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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CYP27B1
Full Name:
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial
Alias:
25-OHD-1 alpha-hydroxylase;25-hydroxyvitamin D(3) 1-alpha-hydroxylase;Calcidiol 1-monooxygenase;Cytochrome P450 subfamily XXVIIB polypeptide 1;Cytochrome P450C1 alpha;Cytochrome P450VD1-alpha;Cytochrome p450 27B1
Type:
Mass (Da):
56504
Number AA:
508
UniProt ID:
O15528
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y7
_
M
T
Q
T
L
K
Y
A
S
R
V
F
H
R
Site 2
S24
W
A
P
E
L
G
A
S
L
G
Y
R
E
Y
H
Site 3
Y30
A
S
L
G
Y
R
E
Y
H
S
A
R
R
S
L
Site 4
S32
L
G
Y
R
E
Y
H
S
A
R
R
S
L
A
D
Site 5
S36
E
Y
H
S
A
R
R
S
L
A
D
I
P
G
P
Site 6
S109
G
P
R
P
E
R
C
S
F
S
P
W
T
E
H
Site 7
S111
R
P
E
R
C
S
F
S
P
W
T
E
H
R
R
Site 8
T177
R
R
Q
R
G
R
G
T
G
P
P
A
L
V
R
Site 9
T218
E
A
Q
V
P
P
D
T
E
T
F
I
R
A
V
Site 10
T220
Q
V
P
P
D
T
E
T
F
I
R
A
V
G
S
Site 11
S289
Q
P
E
K
D
L
E
S
G
A
H
L
T
H
F
Site 12
T325
G
V
D
T
V
S
N
T
L
S
W
A
L
Y
E
Site 13
S327
D
T
V
S
N
T
L
S
W
A
L
Y
E
L
S
Site 14
Y331
N
T
L
S
W
A
L
Y
E
L
S
R
H
P
E
Site 15
S334
S
W
A
L
Y
E
L
S
R
H
P
E
V
Q
T
Site 16
S352
S
E
I
T
A
A
L
S
P
G
S
S
A
Y
P
Site 17
S355
T
A
A
L
S
P
G
S
S
A
Y
P
S
A
T
Site 18
S360
P
G
S
S
A
Y
P
S
A
T
V
L
S
Q
L
Site 19
Y400
K
D
I
H
V
G
D
Y
I
I
P
K
N
T
L
Site 20
T415
V
T
L
C
H
Y
A
T
S
R
D
P
A
Q
F
Site 21
S427
A
Q
F
P
E
P
N
S
F
R
P
A
R
W
L
Site 22
T439
R
W
L
G
E
G
P
T
P
H
P
F
A
S
L
Site 23
S445
P
T
P
H
P
F
A
S
L
P
F
G
F
G
K
Site 24
S454
P
F
G
F
G
K
R
S
C
M
G
R
R
L
A
Site 25
T491
A
A
P
V
R
P
K
T
R
T
V
L
V
P
E
Site 26
T493
P
V
R
P
K
T
R
T
V
L
V
P
E
R
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation