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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CLOCK
Full Name:
Circadian locomoter output cycles protein kaput
Alias:
BHLHe8; Circadian locomotor output cycles kaput; Clock; EC 2.3.1.48; KAT13D; KIAA0334
Type:
Transcription factor; EC 2.3.1.48; Acetyltransferase
Mass (Da):
95304
Number AA:
846
UniProt ID:
O15516
International Prot ID:
IPI00007284
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005667
Uniprot
OncoNet
Molecular Function:
GO:0004402
GO:0004871
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0007623
GO:0009648
GO:0045944
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
V
S
C
S
K
M
S
S
I
V
D
R
D
D
S
Site 2
S19
S
I
V
D
R
D
D
S
S
I
F
D
G
L
V
Site 3
S20
I
V
D
R
D
D
S
S
I
F
D
G
L
V
E
Site 4
S38
K
D
K
A
K
R
V
S
R
N
K
S
E
K
K
Site 5
S42
K
R
V
S
R
N
K
S
E
K
K
R
R
D
Q
Site 6
S59
V
L
I
K
E
L
G
S
M
L
P
G
N
A
R
Site 7
S71
N
A
R
K
M
D
K
S
T
V
L
Q
K
S
I
Site 8
T72
A
R
K
M
D
K
S
T
V
L
Q
K
S
I
D
Site 9
S77
K
S
T
V
L
Q
K
S
I
D
F
L
R
K
H
Site 10
S91
H
K
E
I
T
A
Q
S
D
A
S
E
I
R
Q
Site 11
S106
D
W
K
P
T
F
L
S
N
E
E
F
T
Q
L
Site 12
S140
Y
V
S
E
S
V
T
S
L
L
E
H
L
P
S
Site 13
S147
S
L
L
E
H
L
P
S
D
L
V
D
Q
S
I
Site 14
S153
P
S
D
L
V
D
Q
S
I
F
N
F
I
P
E
Site 15
S164
F
I
P
E
G
E
H
S
E
V
Y
K
I
L
S
Site 16
Y167
E
G
E
H
S
E
V
Y
K
I
L
S
T
H
L
Site 17
S171
S
E
V
Y
K
I
L
S
T
H
L
L
E
S
D
Site 18
S177
L
S
T
H
L
L
E
S
D
S
L
T
P
E
Y
Site 19
S179
T
H
L
L
E
S
D
S
L
T
P
E
Y
L
K
Site 20
T181
L
L
E
S
D
S
L
T
P
E
Y
L
K
S
K
Site 21
Y184
S
D
S
L
T
P
E
Y
L
K
S
K
N
Q
L
Site 22
S187
L
T
P
E
Y
L
K
S
K
N
Q
L
E
F
C
Site 23
T201
C
C
H
M
L
R
G
T
I
D
P
K
E
P
S
Site 24
Y210
D
P
K
E
P
S
T
Y
E
Y
V
K
F
I
G
Site 25
Y212
K
E
P
S
T
Y
E
Y
V
K
F
I
G
N
F
Site 26
S221
K
F
I
G
N
F
K
S
L
N
S
V
S
S
S
Site 27
S224
G
N
F
K
S
L
N
S
V
S
S
S
A
H
N
Site 28
S226
F
K
S
L
N
S
V
S
S
S
A
H
N
G
F
Site 29
S227
K
S
L
N
S
V
S
S
S
A
H
N
G
F
E
Site 30
S228
S
L
N
S
V
S
S
S
A
H
N
G
F
E
G
Site 31
T240
F
E
G
T
I
Q
R
T
H
R
P
S
Y
E
D
Site 32
S244
I
Q
R
T
H
R
P
S
Y
E
D
R
V
C
F
Site 33
Y245
Q
R
T
H
R
P
S
Y
E
D
R
V
C
F
V
Site 34
T277
E
E
P
N
E
E
F
T
S
R
H
S
L
E
W
Site 35
S278
E
P
N
E
E
F
T
S
R
H
S
L
E
W
K
Site 36
S281
E
E
F
T
S
R
H
S
L
E
W
K
F
L
F
Site 37
T307
L
P
F
E
V
L
G
T
S
G
Y
D
Y
Y
H
Site 38
Y310
E
V
L
G
T
S
G
Y
D
Y
Y
H
V
D
D
Site 39
Y312
L
G
T
S
G
Y
D
Y
Y
H
V
D
D
L
E
Site 40
Y313
G
T
S
G
Y
D
Y
Y
H
V
D
D
L
E
N
Site 41
Y331
C
H
E
H
L
M
Q
Y
G
K
G
K
S
C
Y
Site 42
Y338
Y
G
K
G
K
S
C
Y
Y
R
F
L
T
K
G
Site 43
S394
R
E
L
G
I
E
E
S
L
P
E
T
A
A
D
Site 44
T398
I
E
E
S
L
P
E
T
A
A
D
K
S
Q
D
Site 45
S403
P
E
T
A
A
D
K
S
Q
D
S
G
S
D
N
Site 46
S406
A
A
D
K
S
Q
D
S
G
S
D
N
R
I
N
Site 47
S408
D
K
S
Q
D
S
G
S
D
N
R
I
N
T
V
Site 48
T414
G
S
D
N
R
I
N
T
V
S
L
K
E
A
L
Site 49
S416
D
N
R
I
N
T
V
S
L
K
E
A
L
E
R
Site 50
S427
A
L
E
R
F
D
H
S
P
T
P
S
A
S
S
Site 51
T429
E
R
F
D
H
S
P
T
P
S
A
S
S
R
S
Site 52
S431
F
D
H
S
P
T
P
S
A
S
S
R
S
S
R
Site 53
S433
H
S
P
T
P
S
A
S
S
R
S
S
R
K
S
Site 54
S434
S
P
T
P
S
A
S
S
R
S
S
R
K
S
S
Site 55
S436
T
P
S
A
S
S
R
S
S
R
K
S
S
H
T
Site 56
S437
P
S
A
S
S
R
S
S
R
K
S
S
H
T
A
Site 57
S440
S
S
R
S
S
R
K
S
S
H
T
A
V
S
D
Site 58
S441
S
R
S
S
R
K
S
S
H
T
A
V
S
D
P
Site 59
T443
S
S
R
K
S
S
H
T
A
V
S
D
P
S
S
Site 60
S446
K
S
S
H
T
A
V
S
D
P
S
S
T
P
T
Site 61
S449
H
T
A
V
S
D
P
S
S
T
P
T
K
I
P
Site 62
S450
T
A
V
S
D
P
S
S
T
P
T
K
I
P
T
Site 63
T451
A
V
S
D
P
S
S
T
P
T
K
I
P
T
D
Site 64
T453
S
D
P
S
S
T
P
T
K
I
P
T
D
T
S
Site 65
T457
S
T
P
T
K
I
P
T
D
T
S
T
P
P
R
Site 66
T459
P
T
K
I
P
T
D
T
S
T
P
P
R
Q
H
Site 67
S460
T
K
I
P
T
D
T
S
T
P
P
R
Q
H
L
Site 68
T461
K
I
P
T
D
T
S
T
P
P
R
Q
H
L
P
Site 69
S478
E
K
M
V
Q
R
R
S
S
F
S
S
Q
S
I
Site 70
S479
K
M
V
Q
R
R
S
S
F
S
S
Q
S
I
N
Site 71
S481
V
Q
R
R
S
S
F
S
S
Q
S
I
N
S
Q
Site 72
S482
Q
R
R
S
S
F
S
S
Q
S
I
N
S
Q
S
Site 73
S484
R
S
S
F
S
S
Q
S
I
N
S
Q
S
V
G
Site 74
S487
F
S
S
Q
S
I
N
S
Q
S
V
G
S
S
L
Site 75
S489
S
Q
S
I
N
S
Q
S
V
G
S
S
L
T
Q
Site 76
S493
N
S
Q
S
V
G
S
S
L
T
Q
P
V
M
S
Site 77
T495
Q
S
V
G
S
S
L
T
Q
P
V
M
S
Q
A
Site 78
S512
L
P
I
P
Q
G
M
S
Q
F
Q
F
S
A
Q
Site 79
S570
L
Q
M
F
L
Q
Q
S
N
P
G
L
N
F
G
Site 80
S578
N
P
G
L
N
F
G
S
V
Q
L
S
S
G
N
Site 81
S582
N
F
G
S
V
Q
L
S
S
G
N
S
S
N
I
Site 82
S583
F
G
S
V
Q
L
S
S
G
N
S
S
N
I
Q
Site 83
S586
V
Q
L
S
S
G
N
S
S
N
I
Q
Q
L
A
Site 84
S587
Q
L
S
S
G
N
S
S
N
I
Q
Q
L
A
P
Site 85
T613
Q
I
Q
S
G
M
N
T
G
H
I
G
T
T
Q
Site 86
T627
Q
H
M
I
Q
Q
Q
T
L
Q
S
T
S
T
Q
Site 87
S630
I
Q
Q
Q
T
L
Q
S
T
S
T
Q
S
Q
Q
Site 88
S635
L
Q
S
T
S
T
Q
S
Q
Q
N
V
L
S
G
Site 89
S641
Q
S
Q
Q
N
V
L
S
G
H
S
Q
Q
T
S
Site 90
S644
Q
N
V
L
S
G
H
S
Q
Q
T
S
L
P
S
Site 91
T647
L
S
G
H
S
Q
Q
T
S
L
P
S
Q
T
Q
Site 92
S648
S
G
H
S
Q
Q
T
S
L
P
S
Q
T
Q
S
Site 93
S651
S
Q
Q
T
S
L
P
S
Q
T
Q
S
T
L
T
Site 94
S655
S
L
P
S
Q
T
Q
S
T
L
T
A
P
L
Y
Site 95
S680
G
S
M
V
Q
I
P
S
S
M
P
Q
N
S
T
Site 96
S681
S
M
V
Q
I
P
S
S
M
P
Q
N
S
T
Q
Site 97
S686
P
S
S
M
P
Q
N
S
T
Q
S
A
A
V
T
Site 98
T693
S
T
Q
S
A
A
V
T
T
F
T
Q
D
R
Q
Site 99
T696
S
A
A
V
T
T
F
T
Q
D
R
Q
I
R
F
Site 100
S704
Q
D
R
Q
I
R
F
S
Q
G
Q
Q
L
V
T
Site 101
S748
F
A
T
Q
Q
Q
Q
S
Q
T
L
S
V
T
Q
Site 102
T750
T
Q
Q
Q
Q
S
Q
T
L
S
V
T
Q
Q
Q
Site 103
S752
Q
Q
Q
S
Q
T
L
S
V
T
Q
Q
Q
Q
Q
Site 104
S762
Q
Q
Q
Q
Q
Q
S
S
Q
E
Q
Q
L
T
S
Site 105
T768
S
S
Q
E
Q
Q
L
T
S
V
Q
Q
P
S
Q
Site 106
S769
S
Q
E
Q
Q
L
T
S
V
Q
Q
P
S
Q
A
Site 107
S774
L
T
S
V
Q
Q
P
S
Q
A
Q
L
T
Q
P
Site 108
T779
Q
P
S
Q
A
Q
L
T
Q
P
P
Q
Q
F
L
Site 109
T788
P
P
Q
Q
F
L
Q
T
S
R
L
L
H
G
N
Site 110
S811
A
A
F
P
L
Q
Q
S
T
F
P
Q
S
H
H
Site 111
T812
A
F
P
L
Q
Q
S
T
F
P
Q
S
H
H
Q
Site 112
S823
S
H
H
Q
Q
H
Q
S
Q
Q
Q
Q
Q
L
S
Site 113
S830
S
Q
Q
Q
Q
Q
L
S
R
H
R
T
D
S
L
Site 114
T834
Q
Q
L
S
R
H
R
T
D
S
L
P
D
P
S
Site 115
S836
L
S
R
H
R
T
D
S
L
P
D
P
S
K
V
Site 116
S841
T
D
S
L
P
D
P
S
K
V
Q
P
Q
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation