E
N
P
D
Site 4
T29
H
T
E
N
P
D
L
T
P
C
F
Q
N
S
L
Site 5
Y63
L
R
H
H
C
R
G
Y
I
I
L
S
H
L
S
Site 6
S166
A
K
A
E
G
E
I
S
D
P
F
R
F
T
T
Site 7
Y207
K
N
V
D
P
N
P
Y
P
E
T
S
A
G
F
Site 8
T210
D
P
N
P
Y
P
E
T
S
A
G
F
L
S
R
Site 9
S211
P
N
P
Y
P
E
T
S
A
G
F
L
S
R
L
Site 10
Y229
W
F
T
K
M
A
I
Y
G
Y
R
H
P
L
E
Site 11
Y231
T
K
M
A
I
Y
G
Y
R
H
P
L
E
E
K
Site 12
S242
L
E
E
K
D
L
W
S
L
K
E
E
D
R
S
Site 13
S249
S
L
K
E
E
D
R
S
Q
M
V
V
Q
Q
L
Site 14
S281
A
A
P
G
K
N
A
S
G
E
D
E
V
L
L
Site 15
S298
R
P
R
P
R
K
P
S
F
L
K
A
L
L
A
Site 16
S404
T
N
S
V
K
R
A
S
T
V
G
E
I
V
N
Site 17
T405
N
S
V
K
R
A
S
T
V
G
E
I
V
N
L
Site 18
S486
K
Q
M
K
L
K
D
S
R
I
K
L
M
S
E
Site 19
S492
D
S
R
I
K
L
M
S
E
I
L
N
G
I
K
Site 20
S509
K
L
Y
A
W
E
P
S
F
L
K
Q
V
E
G
Site 21
T593
P
Q
L
I
S
N
L
T
Q
A
S
V
S
L
K
Site 22
S598
N
L
T
Q
A
S
V
S
L
K
R
I
Q
Q
F
Site 23
S607
K
R
I
Q
Q
F
L
S
Q
E
E
L
D
P
Q
Site 24
S615
Q
E
E
L
D
P
Q
S
V
E
R
K
T
I
S
Site 25
T620
P
Q
S
V
E
R
K
T
I
S
P
G
Y
A
I
Site 26
S622
S
V
E
R
K
T
I
S
P
G
Y
A
I
T
I
Site 27
Y625
R
K
T
I
S
P
G
Y
A
I
T
I
H
S
G
Site 28
T635
T
I
H
S
G
T
F
T
W
A
Q
D
L
P
P
Site 29
T643
W
A
Q
D
L
P
P
T
L
H
S
L
D
I
Q
Site 30
S690
G
K
V
H
M
K
G
S
V
A
Y
V
P
Q
Q
Site 31
Y693
H
M
K
G
S
V
A
Y
V
P
Q
Q
A
W
I
Site 32
T742
M
L
P
G
G
D
Q
T
E
I
G
E
K
G
I
Site 33
S752
G
E
K
G
I
N
L
S
G
G
Q
R
Q
R
V
Site 34
S760
G
G
Q
R
Q
R
V
S
L
A
R
A
V
Y
S
Site 35
Y835
Q
V
S
E
M
G
P
Y
P
A
L
L
Q
R
N
Site 36
Y852
F
A
N
F
L
C
N
Y
A
P
D
E
D
Q
G
Site 37
S864
D
Q
G
H
L
E
D
S
W
T
A
L
E
G
A
Site 38
T866
G
H
L
E
D
S
W
T
A
L
E
G
A
E
D
Site 39
T882
E
A
L
L
I
E
D
T
L
S
N
H
T
D
L
Site 40
S884
L
L
I
E
D
T
L
S
N
H
T
D
L
T
D
Site 41
T890
L
S
N
H
T
D
L
T
D
N
D
P
V
T
Y
Site 42
T896
L
T
D
N
D
P
V
T
Y
V
V
Q
K
Q
F
Site 43
Y897
T
D
N
D
P
V
T
Y
V
V
Q
K
Q
F
M
Site 44
S908
K
Q
F
M
R
Q
L
S
A
L
S
S
D
G
E
Site 45
S911
M
R
Q
L
S
A
L
S
S
D
G
E
G
Q
G
Site 46
S912
R
Q
L
S
A
L
S
S
D
G
E
G
Q
G
R
Site 47
S929
P
R
R
H
L
G
P
S
E
K
V
Q
V
T
E
Site 48
S1003
T
N
D
A
M
A
D
S
R
Q
N
N
T
S
L
Site 49
S1009
D
S
R
Q
N
N
T
S
L
R
L
G
V
Y
A
Site 50
S1055
L
L
H
N
K
I
R
S
P
Q
S
F
F
D
T
Site 51
S1058
N
K
I
R
S
P
Q
S
F
F
D
T
T
P
S
Site 52
T1062
S
P
Q
S
F
F
D
T
T
P
S
G
R
I
L
Site 53
T1063
P
Q
S
F
F
D
T
T
P
S
G
R
I
L
N
Site 54
Y1129
Y
T
L
V
Q
R
F
Y
A
A
T
S
R
Q
L
Site 55
T1132
V
Q
R
F
Y
A
A
T
S
R
Q
L
K
R
L
Site 56
S1141
R
Q
L
K
R
L
E
S
V
S
R
S
P
I
Y
Site 57
S1143
L
K
R
L
E
S
V
S
R
S
P
I
Y
S
H
Site 58
S1145
R
L
E
S
V
S
R
S
P
I
Y
S
H
F
S
Site 59
Y1148
S
V
S
R
S
P
I
Y
S
H
F
S
E
T
V
Site 60
S1149
V
S
R
S
P
I
Y
S
H
F
S
E
T
V
T
Site 61
S1152
S
P
I
Y
S
H
F
S
E
T
V
T
G
A
S
Site 62
Y1164
G
A
S
V
I
R
A
Y
N
R
S
R
D
F
E
Site 63
S1167
V
I
R
A
Y
N
R
S
R
D
F
E
I
I
S
Site 64
S1174
S
R
D
F
E
I
I
S
D
T
K
V
D
A
N
Site 65
T1176
D
F
E
I
I
S
D
T
K
V
D
A
N
Q
R
Site 66
Y1186
D
A
N
Q
R
S
C
Y
P
Y
I
I
S
N
R
Site 67
Y1188
N
Q
R
S
C
Y
P
Y
I
I
S
N
R
W
L
Site 68
S1248
N
W
M
I
R
M
M
S
D
L
E
S
N
I
V
Site 69
S1252
R
M
M
S
D
L
E
S
N
I
V
A
V
E
R
Site 70
S1264
V
E
R
V
K
E
Y
S
K
T
E
T
E
A
P
Site 71
T1266
R
V
K
E
Y
S
K
T
E
T
E
A
P
W
V
Site 72
T1268
K
E
Y
S
K
T
E
T
E
A
P
W
V
V
E
Site 73
S1277
A
P
W
V
V
E
G
S
R
P
P
E
G
W
P
Site 74
Y1294
G
E
V
E
F
R
N
Y
S
V
R
Y
R
P
G
Site 75
S1295
E
V
E
F
R
N
Y
S
V
R
Y
R
P
G
L
Site 76
S1310
D
L
V
L
R
D
L
S
L
H
V
H
G
G
E
Site 77
T1367
H
D
L
R
S
Q
L
T
I
I
P
Q
D
P
I
Site 78
S1377
P
Q
D
P
I
L
F
S
G
T
L
R
M
N
L
Site 79
T1379
D
P
I
L
F
S
G
T
L
R
M
N
L
D
P
Site 80
S1389
M
N
L
D
P
F
G
S
Y
S
E
E
D
I
W
Site 81
T1406
L
E
L
S
H
L
H
T
F
V
S
S
Q
P
A
Site 82
S1409
S
H
L
H
T
F
V
S
S
Q
P
A
G
L
D
Site 83
S1410
H
L
H
T
F
V
S
S
Q
P
A
G
L
D
F
Site 84
S1420
A
G
L
D
F
Q
C
S
E
G
G
E
N
L
S
Site 85
S1427
S
E
G
G
E
N
L
S
V
G
Q
R
Q
L
V
Site 86
T1470
L
I
Q
A
T
I
R
T
Q
F
D
T
C
T
V
Site 87
T1476
R
T
Q
F
D
T
C
T
V
L
T
I
A
H
R
Site 88
T1486
T
I
A
H
R
L
N
T
I
M
D
Y
T
R
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation