PhosphoNET

           
Protein Info 
   
Short Name:  TLR3
Full Name:  Toll-like receptor 3
Alias:  CD283; CD283 antigen; Toll-like receptor 3; Toll-like receptor 3 precursor
Type:  Receptor, cytokine
Mass (Da):  103829
Number AA:  904
UniProt ID:  O15455
International Prot ID:  IPI00019007
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005783  GO:0010008  GO:0005887 Uniprot OncoNet
Molecular Function:  GO:0003725  GO:0005515  GO:0004888 PhosphoSite+ KinaseNET
Biological Process:  GO:0007252  GO:0007250  GO:0042742 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1T29ASSTTKCTVSHEVAD
Site 2S31STTKCTVSHEVADCS
Site 3S38SHEVADCSHLKLTQV
Site 4T43DCSHLKLTQVPDDLP
Site 5T54DDLPTNITVLNLTHN
Site 6S75AANFTRYSQLTSLDV
Site 7T78FTRYSQLTSLDVGFN
Site 8S79TRYSQLTSLDVGFNT
Site 9S112NLQHNELSQLSDKTF
Site 10T151VKQKNLITLDLSHNG
Site 11S155NLITLDLSHNGLSST
Site 12S161LSHNGLSSTKLGTQV
Site 13S179NLQELLLSNNKIQAL
Site 14S188NKIQALKSEELDIFA
Site 15S197ELDIFANSSLKKLEL
Site 16S205SLKKLELSSNQIKEF
Site 17S206LKKLELSSNQIKEFS
Site 18S213SNQIKEFSPGCFHAI
Site 19S254NTSIRNLSLSNSQLS
Site 20S256SIRNLSLSNSQLSTT
Site 21S258RNLSLSNSQLSTTSN
Site 22S261SLSNSQLSTTSNTTF
Site 23T262LSNSQLSTTSNTTFL
Site 24S264NSQLSTTSNTTFLGL
Site 25T277GLKWTNLTMLDLSYN
Site 26Y302AWLPQLEYFFLEYNN
Site 27Y326HGLFNVRYLNLKRSF
Site 28S332RYLNLKRSFTKQSIS
Site 29T334LNLKRSFTKQSISLA
Site 30S337KRSFTKQSISLASLP
Site 31S342KQSISLASLPKIDDF
Site 32S350LPKIDDFSFQWLKCL
Site 33Y383TGLINLKYLSLSNSF
Site 34S387NLKYLSLSNSFTSLR
Site 35S389KYLSLSNSFTSLRTL
Site 36T391LSLSNSFTSLRTLTN
Site 37S392SLSNSFTSLRTLTNE
Site 38T400LRTLTNETFVSLAHS
Site 39T415PLHILNLTKNKISKI
Site 40S420NLTKNKISKIESDAF
Site 41S424NKISKIESDAFSWLG
Site 42S428KIESDAFSWLGHLEV
Site 43Y462LENIFEIYLSYNKYL
Site 44Y468IYLSYNKYLQLTRNS
Site 45S497VALKNVDSSPSPFQP
Site 46S498ALKNVDSSPSPFQPL
Site 47S500KNVDSSPSPFQPLRN
Site 48T509FQPLRNLTILDLSNN
Site 49Y556ANPGGPIYFLKGLSH
Site 50S604NLNTLPASVFNNQVS
Site 51S611SVFNNQVSLKSLNLQ
Site 52S614NNQVSLKSLNLQKNL
Site 53T638GPAFRNLTELDMRFN
Site 54T666NWINETHTNIPELSS
Site 55Y675IPELSSHYLCNTPPH
Site 56T679SSHYLCNTPPHYHGF
Site 57Y683LCNTPPHYHGFPVRL
Site 58T693FPVRLFDTSSCKDSA
Site 59S694PVRLFDTSSCKDSAP
Site 60S695VRLFDTSSCKDSAPF
Site 61S699DTSSCKDSAPFELFF
Site 62T751FKEIDRQTEQFEYAA
Site 63Y756RQTEQFEYAAYIIHA
Site 64Y759EQFEYAAYIIHAYKD
Site 65S783SMEKEDQSLKFCLEE
Site 66S806ELEAIVNSIKRSRKI
Site 67T818RKIIFVITHHLLKDP
Site 68Y858FLEEIPDYKLNHALC
Site 69S899KLQVALGSKNSVH__
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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