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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
P4HA2
Full Name:
Prolyl 4-hydroxylase subunit alpha-2
Alias:
Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-2
Type:
Mass (Da):
60902
Number AA:
535
UniProt ID:
O15460
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y35
G
H
M
T
D
L
I
Y
A
E
K
E
L
V
Q
Site 2
S56
L
V
E
E
A
K
L
S
K
I
K
S
W
A
N
Site 3
S60
A
K
L
S
K
I
K
S
W
A
N
K
M
E
A
Site 4
S70
N
K
M
E
A
L
T
S
K
S
A
A
D
A
E
Site 5
S72
M
E
A
L
T
S
K
S
A
A
D
A
E
G
Y
Site 6
T95
K
L
V
K
R
L
N
T
D
W
P
A
L
E
D
Site 7
T125
V
Q
R
Q
F
F
P
T
D
E
D
E
I
G
A
Site 8
T142
A
L
M
R
L
Q
D
T
Y
R
L
D
P
G
T
Site 9
Y143
L
M
R
L
Q
D
T
Y
R
L
D
P
G
T
I
Site 10
T149
T
Y
R
L
D
P
G
T
I
S
R
G
E
L
P
Site 11
S151
R
L
D
P
G
T
I
S
R
G
E
L
P
G
T
Site 12
T158
S
R
G
E
L
P
G
T
K
Y
Q
A
M
L
S
Site 13
Y160
G
E
L
P
G
T
K
Y
Q
A
M
L
S
V
D
Site 14
Y177
F
G
M
G
R
S
A
Y
N
E
G
D
Y
Y
H
Site 15
Y182
S
A
Y
N
E
G
D
Y
Y
H
T
V
L
W
M
Site 16
Y183
A
Y
N
E
G
D
Y
Y
H
T
V
L
W
M
E
Site 17
T205
A
G
E
E
A
T
T
T
K
S
Q
V
L
D
Y
Site 18
S207
E
E
A
T
T
T
K
S
Q
V
L
D
Y
L
S
Site 19
Y212
T
K
S
Q
V
L
D
Y
L
S
Y
A
V
F
Q
Site 20
T230
L
H
R
A
L
E
L
T
R
R
L
L
S
L
D
Site 21
S235
E
L
T
R
R
L
L
S
L
D
P
S
H
E
R
Site 22
S239
R
L
L
S
L
D
P
S
H
E
R
A
G
G
N
Site 23
Y249
R
A
G
G
N
L
R
Y
F
E
Q
L
L
E
E
Site 24
T261
L
E
E
E
R
E
K
T
L
T
N
Q
T
E
A
Site 25
T263
E
E
R
E
K
T
L
T
N
Q
T
E
A
E
L
Site 26
T272
Q
T
E
A
E
L
A
T
P
E
G
I
Y
E
R
Site 27
Y277
L
A
T
P
E
G
I
Y
E
R
P
V
D
Y
L
Site 28
Y283
I
Y
E
R
P
V
D
Y
L
P
E
R
D
V
Y
Site 29
Y290
Y
L
P
E
R
D
V
Y
E
S
L
C
R
G
E
Site 30
S292
P
E
R
D
V
Y
E
S
L
C
R
G
E
G
V
Site 31
T302
R
G
E
G
V
K
L
T
P
R
R
Q
K
R
L
Site 32
Y313
Q
K
R
L
F
C
R
Y
H
H
G
N
R
A
P
Site 33
Y341
D
S
P
H
I
V
R
Y
Y
D
V
M
S
D
E
Site 34
Y342
S
P
H
I
V
R
Y
Y
D
V
M
S
D
E
E
Site 35
S346
V
R
Y
Y
D
V
M
S
D
E
E
I
E
R
I
Site 36
T365
K
P
K
L
A
R
A
T
V
R
D
P
K
T
G
Site 37
T375
D
P
K
T
G
V
L
T
V
A
S
Y
R
V
S
Site 38
S378
T
G
V
L
T
V
A
S
Y
R
V
S
K
S
S
Site 39
Y379
G
V
L
T
V
A
S
Y
R
V
S
K
S
S
W
Site 40
S382
T
V
A
S
Y
R
V
S
K
S
S
W
L
E
E
Site 41
S384
A
S
Y
R
V
S
K
S
S
W
L
E
E
D
D
Site 42
S385
S
Y
R
V
S
K
S
S
W
L
E
E
D
D
D
Site 43
T406
N
R
R
M
Q
H
I
T
G
L
T
V
K
T
A
Site 44
Y421
E
L
L
Q
V
A
N
Y
G
V
G
G
Q
Y
E
Site 45
Y427
N
Y
G
V
G
G
Q
Y
E
P
H
F
D
F
S
Site 46
T441
S
R
N
D
E
R
D
T
F
K
H
L
G
T
G
Site 47
T447
D
T
F
K
H
L
G
T
G
N
R
V
A
T
F
Site 48
T453
G
T
G
N
R
V
A
T
F
L
N
Y
M
S
D
Site 49
T482
A
I
W
P
K
K
G
T
A
V
F
W
Y
N
L
Site 50
Y487
K
G
T
A
V
F
W
Y
N
L
L
R
S
G
E
Site 51
Y497
L
R
S
G
E
G
D
Y
R
T
R
H
A
A
C
Site 52
T499
S
G
E
G
D
Y
R
T
R
H
A
A
C
P
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation