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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RNMT
Full Name:
mRNA cap guanine-N7 methyltransferase
Alias:
Guanine-7-; HCMT1c; MCES; Methyltransferase; MRNA; MRNA (guanine-N(7)-)-methyltransferase; MRNA cap methyltransferase; RG7MT1; RNA (guanine-7-) methyltransferase
Type:
RNA processing; EC 2.1.1.56; Methyltransferase
Mass (Da):
54844
Number AA:
476
UniProt ID:
O43148
International Prot ID:
IPI00747403
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0003723
GO:0004482
PhosphoSite+
KinaseNET
Biological Process:
GO:0006370
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y10
N
S
A
K
A
E
E
Y
E
K
M
S
L
E
Q
Site 2
S21
S
L
E
Q
A
K
A
S
V
N
S
E
T
E
S
Site 3
S24
Q
A
K
A
S
V
N
S
E
T
E
S
S
F
N
Site 4
T26
K
A
S
V
N
S
E
T
E
S
S
F
N
I
N
Site 5
S28
S
V
N
S
E
T
E
S
S
F
N
I
N
E
N
Site 6
S29
V
N
S
E
T
E
S
S
F
N
I
N
E
N
T
Site 7
S39
I
N
E
N
T
T
A
S
G
T
G
L
S
E
K
Site 8
S44
T
A
S
G
T
G
L
S
E
K
T
S
V
C
R
Site 9
T47
G
T
G
L
S
E
K
T
S
V
C
R
Q
V
D
Site 10
S48
T
G
L
S
E
K
T
S
V
C
R
Q
V
D
I
Site 11
S71
D
D
L
V
K
E
S
S
S
C
G
K
D
T
P
Site 12
T77
S
S
S
C
G
K
D
T
P
S
K
K
R
K
L
Site 13
S79
S
C
G
K
D
T
P
S
K
K
R
K
L
D
P
Site 14
S102
C
G
D
A
E
G
N
S
K
K
R
K
R
E
T
Site 15
T109
S
K
K
R
K
R
E
T
E
D
V
P
K
D
K
Site 16
S117
E
D
V
P
K
D
K
S
S
T
G
D
G
T
Q
Site 17
S118
D
V
P
K
D
K
S
S
T
G
D
G
T
Q
N
Site 18
T123
K
S
S
T
G
D
G
T
Q
N
K
R
K
I
A
Site 19
S146
K
N
L
E
E
G
H
S
S
T
V
A
A
H
Y
Site 20
S147
N
L
E
E
G
H
S
S
T
V
A
A
H
Y
N
Site 21
S165
E
V
G
L
E
K
R
S
Q
S
R
I
F
Y
L
Site 22
S167
G
L
E
K
R
S
Q
S
R
I
F
Y
L
R
N
Site 23
Y171
R
S
Q
S
R
I
F
Y
L
R
N
F
N
N
W
Site 24
T200
Q
K
K
K
R
D
I
T
V
L
D
L
G
C
G
Site 25
S249
D
M
K
N
R
R
D
S
E
Y
I
F
S
A
E
Site 26
Y251
K
N
R
R
D
S
E
Y
I
F
S
A
E
F
I
Site 27
S254
R
D
S
E
Y
I
F
S
A
E
F
I
T
A
D
Site 28
S263
E
F
I
T
A
D
S
S
K
E
L
L
I
D
K
Site 29
Y289
S
C
Q
F
V
C
H
Y
S
F
E
S
Y
E
Q
Site 30
Y294
C
H
Y
S
F
E
S
Y
E
Q
A
D
M
M
L
Site 31
S309
R
N
A
C
E
R
L
S
P
G
G
Y
F
I
G
Site 32
Y313
E
R
L
S
P
G
G
Y
F
I
G
T
T
P
N
Site 33
T317
P
G
G
Y
F
I
G
T
T
P
N
S
F
E
L
Site 34
S331
L
I
R
R
L
E
A
S
E
T
E
S
F
G
N
Site 35
T333
R
R
L
E
A
S
E
T
E
S
F
G
N
E
I
Site 36
S335
L
E
A
S
E
T
E
S
F
G
N
E
I
Y
T
Site 37
Y341
E
S
F
G
N
E
I
Y
T
V
K
F
Q
K
K
Site 38
T342
S
F
G
N
E
I
Y
T
V
K
F
Q
K
K
G
Site 39
Y351
K
F
Q
K
K
G
D
Y
P
L
F
G
C
K
Y
Site 40
Y358
Y
P
L
F
G
C
K
Y
D
F
N
L
E
G
V
Site 41
Y385
L
N
E
M
A
K
K
Y
N
M
K
L
V
Y
K
Site 42
Y391
K
Y
N
M
K
L
V
Y
K
K
T
F
L
E
F
Site 43
T394
M
K
L
V
Y
K
K
T
F
L
E
F
Y
E
E
Site 44
Y399
K
K
T
F
L
E
F
Y
E
E
K
I
K
N
N
Site 45
Y421
R
M
Q
A
L
E
P
Y
P
A
N
E
S
S
K
Site 46
S427
P
Y
P
A
N
E
S
S
K
L
V
S
E
K
V
Site 47
S431
N
E
S
S
K
L
V
S
E
K
V
D
D
Y
E
Site 48
Y437
V
S
E
K
V
D
D
Y
E
H
A
A
K
Y
M
Site 49
Y443
D
Y
E
H
A
A
K
Y
M
K
N
S
Q
V
R
Site 50
S447
A
A
K
Y
M
K
N
S
Q
V
R
L
P
L
G
Site 51
T455
Q
V
R
L
P
L
G
T
L
S
K
S
E
W
E
Site 52
S457
R
L
P
L
G
T
L
S
K
S
E
W
E
A
T
Site 53
S459
P
L
G
T
L
S
K
S
E
W
E
A
T
S
I
Site 54
T464
S
K
S
E
W
E
A
T
S
I
Y
L
V
F
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation