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Updated November 2019
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Protein Info
Short Name:
UTX
Full Name:
Lysine-specific demethylase 6A
Alias:
Histone demethylase UTX; Lysine (K)-specific demethylase 6A; Ubiquitously transcribed TPR protein ON the X chromosome; Ubiquitously transcribed TPR protein on the X chromosome; Ubiquitously transcribed X chromosome tetratricopeptide repeat protein
Type:
Oxidoreductase; EC 1.14.11.-
Mass (Da):
154177
Number AA:
1401
UniProt ID:
O15550
International Prot ID:
IPI00007362
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0005730
Uniprot
OncoNet
Molecular Function:
GO:0005506
GO:0016702
PhosphoSite+
KinaseNET
Biological Process:
GO:0016568
GO:0055114
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S34
A
G
K
A
S
G
E
S
E
E
A
S
P
S
L
Site 2
S38
S
G
E
S
E
E
A
S
P
S
L
T
A
E
E
Site 3
S40
E
S
E
E
A
S
P
S
L
T
A
E
E
R
E
Site 4
T42
E
E
A
S
P
S
L
T
A
E
E
R
E
A
L
Site 5
S93
K
A
E
G
K
V
E
S
D
F
F
C
Q
L
G
Site 6
S114
E
D
Y
P
K
A
L
S
A
Y
Q
R
Y
Y
S
Site 7
Y116
Y
P
K
A
L
S
A
Y
Q
R
Y
Y
S
L
Q
Site 8
Y119
A
L
S
A
Y
Q
R
Y
Y
S
L
Q
S
D
Y
Site 9
Y120
L
S
A
Y
Q
R
Y
Y
S
L
Q
S
D
Y
W
Site 10
S121
S
A
Y
Q
R
Y
Y
S
L
Q
S
D
Y
W
K
Site 11
Y126
Y
Y
S
L
Q
S
D
Y
W
K
N
A
A
F
L
Site 12
Y158
K
A
F
Q
E
V
L
Y
V
D
P
S
F
C
R
Site 13
S162
E
V
L
Y
V
D
P
S
F
C
R
A
K
E
I
Site 14
T181
G
L
M
F
K
V
N
T
D
Y
E
S
S
L
K
Site 15
Y183
M
F
K
V
N
T
D
Y
E
S
S
L
K
H
F
Site 16
Y215
Q
F
H
I
A
H
L
Y
E
T
Q
R
K
Y
H
Site 17
T217
H
I
A
H
L
Y
E
T
Q
R
K
Y
H
S
A
Site 18
Y221
L
Y
E
T
Q
R
K
Y
H
S
A
K
E
A
Y
Site 19
T255
Q
L
G
W
M
H
H
T
V
D
L
L
G
D
K
Site 20
Y272
K
E
S
Y
A
I
Q
Y
L
Q
K
S
L
E
A
Site 21
S276
A
I
Q
Y
L
Q
K
S
L
E
A
D
P
N
S
Site 22
S283
S
L
E
A
D
P
N
S
G
Q
S
W
Y
F
L
Site 23
Y288
P
N
S
G
Q
S
W
Y
F
L
G
R
C
Y
S
Site 24
Y294
W
Y
F
L
G
R
C
Y
S
S
I
G
K
V
Q
Site 25
S295
Y
F
L
G
R
C
Y
S
S
I
G
K
V
Q
D
Site 26
S306
K
V
Q
D
A
F
I
S
Y
R
Q
S
I
D
K
Site 27
S310
A
F
I
S
Y
R
Q
S
I
D
K
S
E
A
S
Site 28
S314
Y
R
Q
S
I
D
K
S
E
A
S
A
D
T
W
Site 29
S317
S
I
D
K
S
E
A
S
A
D
T
W
C
S
I
Site 30
Y362
W
M
D
L
G
T
L
Y
E
S
C
N
Q
P
Q
Site 31
Y375
P
Q
D
A
I
K
C
Y
L
N
A
T
R
S
K
Site 32
T379
I
K
C
Y
L
N
A
T
R
S
K
S
C
S
N
Site 33
S381
C
Y
L
N
A
T
R
S
K
S
C
S
N
T
S
Site 34
S383
L
N
A
T
R
S
K
S
C
S
N
T
S
A
L
Site 35
S385
A
T
R
S
K
S
C
S
N
T
S
A
L
A
A
Site 36
T387
R
S
K
S
C
S
N
T
S
A
L
A
A
R
I
Site 37
S388
S
K
S
C
S
N
T
S
A
L
A
A
R
I
K
Site 38
S418
N
K
T
K
L
L
P
S
I
E
E
A
W
S
L
Site 39
S450
Q
N
T
S
D
N
W
S
G
G
H
A
V
S
H
Site 40
S456
W
S
G
G
H
A
V
S
H
P
P
V
Q
Q
Q
Site 41
T470
Q
A
H
S
W
C
L
T
P
Q
K
L
Q
H
L
Site 42
T513
Q
Q
H
Q
M
R
P
T
G
V
A
Q
V
R
S
Site 43
S520
T
G
V
A
Q
V
R
S
T
G
I
P
N
G
P
Site 44
T521
G
V
A
Q
V
R
S
T
G
I
P
N
G
P
T
Site 45
T528
T
G
I
P
N
G
P
T
A
D
S
S
L
P
T
Site 46
S531
P
N
G
P
T
A
D
S
S
L
P
T
N
S
V
Site 47
S532
N
G
P
T
A
D
S
S
L
P
T
N
S
V
S
Site 48
T535
T
A
D
S
S
L
P
T
N
S
V
S
G
Q
Q
Site 49
S537
D
S
S
L
P
T
N
S
V
S
G
Q
Q
P
Q
Site 50
T548
Q
Q
P
Q
L
A
L
T
R
V
P
S
V
S
Q
Site 51
S552
L
A
L
T
R
V
P
S
V
S
Q
P
G
V
R
Site 52
S554
L
T
R
V
P
S
V
S
Q
P
G
V
R
P
A
Site 53
S580
S
A
G
H
V
P
C
S
T
S
R
T
L
G
S
Site 54
T581
A
G
H
V
P
C
S
T
S
R
T
L
G
S
T
Site 55
S582
G
H
V
P
C
S
T
S
R
T
L
G
S
T
D
Site 56
T584
V
P
C
S
T
S
R
T
L
G
S
T
D
T
I
Site 57
S587
S
T
S
R
T
L
G
S
T
D
T
I
L
I
G
Site 58
T588
T
S
R
T
L
G
S
T
D
T
I
L
I
G
N
Site 59
T590
R
T
L
G
S
T
D
T
I
L
I
G
N
N
H
Site 60
T599
L
I
G
N
N
H
I
T
G
S
G
S
N
G
N
Site 61
S601
G
N
N
H
I
T
G
S
G
S
N
G
N
V
P
Site 62
T622
L
T
L
P
H
N
R
T
N
L
T
S
S
A
E
Site 63
S626
H
N
R
T
N
L
T
S
S
A
E
E
P
W
K
Site 64
S637
E
P
W
K
N
Q
L
S
N
S
T
Q
G
L
H
Site 65
S639
W
K
N
Q
L
S
N
S
T
Q
G
L
H
K
G
Site 66
S648
Q
G
L
H
K
G
Q
S
S
H
S
A
G
P
N
Site 67
S649
G
L
H
K
G
Q
S
S
H
S
A
G
P
N
G
Site 68
S651
H
K
G
Q
S
S
H
S
A
G
P
N
G
E
R
Site 69
S661
P
N
G
E
R
P
L
S
S
T
G
P
S
Q
H
Site 70
S662
N
G
E
R
P
L
S
S
T
G
P
S
Q
H
L
Site 71
T663
G
E
R
P
L
S
S
T
G
P
S
Q
H
L
Q
Site 72
S666
P
L
S
S
T
G
P
S
Q
H
L
Q
A
A
G
Site 73
S674
Q
H
L
Q
A
A
G
S
G
I
Q
N
Q
N
G
Site 74
T684
Q
N
Q
N
G
H
P
T
L
P
S
N
S
V
T
Site 75
S687
N
G
H
P
T
L
P
S
N
S
V
T
Q
G
A
Site 76
S689
H
P
T
L
P
S
N
S
V
T
Q
G
A
A
L
Site 77
T691
T
L
P
S
N
S
V
T
Q
G
A
A
L
N
H
Site 78
S700
G
A
A
L
N
H
L
S
S
H
T
A
T
S
G
Site 79
S701
A
A
L
N
H
L
S
S
H
T
A
T
S
G
G
Site 80
T713
S
G
G
Q
Q
G
I
T
L
T
K
E
S
K
P
Site 81
T715
G
Q
Q
G
I
T
L
T
K
E
S
K
P
S
G
Site 82
S721
L
T
K
E
S
K
P
S
G
N
I
L
T
V
P
Site 83
T726
K
P
S
G
N
I
L
T
V
P
E
T
S
R
H
Site 84
T730
N
I
L
T
V
P
E
T
S
R
H
T
G
E
T
Site 85
T734
V
P
E
T
S
R
H
T
G
E
T
P
N
S
T
Site 86
T737
T
S
R
H
T
G
E
T
P
N
S
T
A
S
V
Site 87
S740
H
T
G
E
T
P
N
S
T
A
S
V
E
G
L
Site 88
T741
T
G
E
T
P
N
S
T
A
S
V
E
G
L
P
Site 89
S743
E
T
P
N
S
T
A
S
V
E
G
L
P
N
H
Site 90
S761
M
T
A
D
A
V
C
S
P
S
H
G
D
S
K
Site 91
S763
A
D
A
V
C
S
P
S
H
G
D
S
K
S
P
Site 92
S767
C
S
P
S
H
G
D
S
K
S
P
G
L
L
S
Site 93
S769
P
S
H
G
D
S
K
S
P
G
L
L
S
S
D
Site 94
S774
S
K
S
P
G
L
L
S
S
D
N
P
Q
L
S
Site 95
S775
K
S
P
G
L
L
S
S
D
N
P
Q
L
S
A
Site 96
S781
S
S
D
N
P
Q
L
S
A
L
L
M
G
K
A
Site 97
T811
H
P
A
V
H
T
K
T
D
N
S
V
A
S
S
Site 98
S814
V
H
T
K
T
D
N
S
V
A
S
S
P
S
S
Site 99
S817
K
T
D
N
S
V
A
S
S
P
S
S
A
I
S
Site 100
S818
T
D
N
S
V
A
S
S
P
S
S
A
I
S
T
Site 101
S820
N
S
V
A
S
S
P
S
S
A
I
S
T
A
T
Site 102
S821
S
V
A
S
S
P
S
S
A
I
S
T
A
T
P
Site 103
S824
S
S
P
S
S
A
I
S
T
A
T
P
S
P
K
Site 104
T825
S
P
S
S
A
I
S
T
A
T
P
S
P
K
S
Site 105
T827
S
S
A
I
S
T
A
T
P
S
P
K
S
T
E
Site 106
S829
A
I
S
T
A
T
P
S
P
K
S
T
E
Q
T
Site 107
S832
T
A
T
P
S
P
K
S
T
E
Q
T
T
T
N
Site 108
T833
A
T
P
S
P
K
S
T
E
Q
T
T
T
N
S
Site 109
T836
S
P
K
S
T
E
Q
T
T
T
N
S
V
T
S
Site 110
T838
K
S
T
E
Q
T
T
T
N
S
V
T
S
L
N
Site 111
S840
T
E
Q
T
T
T
N
S
V
T
S
L
N
S
P
Site 112
T842
Q
T
T
T
N
S
V
T
S
L
N
S
P
H
S
Site 113
S843
T
T
T
N
S
V
T
S
L
N
S
P
H
S
G
Site 114
S846
N
S
V
T
S
L
N
S
P
H
S
G
L
H
T
Site 115
S849
T
S
L
N
S
P
H
S
G
L
H
T
I
N
G
Site 116
T853
S
P
H
S
G
L
H
T
I
N
G
E
G
M
E
Site 117
S862
N
G
E
G
M
E
E
S
Q
S
P
M
K
T
D
Site 118
S864
E
G
M
E
E
S
Q
S
P
M
K
T
D
L
L
Site 119
T868
E
S
Q
S
P
M
K
T
D
L
L
L
V
N
H
Site 120
S909
N
L
G
K
N
G
L
S
N
S
S
I
L
L
D
Site 121
S911
G
K
N
G
L
S
N
S
S
I
L
L
D
K
C
Site 122
S925
C
P
P
P
R
P
P
S
S
P
Y
P
P
L
P
Site 123
S926
P
P
P
R
P
P
S
S
P
Y
P
P
L
P
K
Site 124
Y928
P
R
P
P
S
S
P
Y
P
P
L
P
K
D
K
Site 125
T940
K
D
K
L
N
P
P
T
P
S
I
Y
L
E
N
Site 126
Y944
N
P
P
T
P
S
I
Y
L
E
N
K
R
D
A
Site 127
T968
T
N
P
N
N
P
V
T
V
I
R
G
L
A
G
Site 128
T988
L
G
L
F
S
T
K
T
L
V
E
A
N
N
E
Site 129
T1030
C
E
S
N
R
S
H
T
T
I
A
K
Y
A
Q
Site 130
Y1035
S
H
T
T
I
A
K
Y
A
Q
Y
Q
A
S
S
Site 131
Y1038
T
I
A
K
Y
A
Q
Y
Q
A
S
S
F
Q
E
Site 132
S1041
K
Y
A
Q
Y
Q
A
S
S
F
Q
E
S
L
R
Site 133
S1042
Y
A
Q
Y
Q
A
S
S
F
Q
E
S
L
R
E
Site 134
S1046
Q
A
S
S
F
Q
E
S
L
R
E
E
N
E
K
Site 135
S1061
R
S
H
H
K
D
H
S
D
S
E
S
T
S
S
Site 136
S1063
H
H
K
D
H
S
D
S
E
S
T
S
S
D
N
Site 137
S1065
K
D
H
S
D
S
E
S
T
S
S
D
N
S
G
Site 138
S1067
H
S
D
S
E
S
T
S
S
D
N
S
G
R
R
Site 139
S1068
S
D
S
E
S
T
S
S
D
N
S
G
R
R
R
Site 140
S1071
E
S
T
S
S
D
N
S
G
R
R
R
K
G
P
Site 141
T1081
R
R
K
G
P
F
K
T
I
K
F
G
T
N
I
Site 142
S1091
F
G
T
N
I
D
L
S
D
D
K
K
W
K
L
Site 143
Y1135
G
M
N
T
V
Q
L
Y
M
K
V
P
G
S
R
Site 144
S1141
L
Y
M
K
V
P
G
S
R
T
P
G
H
Q
E
Site 145
T1143
M
K
V
P
G
S
R
T
P
G
H
Q
E
N
N
Site 146
Y1201
W
P
N
L
E
D
L
Y
E
A
N
V
P
V
Y
Site 147
Y1256
Y
K
L
A
V
E
R
Y
E
W
N
K
L
Q
S
Site 148
S1284
M
A
R
N
I
K
V
S
D
P
K
L
F
E
M
Site 149
T1305
R
T
L
K
Q
C
Q
T
L
R
E
A
L
I
A
Site 150
Y1330
T
K
E
E
P
A
H
Y
C
S
I
C
E
V
E
Site 151
T1345
V
F
D
L
L
F
V
T
N
E
S
N
S
R
K
Site 152
S1348
L
L
F
V
T
N
E
S
N
S
R
K
T
Y
I
Site 153
Y1354
E
S
N
S
R
K
T
Y
I
V
H
C
Q
D
C
Site 154
S1366
Q
D
C
A
R
K
T
S
G
N
L
E
N
F
V
Site 155
Y1387
M
E
D
L
M
Q
V
Y
D
Q
F
T
L
A
P
Site 156
T1391
M
Q
V
Y
D
Q
F
T
L
A
P
P
L
P
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation