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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MSH4
Full Name:
MutS protein homolog 4
Alias:
mutS 4
Type:
DNA binding protein
Mass (Da):
104756
Number AA:
936
UniProt ID:
O15457
International Prot ID:
IPI00289914
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0030983
PhosphoSite+
KinaseNET
Biological Process:
GO:0006298
GO:0007131
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
L
R
P
E
I
S
S
T
S
P
S
A
P
Site 2
S8
M
L
R
P
E
I
S
S
T
S
P
S
A
P
A
Site 3
T9
L
R
P
E
I
S
S
T
S
P
S
A
P
A
V
Site 4
S10
R
P
E
I
S
S
T
S
P
S
A
P
A
V
S
Site 5
S12
E
I
S
S
T
S
P
S
A
P
A
V
S
P
S
Site 6
S17
S
P
S
A
P
A
V
S
P
S
S
G
E
T
R
Site 7
S19
S
A
P
A
V
S
P
S
S
G
E
T
R
S
P
Site 8
S20
A
P
A
V
S
P
S
S
G
E
T
R
S
P
Q
Site 9
T23
V
S
P
S
S
G
E
T
R
S
P
Q
G
P
R
Site 10
S25
P
S
S
G
E
T
R
S
P
Q
G
P
R
Y
N
Site 11
Y31
R
S
P
Q
G
P
R
Y
N
F
G
L
Q
E
T
Site 12
T38
Y
N
F
G
L
Q
E
T
P
Q
S
R
P
S
V
Site 13
S41
G
L
Q
E
T
P
Q
S
R
P
S
V
Q
V
V
Site 14
S44
E
T
P
Q
S
R
P
S
V
Q
V
V
S
A
S
Site 15
S49
R
P
S
V
Q
V
V
S
A
S
T
C
P
G
T
Site 16
S64
S
G
A
A
G
D
R
S
S
S
S
S
S
L
P
Site 17
S65
G
A
A
G
D
R
S
S
S
S
S
S
L
P
C
Site 18
S66
A
A
G
D
R
S
S
S
S
S
S
L
P
C
P
Site 19
S67
A
G
D
R
S
S
S
S
S
S
L
P
C
P
A
Site 20
S68
G
D
R
S
S
S
S
S
S
L
P
C
P
A
P
Site 21
S69
D
R
S
S
S
S
S
S
L
P
C
P
A
P
N
Site 22
S77
L
P
C
P
A
P
N
S
R
P
A
Q
G
S
Y
Site 23
S83
N
S
R
P
A
Q
G
S
Y
F
G
N
K
R
A
Site 24
Y84
S
R
P
A
Q
G
S
Y
F
G
N
K
R
A
Y
Site 25
Y91
Y
F
G
N
K
R
A
Y
A
E
N
T
V
A
S
Site 26
T95
K
R
A
Y
A
E
N
T
V
A
S
N
F
T
F
Site 27
S98
Y
A
E
N
T
V
A
S
N
F
T
F
G
A
S
Site 28
T101
N
T
V
A
S
N
F
T
F
G
A
S
S
S
S
Site 29
S106
N
F
T
F
G
A
S
S
S
S
A
R
D
T
N
Site 30
S107
F
T
F
G
A
S
S
S
S
A
R
D
T
N
Y
Site 31
S108
T
F
G
A
S
S
S
S
A
R
D
T
N
Y
P
Site 32
T112
S
S
S
S
A
R
D
T
N
Y
P
Q
T
L
K
Site 33
Y114
S
S
A
R
D
T
N
Y
P
Q
T
L
K
T
P
Site 34
T117
R
D
T
N
Y
P
Q
T
L
K
T
P
L
S
T
Site 35
T120
N
Y
P
Q
T
L
K
T
P
L
S
T
G
N
P
Site 36
S123
Q
T
L
K
T
P
L
S
T
G
N
P
Q
R
S
Site 37
S130
S
T
G
N
P
Q
R
S
G
Y
K
S
W
T
P
Site 38
Y132
G
N
P
Q
R
S
G
Y
K
S
W
T
P
Q
V
Site 39
S134
P
Q
R
S
G
Y
K
S
W
T
P
Q
V
G
Y
Site 40
T136
R
S
G
Y
K
S
W
T
P
Q
V
G
Y
S
A
Site 41
Y141
S
W
T
P
Q
V
G
Y
S
A
S
S
S
S
A
Site 42
S142
W
T
P
Q
V
G
Y
S
A
S
S
S
S
A
I
Site 43
S144
P
Q
V
G
Y
S
A
S
S
S
S
A
I
S
A
Site 44
S145
Q
V
G
Y
S
A
S
S
S
S
A
I
S
A
H
Site 45
S146
V
G
Y
S
A
S
S
S
S
A
I
S
A
H
S
Site 46
S147
G
Y
S
A
S
S
S
S
A
I
S
A
H
S
P
Site 47
S186
K
N
P
Q
I
I
L
S
Q
F
A
D
N
T
T
Site 48
T193
S
Q
F
A
D
N
T
T
Y
A
K
V
I
T
K
Site 49
Y194
Q
F
A
D
N
T
T
Y
A
K
V
I
T
K
L
Site 50
Y244
F
T
T
I
Q
R
K
Y
F
N
E
T
K
G
L
Site 51
Y294
E
F
I
Q
N
S
V
Y
A
P
K
S
L
K
I
Site 52
S298
N
S
V
Y
A
P
K
S
L
K
I
C
F
Q
G
Site 53
S315
Q
T
A
M
I
D
S
S
S
A
Q
N
L
E
L
Site 54
Y329
L
L
I
N
N
Q
D
Y
R
N
N
H
T
L
F
Site 55
T334
Q
D
Y
R
N
N
H
T
L
F
G
V
L
N
Y
Site 56
T342
L
F
G
V
L
N
Y
T
K
T
P
G
G
S
R
Site 57
T344
G
V
L
N
Y
T
K
T
P
G
G
S
R
R
L
Site 58
S348
Y
T
K
T
P
G
G
S
R
R
L
R
S
N
I
Site 59
S353
G
G
S
R
R
L
R
S
N
I
L
E
P
L
V
Site 60
T410
V
Q
I
P
K
Q
D
T
V
N
A
A
E
S
K
Site 61
T419
N
A
A
E
S
K
I
T
N
L
I
Y
L
K
H
Site 62
T443
I
A
M
K
N
C
N
T
P
L
L
R
A
Y
Y
Site 63
Y449
N
T
P
L
L
R
A
Y
Y
G
S
L
E
D
K
Site 64
Y450
T
P
L
L
R
A
Y
Y
G
S
L
E
D
K
R
Site 65
S452
L
L
R
A
Y
Y
G
S
L
E
D
K
R
F
G
Site 66
Y475
V
I
N
D
D
A
R
Y
M
K
G
C
L
N
M
Site 67
Y488
N
M
R
T
Q
K
C
Y
A
V
R
S
N
I
N
Site 68
T504
F
L
D
I
A
R
R
T
Y
T
E
I
V
D
D
Site 69
Y505
L
D
I
A
R
R
T
Y
T
E
I
V
D
D
I
Site 70
T506
D
I
A
R
R
T
Y
T
E
I
V
D
D
I
A
Site 71
S517
D
D
I
A
G
M
I
S
Q
L
G
E
K
Y
S
Site 72
Y523
I
S
Q
L
G
E
K
Y
S
L
P
L
R
T
S
Site 73
S524
S
Q
L
G
E
K
Y
S
L
P
L
R
T
S
F
Site 74
S530
Y
S
L
P
L
R
T
S
F
S
S
A
R
G
F
Site 75
S533
P
L
R
T
S
F
S
S
A
R
G
F
F
I
Q
Site 76
S550
T
D
C
I
A
L
P
S
D
Q
L
P
S
E
F
Site 77
S555
L
P
S
D
Q
L
P
S
E
F
I
K
I
S
K
Site 78
S561
P
S
E
F
I
K
I
S
K
V
K
N
S
Y
S
Site 79
S566
K
I
S
K
V
K
N
S
Y
S
F
T
S
A
D
Site 80
S568
S
K
V
K
N
S
Y
S
F
T
S
A
D
L
I
Site 81
T570
V
K
N
S
Y
S
F
T
S
A
D
L
I
K
M
Site 82
Y589
Q
E
S
L
R
E
I
Y
H
M
T
Y
M
I
V
Site 83
Y635
H
A
C
T
L
S
D
Y
V
R
P
E
F
T
D
Site 84
T643
V
R
P
E
F
T
D
T
L
A
I
K
Q
G
W
Site 85
T667
E
K
P
I
A
N
N
T
Y
V
T
E
G
S
N
Site 86
Y668
K
P
I
A
N
N
T
Y
V
T
E
G
S
N
F
Site 87
T679
G
S
N
F
L
I
I
T
G
P
N
M
S
G
K
Site 88
S684
I
I
T
G
P
N
M
S
G
K
S
T
Y
L
K
Site 89
S687
G
P
N
M
S
G
K
S
T
Y
L
K
Q
I
A
Site 90
T688
P
N
M
S
G
K
S
T
Y
L
K
Q
I
A
L
Site 91
S712
Y
V
P
A
E
Y
S
S
F
R
I
A
K
Q
I
Site 92
S724
K
Q
I
F
T
R
I
S
T
D
D
D
I
E
T
Site 93
T725
Q
I
F
T
R
I
S
T
D
D
D
I
E
T
N
Site 94
T731
S
T
D
D
D
I
E
T
N
S
S
T
F
M
K
Site 95
S733
D
D
D
I
E
T
N
S
S
T
F
M
K
E
M
Site 96
S734
D
D
I
E
T
N
S
S
T
F
M
K
E
M
K
Site 97
T735
D
I
E
T
N
S
S
T
F
M
K
E
M
K
E
Site 98
S754
L
H
N
A
N
D
K
S
L
I
L
I
D
E
L
Site 99
T765
I
D
E
L
G
R
G
T
N
T
E
E
G
I
G
Site 100
T767
E
L
G
R
G
T
N
T
E
E
G
I
G
I
C
Site 101
Y804
L
C
H
I
D
A
L
Y
P
N
V
E
N
M
H
Site 102
Y829
R
N
K
E
A
I
L
Y
T
Y
K
L
S
K
G
Site 103
T838
Y
K
L
S
K
G
L
T
E
E
K
N
Y
G
L
Site 104
Y843
G
L
T
E
E
K
N
Y
G
L
K
A
A
E
V
Site 105
S856
E
V
S
S
L
P
P
S
I
V
L
D
A
K
E
Site 106
T865
V
L
D
A
K
E
I
T
T
Q
I
T
R
Q
I
Site 107
S878
Q
I
L
Q
N
Q
R
S
T
P
E
M
E
R
Q
Site 108
T879
I
L
Q
N
Q
R
S
T
P
E
M
E
R
Q
R
Site 109
Y889
M
E
R
Q
R
A
V
Y
H
L
A
T
R
L
V
Site 110
T898
L
A
T
R
L
V
Q
T
A
R
N
S
Q
L
D
Site 111
S902
L
V
Q
T
A
R
N
S
Q
L
D
P
D
S
L
Site 112
S908
N
S
Q
L
D
P
D
S
L
R
I
Y
L
S
N
Site 113
Y912
D
P
D
S
L
R
I
Y
L
S
N
L
K
K
K
Site 114
S914
D
S
L
R
I
Y
L
S
N
L
K
K
K
Y
K
Site 115
Y920
L
S
N
L
K
K
K
Y
K
E
D
F
P
R
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation