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Updated November 2019
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Protein Info
Short Name:
ZZEF1
Full Name:
Zinc finger ZZ-type and EF-hand domain-containing protein 1
Alias:
FLJ10821; KIAA0399; Zinc finger, ZZ type with EF hand domain 1; Zinc finger, ZZ-type with EF-hand domain 1; ZZZ4
Type:
Cell cycle regulation
Mass (Da):
331075
Number AA:
2961
UniProt ID:
O43149
International Prot ID:
IPI00385631
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005680
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0030071
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
G
N
A
P
S
H
S
S
E
D
E
A
Site 2
S8
M
G
N
A
P
S
H
S
S
E
D
E
A
A
A
Site 3
S71
L
P
T
P
P
C
E
S
L
V
S
R
H
R
G
Site 4
S74
P
P
C
E
S
L
V
S
R
H
R
G
A
L
F
Site 5
S94
R
L
G
R
G
E
E
S
V
T
L
E
Q
F
R
Site 6
T96
G
R
G
E
E
S
V
T
L
E
Q
F
R
E
L
Site 7
S112
E
A
R
G
A
G
C
S
S
E
Q
F
E
E
A
Site 8
T130
F
D
A
E
G
D
G
T
V
D
A
E
N
M
L
Site 9
S153
A
N
L
Q
G
E
L
S
H
I
I
R
Q
L
Q
Site 10
S173
P
G
F
T
D
I
F
S
E
S
K
E
G
L
D
Site 11
S196
F
L
H
R
N
R
L
S
S
A
V
M
P
Y
P
Site 12
S197
L
H
R
N
R
L
S
S
A
V
M
P
Y
P
M
Site 13
S217
N
M
C
T
M
R
S
S
V
L
K
E
S
L
D
Site 14
S222
R
S
S
V
L
K
E
S
L
D
Q
L
V
Q
K
Site 15
S233
L
V
Q
K
E
K
E
S
P
G
D
L
T
R
S
Site 16
T238
K
E
S
P
G
D
L
T
R
S
P
E
M
D
K
Site 17
S240
S
P
G
D
L
T
R
S
P
E
M
D
K
L
K
Site 18
S248
P
E
M
D
K
L
K
S
V
A
K
C
Y
A
Y
Site 19
Y255
S
V
A
K
C
Y
A
Y
I
E
T
S
S
N
S
Site 20
T269
S
A
D
I
D
K
M
T
N
G
E
T
S
S
Y
Site 21
S274
K
M
T
N
G
E
T
S
S
Y
W
Q
S
D
G
Site 22
S275
M
T
N
G
E
T
S
S
Y
W
Q
S
D
G
S
Site 23
Y276
T
N
G
E
T
S
S
Y
W
Q
S
D
G
S
A
Site 24
S279
E
T
S
S
Y
W
Q
S
D
G
S
A
C
S
H
Site 25
S311
A
V
A
A
T
D
Q
S
Y
M
P
Q
Q
V
T
Site 26
Y312
V
A
A
T
D
Q
S
Y
M
P
Q
Q
V
T
V
Site 27
T318
S
Y
M
P
Q
Q
V
T
V
A
V
G
R
N
A
Site 28
S326
V
A
V
G
R
N
A
S
D
L
Q
E
V
R
D
Site 29
Y356
N
A
N
V
S
Q
L
Y
V
Q
I
N
I
K
R
Site 30
S366
I
N
I
K
R
C
L
S
D
G
C
D
T
R
I
Site 31
S387
G
F
Q
R
V
K
K
S
G
V
S
V
S
D
A
Site 32
S390
R
V
K
K
S
G
V
S
V
S
D
A
S
A
I
Site 33
S392
K
K
S
G
V
S
V
S
D
A
S
A
I
W
Y
Site 34
S436
L
R
H
M
P
P
L
S
L
S
P
G
S
T
D
Site 35
S438
H
M
P
P
L
S
L
S
P
G
S
T
D
F
S
Site 36
S445
S
P
G
S
T
D
F
S
T
F
L
S
P
N
V
Site 37
T502
T
I
T
D
H
L
D
T
Q
Y
D
A
S
S
L
Site 38
Y504
T
D
H
L
D
T
Q
Y
D
A
S
S
L
I
L
Site 39
S508
D
T
Q
Y
D
A
S
S
L
I
L
S
M
A
S
Site 40
S512
D
A
S
S
L
I
L
S
M
A
S
V
R
Q
N
Site 41
Y524
R
Q
N
L
L
L
K
Y
G
K
P
L
Q
L
T
Site 42
T531
Y
G
K
P
L
Q
L
T
L
Q
A
C
D
V
K
Site 43
S544
V
K
G
K
E
D
K
S
G
P
E
N
L
L
V
Site 44
T555
N
L
L
V
E
P
W
T
R
D
G
F
L
T
E
Site 45
T561
W
T
R
D
G
F
L
T
E
T
G
K
T
R
A
Site 46
T566
F
L
T
E
T
G
K
T
R
A
S
T
I
F
S
Site 47
S569
E
T
G
K
T
R
A
S
T
I
F
S
T
G
T
Site 48
T570
T
G
K
T
R
A
S
T
I
F
S
T
G
T
E
Site 49
S573
T
R
A
S
T
I
F
S
T
G
T
E
S
A
F
Site 50
Y604
Q
C
G
L
V
F
A
Y
N
S
S
S
D
K
F
Site 51
S608
V
F
A
Y
N
S
S
S
D
K
F
C
A
E
E
Site 52
Y623
H
F
K
R
F
E
K
Y
D
K
W
K
L
Q
E
Site 53
S637
E
L
R
Q
F
V
K
S
R
I
G
C
S
S
D
Site 54
S642
V
K
S
R
I
G
C
S
S
D
D
L
G
E
D
Site 55
S643
K
S
R
I
G
C
S
S
D
D
L
G
E
D
D
Site 56
S688
F
L
C
T
R
Q
E
S
A
E
R
L
G
V
Q
Site 57
S700
G
V
Q
G
L
T
I
S
G
Y
L
R
P
A
R
Site 58
Y702
Q
G
L
T
I
S
G
Y
L
R
P
A
R
A
E
Site 59
S713
A
R
A
E
A
E
Q
S
V
T
C
A
H
C
R
Site 60
T715
A
E
A
E
Q
S
V
T
C
A
H
C
R
K
D
Site 61
T723
C
A
H
C
R
K
D
T
E
E
S
V
C
G
A
Site 62
S726
C
R
K
D
T
E
E
S
V
C
G
A
T
L
L
Site 63
Y757
Q
K
E
S
G
L
K
Y
K
S
F
L
D
F
A
Site 64
S759
E
S
G
L
K
Y
K
S
F
L
D
F
A
G
L
Site 65
S788
N
P
R
E
E
C
V
S
A
Q
T
L
L
L
Q
Site 66
S812
Q
G
D
V
L
A
A
S
E
E
E
K
A
P
I
Site 67
S821
E
E
K
A
P
I
Q
S
P
K
G
V
E
A
A
Site 68
S846
V
D
K
V
D
G
D
S
V
P
M
E
I
L
K
Site 69
T859
L
K
Q
E
V
R
N
T
L
L
N
G
A
A
I
Site 70
T880
T
R
R
N
H
L
F
T
M
M
N
V
T
E
Q
Site 71
S892
T
E
Q
E
H
K
Q
S
L
Q
L
T
F
R
S
Site 72
T896
H
K
Q
S
L
Q
L
T
F
R
S
L
C
T
Y
Site 73
S899
S
L
Q
L
T
F
R
S
L
C
T
Y
F
S
D
Site 74
Y903
T
F
R
S
L
C
T
Y
F
S
D
K
D
P
G
Site 75
S905
R
S
L
C
T
Y
F
S
D
K
D
P
G
G
L
Site 76
Y976
G
S
L
L
S
W
C
Y
L
Q
L
K
S
T
D
Site 77
S981
W
C
Y
L
Q
L
K
S
T
D
S
G
A
K
D
Site 78
S984
L
Q
L
K
S
T
D
S
G
A
K
D
L
A
V
Site 79
S1011
S
M
R
A
I
L
E
S
L
F
S
Q
Y
S
G
Site 80
S1017
E
S
L
F
S
Q
Y
S
G
K
T
I
V
E
R
Site 81
S1070
E
L
L
K
K
L
C
S
G
P
E
G
G
L
R
Site 82
T1094
E
Q
P
V
V
L
H
T
W
T
K
E
S
A
H
Site 83
Y1103
T
K
E
S
A
H
N
Y
E
N
N
C
H
E
V
Site 84
S1111
E
N
N
C
H
E
V
S
V
F
V
S
P
G
A
Site 85
Y1120
F
V
S
P
G
A
T
Y
F
E
V
E
F
D
D
Site 86
T1131
E
F
D
D
R
C
E
T
E
K
R
Y
D
Y
L
Site 87
Y1135
R
C
E
T
E
K
R
Y
D
Y
L
E
F
T
D
Site 88
Y1137
E
T
E
K
R
Y
D
Y
L
E
F
T
D
A
R
Site 89
T1141
R
Y
D
Y
L
E
F
T
D
A
R
G
R
K
T
Site 90
T1148
T
D
A
R
G
R
K
T
R
Y
D
T
K
V
G
Site 91
Y1150
A
R
G
R
K
T
R
Y
D
T
K
V
G
T
D
Site 92
T1152
G
R
K
T
R
Y
D
T
K
V
G
T
D
K
W
Site 93
T1164
D
K
W
P
K
K
V
T
F
K
A
G
P
R
L
Site 94
S1177
R
L
Q
F
L
F
H
S
D
S
S
H
N
E
W
Site 95
Y1186
S
S
H
N
E
W
G
Y
K
F
T
V
T
A
C
Site 96
S1226
S
Q
C
M
A
L
K
S
V
R
Q
L
G
S
N
Site 97
S1267
P
E
L
E
L
E
A
S
W
P
T
H
P
H
R
Site 98
S1276
P
T
H
P
H
R
N
S
K
E
V
K
N
I
P
Site 99
T1325
C
R
K
Q
A
P
K
T
D
I
V
A
G
S
T
Site 100
Y1352
V
Y
R
T
P
D
L
Y
E
K
L
Q
K
Y
V
Site 101
Y1358
L
Y
E
K
L
Q
K
Y
V
N
S
G
G
K
I
Site 102
S1368
S
G
G
K
I
A
L
S
E
E
F
A
Q
V
Y
Site 103
Y1375
S
E
E
F
A
Q
V
Y
S
L
A
D
G
I
R
Site 104
S1392
M
L
E
M
K
Q
K
S
L
M
S
L
G
N
E
Site 105
S1405
N
E
A
E
E
K
H
S
S
E
A
T
E
V
N
Site 106
S1406
E
A
E
E
K
H
S
S
E
A
T
E
V
N
P
Site 107
T1409
E
K
H
S
S
E
A
T
E
V
N
P
E
S
L
Site 108
S1415
A
T
E
V
N
P
E
S
L
A
K
E
C
I
E
Site 109
S1436
K
F
L
P
T
G
I
S
S
K
E
S
C
E
K
Site 110
S1440
T
G
I
S
S
K
E
S
C
E
K
L
E
T
A
Site 111
T1446
E
S
C
E
K
L
E
T
A
D
E
T
S
H
L
Site 112
T1462
P
L
N
K
R
Q
R
T
S
S
V
V
E
E
H
Site 113
S1463
L
N
K
R
Q
R
T
S
S
V
V
E
E
H
F
Site 114
S1464
N
K
R
Q
R
T
S
S
V
V
E
E
H
F
Q
Site 115
S1473
V
E
E
H
F
Q
A
S
V
S
P
T
E
A
A
Site 116
S1475
E
H
F
Q
A
S
V
S
P
T
E
A
A
P
P
Site 117
T1477
F
Q
A
S
V
S
P
T
E
A
A
P
P
A
T
Site 118
T1484
T
E
A
A
P
P
A
T
G
D
Q
S
P
G
L
Site 119
S1488
P
P
A
T
G
D
Q
S
P
G
L
G
T
Q
P
Site 120
T1493
D
Q
S
P
G
L
G
T
Q
P
K
L
P
S
S
Site 121
S1499
G
T
Q
P
K
L
P
S
S
S
G
L
P
A
A
Site 122
S1500
T
Q
P
K
L
P
S
S
S
G
L
P
A
A
D
Site 123
S1501
Q
P
K
L
P
S
S
S
G
L
P
A
A
D
V
Site 124
S1509
G
L
P
A
A
D
V
S
P
A
T
A
E
E
P
Site 125
T1512
A
A
D
V
S
P
A
T
A
E
E
P
L
S
P
Site 126
S1518
A
T
A
E
E
P
L
S
P
S
T
P
T
R
R
Site 127
S1520
A
E
E
P
L
S
P
S
T
P
T
R
R
P
P
Site 128
T1521
E
E
P
L
S
P
S
T
P
T
R
R
P
P
F
Site 129
T1523
P
L
S
P
S
T
P
T
R
R
P
P
F
T
R
Site 130
T1529
P
T
R
R
P
P
F
T
R
G
R
L
R
L
L
Site 131
S1537
R
G
R
L
R
L
L
S
F
R
S
M
E
E
A
Site 132
S1540
L
R
L
L
S
F
R
S
M
E
E
A
R
L
V
Site 133
Y1554
V
P
T
V
K
E
K
Y
P
V
L
K
D
V
M
Site 134
S1568
M
D
F
I
K
D
Q
S
L
S
H
R
S
V
V
Site 135
S1570
F
I
K
D
Q
S
L
S
H
R
S
V
V
K
V
Site 136
S1573
D
Q
S
L
S
H
R
S
V
V
K
V
L
S
L
Site 137
S1579
R
S
V
V
K
V
L
S
L
R
K
A
Q
A
Q
Site 138
Y1629
C
Q
K
D
F
T
N
Y
F
G
H
L
E
G
C
Site 139
T1647
L
H
K
E
I
R
D
T
Y
Y
Q
L
V
L
F
Site 140
Y1648
H
K
E
I
R
D
T
Y
Y
Q
L
V
L
F
L
Site 141
S1664
K
A
V
K
G
F
S
S
L
N
D
R
S
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Site 142
S1710
P
D
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L
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M
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E
N
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Site 143
S1715
K
M
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N
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Site 144
S1719
E
N
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Site 145
S1722
S
V
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Site 146
S1725
D
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A
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Site 147
Y1752
D
G
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Site 148
Y1856
C
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D
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D
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C
Y
A
A
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Site 149
Y1859
F
D
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C
Y
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A
K
K
Y
S
Y
Site 150
Y1864
G
C
Y
A
A
K
K
Y
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Y
G
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Site 151
T1881
I
T
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R
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Site 152
S1885
P
M
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R
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I
Q
Site 153
Y1894
R
Q
R
L
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Q
P
Y
I
H
N
Y
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W
L
Site 154
T1928
G
E
K
L
D
P
Q
T
R
S
S
A
T
T
L
Site 155
S1931
L
D
P
Q
T
R
S
S
A
T
T
L
R
S
Q
Site 156
T1934
Q
T
R
S
S
A
T
T
L
R
S
Q
C
M
Q
Site 157
S1937
S
S
A
T
T
L
R
S
Q
C
M
Q
L
V
G
Site 158
S1970
G
V
L
P
D
G
D
S
S
L
E
D
Q
A
L
Site 159
S1971
V
L
P
D
G
D
S
S
L
E
D
Q
A
L
P
Site 160
T1980
E
D
Q
A
L
P
V
T
V
P
T
G
A
S
E
Site 161
S2001
A
V
Q
G
A
E
L
S
E
A
G
N
G
K
R
Site 162
S2030
N
K
A
D
K
G
V
S
L
S
K
D
P
S
C
Site 163
S2032
A
D
K
G
V
S
L
S
K
D
P
S
C
Q
T
Site 164
S2036
V
S
L
S
K
D
P
S
C
Q
T
Q
I
S
D
Site 165
S2042
P
S
C
Q
T
Q
I
S
D
S
P
A
D
A
S
Site 166
S2044
C
Q
T
Q
I
S
D
S
P
A
D
A
S
P
P
Site 167
S2049
S
D
S
P
A
D
A
S
P
P
T
G
L
P
D
Site 168
T2052
P
A
D
A
S
P
P
T
G
L
P
D
A
E
D
Site 169
S2060
G
L
P
D
A
E
D
S
E
V
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S
Q
K
P
Site 170
S2064
A
E
D
S
E
V
S
S
Q
K
P
I
E
E
K
Site 171
T2074
P
I
E
E
K
A
V
T
P
S
P
E
Q
V
F
Site 172
S2076
E
E
K
A
V
T
P
S
P
E
Q
V
F
A
E
Site 173
S2085
E
Q
V
F
A
E
C
S
Q
K
R
I
L
G
L
Site 174
S2214
E
I
L
R
S
L
N
S
A
P
L
W
R
D
V
Site 175
Y2263
C
V
G
T
R
C
V
Y
M
D
N
A
N
E
P
Site 176
T2292
A
V
I
V
D
V
K
T
R
K
R
K
T
V
K
Site 177
T2297
V
K
T
R
K
R
K
T
V
K
D
Y
Q
L
V
Site 178
Y2301
K
R
K
T
V
K
D
Y
Q
L
V
Q
K
G
G
Site 179
S2315
G
G
Q
E
C
G
D
S
R
A
Q
L
S
Q
Y
Site 180
S2320
G
D
S
R
A
Q
L
S
Q
Y
S
Q
H
F
A
Site 181
Y2322
S
R
A
Q
L
S
Q
Y
S
Q
H
F
A
F
I
Site 182
S2323
R
A
Q
L
S
Q
Y
S
Q
H
F
A
F
I
A
Site 183
S2336
I
A
S
H
L
L
Q
S
S
M
D
S
H
C
P
Site 184
S2337
A
S
H
L
L
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S
M
D
S
H
C
P
E
Site 185
S2340
L
L
Q
S
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S
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C
P
E
A
V
E
Site 186
Y2360
S
L
A
L
K
G
L
Y
K
T
L
K
A
H
G
Site 187
T2362
A
L
K
G
L
Y
K
T
L
K
A
H
G
F
E
Site 188
S2395
C
S
K
G
T
G
F
S
K
T
W
L
L
R
D
Site 189
T2397
K
G
T
G
F
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K
T
W
L
L
R
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L
E
Site 190
S2407
L
R
D
L
E
I
L
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I
M
L
Y
S
S
K
Site 191
Y2411
E
I
L
S
I
M
L
Y
S
S
K
K
E
I
N
Site 192
S2443
E
E
V
E
R
P
V
S
S
P
G
D
P
E
Q
Site 193
S2444
E
V
E
R
P
V
S
S
P
G
D
P
E
Q
K
Site 194
Y2485
L
H
I
L
R
A
I
Y
E
L
Q
M
K
K
T
Site 195
T2492
Y
E
L
Q
M
K
K
T
D
Y
F
F
L
E
V
Site 196
Y2494
L
Q
M
K
K
T
D
Y
F
F
L
E
V
Q
K
Site 197
T2509
R
F
D
G
D
E
L
T
T
D
E
R
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R
S
Site 198
S2516
T
T
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E
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A
Q
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P
Site 199
S2526
Q
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W
Q
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Site 200
S2533
S
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A
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Site 201
T2557
P
A
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A
T
A
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N
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Site 202
T2564
T
A
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N
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K
L
I
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Site 203
S2569
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S
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Site 204
S2573
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L
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E
L
Q
Q
S
Y
A
Site 205
S2578
T
E
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E
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Q
S
Y
A
K
Q
R
R
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Site 206
S2585
S
Y
A
K
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R
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K
S
A
A
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L
H
Site 207
S2587
A
K
Q
R
R
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K
S
A
A
L
L
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K
E
Site 208
S2599
H
K
E
L
N
C
K
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K
R
A
V
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Y
Site 209
Y2606
S
K
R
A
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Y
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V
N
E
A
Site 210
S2632
S
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Site 211
S2637
W
P
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L
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Site 212
S2644
S
E
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L
S
G
P
A
H
M
T
Y
Site 213
Y2708
V
R
E
S
K
H
P
Y
N
N
N
T
N
F
E
Site 214
S2732
Y
L
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K
F
D
S
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C
N
T
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E
G
Site 215
T2736
K
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N
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G
C
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E
L
Site 216
S2746
G
C
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M
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Q
Site 217
S2747
C
D
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S
S
S
D
F
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Q
D
Site 218
S2748
D
E
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A
M
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S
S
D
F
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Q
D
R
Site 219
S2757
D
F
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Q
D
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G
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Q
K
Site 220
S2759
Q
Q
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Q
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W
K
Site 221
S2761
D
R
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S
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Q
K
W
K
D
F
Site 222
T2774
D
F
E
L
P
G
D
T
L
Y
Y
R
F
T
S
Site 223
Y2776
E
L
P
G
D
T
L
Y
Y
R
F
T
S
D
M
Site 224
Y2777
L
P
G
D
T
L
Y
Y
R
F
T
S
D
M
S
Site 225
T2780
D
T
L
Y
Y
R
F
T
S
D
M
S
N
T
E
Site 226
T2793
T
E
W
G
Y
R
F
T
V
T
A
G
H
L
G
Site 227
T2804
G
H
L
G
R
F
Q
T
G
F
E
I
L
K
Q
Site 228
S2814
E
I
L
K
Q
M
L
S
E
E
R
V
V
P
H
Site 229
T2839
V
G
V
A
C
R
Q
T
G
H
Q
R
L
K
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation