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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DHX15
Full Name:
Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15
Alias:
ATP-dependent RNA helicase #46; DBP1; DBP1;DHX15; DEA/H (Asp-Glu-Ala-His) box polypeptide 15; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 15; DEAD/H box-15; DEAH (Asp-Glu-Ala-His) box polypeptide 15; DEAH box protein 15; EC 3.6.1.-; HRH2; PRP43; PRPF43; PrPp43p; RNA helicase 2
Type:
DNA binding protein, helicase
Mass (Da):
90933
Number AA:
795
UniProt ID:
O43143
International Prot ID:
IPI00396435
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005689
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0008026
GO:0003724
PhosphoSite+
KinaseNET
Biological Process:
GO:0008380
GO:0006397
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y13
R
L
D
L
G
E
D
Y
P
S
G
K
K
R
A
Site 2
S15
D
L
G
E
D
Y
P
S
G
K
K
R
A
G
T
Site 3
T22
S
G
K
K
R
A
G
T
D
G
K
D
R
D
R
Site 4
S37
D
R
D
R
E
D
R
S
K
D
R
D
R
E
R
Site 5
S64
K
E
K
E
L
R
A
S
T
N
A
M
L
I
S
Site 6
T65
E
K
E
L
R
A
S
T
N
A
M
L
I
S
A
Site 7
S80
G
L
P
P
L
K
A
S
H
S
A
H
S
T
H
Site 8
S82
P
P
L
K
A
S
H
S
A
H
S
T
H
S
A
Site 9
S85
K
A
S
H
S
A
H
S
T
H
S
A
H
S
T
Site 10
T86
A
S
H
S
A
H
S
T
H
S
A
H
S
T
H
Site 11
S88
H
S
A
H
S
T
H
S
A
H
S
T
H
S
T
Site 12
S91
H
S
T
H
S
A
H
S
T
H
S
T
H
S
A
Site 13
T92
S
T
H
S
A
H
S
T
H
S
T
H
S
A
H
Site 14
S94
H
S
A
H
S
T
H
S
T
H
S
A
H
S
T
Site 15
T95
S
A
H
S
T
H
S
T
H
S
A
H
S
T
H
Site 16
S97
H
S
T
H
S
T
H
S
A
H
S
T
H
A
G
Site 17
T101
S
T
H
S
A
H
S
T
H
A
G
H
A
G
H
Site 18
S110
A
G
H
A
G
H
T
S
L
P
Q
C
I
N
P
Site 19
T119
P
Q
C
I
N
P
F
T
N
L
P
H
T
P
R
Site 20
T124
P
F
T
N
L
P
H
T
P
R
Y
Y
D
I
L
Site 21
Y127
N
L
P
H
T
P
R
Y
Y
D
I
L
K
K
R
Site 22
Y128
L
P
H
T
P
R
Y
Y
D
I
L
K
K
R
L
Site 23
Y142
L
Q
L
P
V
W
E
Y
K
D
R
F
T
D
I
Site 24
S155
D
I
L
V
R
H
Q
S
F
V
L
V
G
E
T
Site 25
T162
S
F
V
L
V
G
E
T
G
S
G
K
T
T
Q
Site 26
S164
V
L
V
G
E
T
G
S
G
K
T
T
Q
I
P
Site 27
T168
E
T
G
S
G
K
T
T
Q
I
P
Q
W
C
V
Site 28
Y177
I
P
Q
W
C
V
E
Y
M
R
S
L
P
G
P
Site 29
S180
W
C
V
E
Y
M
R
S
L
P
G
P
K
R
G
Site 30
T191
P
K
R
G
V
A
C
T
Q
P
R
R
V
A
A
Site 31
S200
P
R
R
V
A
A
M
S
V
A
Q
R
V
A
D
Site 32
S220
L
G
Q
E
V
G
Y
S
I
R
F
E
D
C
S
Site 33
S227
S
I
R
F
E
D
C
S
S
A
K
T
I
L
K
Site 34
S228
I
R
F
E
D
C
S
S
A
K
T
I
L
K
Y
Site 35
T231
E
D
C
S
S
A
K
T
I
L
K
Y
M
T
D
Site 36
Y254
N
D
P
L
L
E
R
Y
G
V
I
I
L
D
E
Site 37
S284
K
E
V
V
R
Q
R
S
D
L
K
V
I
V
M
Site 38
S292
D
L
K
V
I
V
M
S
A
T
L
D
A
G
K
Site 39
T311
F
D
N
C
P
L
L
T
I
P
G
R
T
H
P
Site 40
T324
H
P
V
E
I
F
Y
T
P
E
P
E
R
D
Y
Site 41
Y331
T
P
E
P
E
R
D
Y
L
E
A
A
I
R
T
Site 42
Y389
D
I
K
I
I
P
L
Y
S
T
L
P
P
Q
Q
Site 43
S390
I
K
I
I
P
L
Y
S
T
L
P
P
Q
Q
Q
Site 44
T459
R
V
E
S
L
L
V
T
A
I
S
K
A
S
A
Site 45
Y485
P
G
K
C
F
R
L
Y
T
E
K
A
Y
K
T
Site 46
T486
G
K
C
F
R
L
Y
T
E
K
A
Y
K
T
E
Site 47
Y490
R
L
Y
T
E
K
A
Y
K
T
E
M
Q
D
N
Site 48
T498
K
T
E
M
Q
D
N
T
Y
P
E
I
L
R
S
Site 49
Y499
T
E
M
Q
D
N
T
Y
P
E
I
L
R
S
N
Site 50
T535
M
D
P
P
A
P
E
T
L
M
R
A
L
E
L
Site 51
T556
L
N
D
D
G
D
L
T
E
L
G
S
M
M
A
Site 52
T604
P
Q
C
F
V
R
P
T
E
A
K
K
A
A
D
Site 53
T626
H
I
D
G
D
H
L
T
L
L
N
V
Y
H
A
Site 54
Y645
H
E
S
V
Q
W
C
Y
D
N
F
I
N
Y
R
Site 55
Y651
C
Y
D
N
F
I
N
Y
R
S
L
M
S
A
D
Site 56
S677
R
F
N
L
P
R
R
S
T
D
F
T
S
R
D
Site 57
T678
F
N
L
P
R
R
S
T
D
F
T
S
R
D
Y
Site 58
T681
P
R
R
S
T
D
F
T
S
R
D
Y
Y
I
N
Site 59
S682
R
R
S
T
D
F
T
S
R
D
Y
Y
I
N
I
Site 60
Y685
T
D
F
T
S
R
D
Y
Y
I
N
I
R
K
A
Site 61
Y686
D
F
T
S
R
D
Y
Y
I
N
I
R
K
A
L
Site 62
T695
N
I
R
K
A
L
V
T
G
Y
F
M
Q
V
A
Site 63
Y697
R
K
A
L
V
T
G
Y
F
M
Q
V
A
H
L
Site 64
Y710
H
L
E
R
T
G
H
Y
L
T
V
K
D
N
Q
Site 65
T712
E
R
T
G
H
Y
L
T
V
K
D
N
Q
V
V
Site 66
T725
V
V
Q
L
H
P
S
T
V
L
D
H
K
P
E
Site 67
Y736
H
K
P
E
W
V
L
Y
N
E
F
V
L
T
T
Site 68
T742
L
Y
N
E
F
V
L
T
T
K
N
Y
I
R
T
Site 69
T751
K
N
Y
I
R
T
C
T
D
I
K
P
E
W
L
Site 70
Y765
L
V
K
I
A
P
Q
Y
Y
D
M
S
N
F
P
Site 71
Y766
V
K
I
A
P
Q
Y
Y
D
M
S
N
F
P
Q
Site 72
S789
R
I
I
A
K
L
Q
S
K
E
Y
S
Q
Y
_
Site 73
Y792
A
K
L
Q
S
K
E
Y
S
Q
Y
_
_
_
_
Site 74
S793
K
L
Q
S
K
E
Y
S
Q
Y
_
_
_
_
_
Site 75
Y795
Q
S
K
E
Y
S
Q
Y
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation