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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DDEF2
Full Name:
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2
Alias:
ArfGAP with SH3 domain, ankyrin repeat and PH domain 2; Centaurin, beta 3; CENTB3; DDF2; Development and differentiation-enhancing factor 2; KIAA0400; PAG3; PAP; Paxillin-associated protein with ARFGAP activity 3; Pyk2 C-terminus associated protein; Pyk2 C-terminus-associated protein 2; SHAG1
Type:
GTPase activating protein, ARF
Mass (Da):
111651
Number AA:
1006
UniProt ID:
O43150
International Prot ID:
IPI00022058
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0019898
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0008060
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0032312
GO:0032318
GO:0043087
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
P
D
Q
I
S
V
S
E
F
V
A
E
T
H
Site 2
Y18
V
A
E
T
H
E
D
Y
K
A
P
T
A
S
S
Site 3
S25
Y
K
A
P
T
A
S
S
F
T
T
R
T
A
Q
Site 4
T36
R
T
A
Q
C
R
N
T
V
A
A
I
E
E
A
Site 5
Y52
D
V
D
R
M
V
L
Y
K
M
K
K
S
V
K
Site 6
S57
V
L
Y
K
M
K
K
S
V
K
A
I
N
S
S
Site 7
T76
V
E
N
E
E
Q
Y
T
Q
A
L
E
K
F
G
Site 8
S96
R
D
D
P
D
L
G
S
A
F
L
K
F
S
V
Site 9
Y153
F
D
K
A
W
K
D
Y
E
T
K
I
T
K
I
Site 10
T158
K
D
Y
E
T
K
I
T
K
I
E
K
E
K
K
Site 11
Y201
F
Q
L
Q
M
C
E
Y
L
L
K
V
N
E
I
Site 12
S240
D
G
L
K
A
V
E
S
L
K
P
S
I
E
T
Site 13
S244
A
V
E
S
L
K
P
S
I
E
T
L
S
T
D
Site 14
T247
S
L
K
P
S
I
E
T
L
S
T
D
L
H
T
Site 15
S249
K
P
S
I
E
T
L
S
T
D
L
H
T
I
K
Site 16
T250
P
S
I
E
T
L
S
T
D
L
H
T
I
K
Q
Site 17
S275
Q
L
R
D
I
L
K
S
A
L
Q
V
E
Q
K
Site 18
S285
Q
V
E
Q
K
E
D
S
Q
I
R
Q
S
T
A
Site 19
S290
E
D
S
Q
I
R
Q
S
T
A
Y
S
L
H
Q
Site 20
T291
D
S
Q
I
R
Q
S
T
A
Y
S
L
H
Q
P
Site 21
Y293
Q
I
R
Q
S
T
A
Y
S
L
H
Q
P
Q
G
Site 22
S294
I
R
Q
S
T
A
Y
S
L
H
Q
P
Q
G
N
Site 23
T306
Q
G
N
K
E
H
G
T
E
R
N
G
S
L
Y
Site 24
S311
H
G
T
E
R
N
G
S
L
Y
K
K
S
D
G
Site 25
Y313
T
E
R
N
G
S
L
Y
K
K
S
D
G
I
R
Site 26
S316
N
G
S
L
Y
K
K
S
D
G
I
R
K
V
W
Site 27
S329
V
W
Q
K
R
K
C
S
V
K
N
G
F
L
T
Site 28
T336
S
V
K
N
G
F
L
T
I
S
H
G
T
A
N
Site 29
S338
K
N
G
F
L
T
I
S
H
G
T
A
N
R
P
Site 30
T353
P
A
K
L
N
L
L
T
C
Q
V
K
T
N
P
Site 31
T374
D
L
I
S
H
D
R
T
Y
H
F
Q
A
E
D
Site 32
Y375
L
I
S
H
D
R
T
Y
H
F
Q
A
E
D
E
Site 33
T410
A
F
K
G
D
D
N
T
G
E
N
N
I
V
Q
Site 34
Y470
H
R
E
L
G
V
H
Y
S
R
M
Q
S
L
T
Site 35
S471
R
E
L
G
V
H
Y
S
R
M
Q
S
L
T
L
Site 36
T477
Y
S
R
M
Q
S
L
T
L
D
V
L
G
T
S
Site 37
S510
C
C
L
P
A
E
D
S
V
K
P
N
P
G
S
Site 38
S517
S
V
K
P
N
P
G
S
D
M
N
A
R
K
D
Site 39
Y525
D
M
N
A
R
K
D
Y
I
T
A
K
Y
I
E
Site 40
T527
N
A
R
K
D
Y
I
T
A
K
Y
I
E
R
R
Site 41
Y530
K
D
Y
I
T
A
K
Y
I
E
R
R
Y
A
R
Site 42
Y535
A
K
Y
I
E
R
R
Y
A
R
K
K
H
A
D
Site 43
T573
Y
A
D
G
V
D
L
T
E
K
I
P
L
A
N
Site 44
T587
N
G
H
E
P
D
E
T
A
L
H
L
A
V
R
Site 45
T618
S
G
N
L
D
K
Q
T
G
K
G
S
T
A
L
Site 46
Y627
K
G
S
T
A
L
H
Y
C
C
L
T
D
N
A
Site 47
S653
S
I
E
I
A
N
E
S
G
E
T
P
L
D
I
Site 48
T656
I
A
N
E
S
G
E
T
P
L
D
I
A
K
R
Site 49
T674
E
H
C
E
E
L
L
T
Q
A
L
S
G
R
F
Site 50
S678
E
L
L
T
Q
A
L
S
G
R
F
N
S
H
V
Site 51
S683
A
L
S
G
R
F
N
S
H
V
H
V
E
Y
E
Site 52
Y689
N
S
H
V
H
V
E
Y
E
W
R
L
L
H
E
Site 53
S701
L
H
E
D
L
D
E
S
D
D
D
M
D
E
K
Site 54
S712
M
D
E
K
L
Q
P
S
P
N
R
R
E
D
R
Site 55
S722
R
R
E
D
R
P
I
S
F
Y
Q
L
G
S
N
Site 56
Y724
E
D
R
P
I
S
F
Y
Q
L
G
S
N
Q
L
Site 57
S728
I
S
F
Y
Q
L
G
S
N
Q
L
Q
S
N
A
Site 58
S733
L
G
S
N
Q
L
Q
S
N
A
V
S
L
A
R
Site 59
S737
Q
L
Q
S
N
A
V
S
L
A
R
D
A
A
N
Site 60
S756
K
Q
R
A
F
M
P
S
I
L
Q
N
E
T
Y
Site 61
Y763
S
I
L
Q
N
E
T
Y
G
A
L
L
S
G
S
Site 62
S768
E
T
Y
G
A
L
L
S
G
S
P
P
P
A
Q
Site 63
S770
Y
G
A
L
L
S
G
S
P
P
P
A
Q
P
A
Site 64
S780
P
A
Q
P
A
A
P
S
T
T
S
A
P
P
L
Site 65
T781
A
Q
P
A
A
P
S
T
T
S
A
P
P
L
P
Site 66
S783
P
A
A
P
S
T
T
S
A
P
P
L
P
P
R
Site 67
S799
V
G
K
V
Q
T
A
S
S
A
N
T
L
W
K
Site 68
S800
G
K
V
Q
T
A
S
S
A
N
T
L
W
K
T
Site 69
T803
Q
T
A
S
S
A
N
T
L
W
K
T
N
S
V
Site 70
T807
S
A
N
T
L
W
K
T
N
S
V
S
V
D
G
Site 71
S809
N
T
L
W
K
T
N
S
V
S
V
D
G
G
S
Site 72
S811
L
W
K
T
N
S
V
S
V
D
G
G
S
R
Q
Site 73
S816
S
V
S
V
D
G
G
S
R
Q
R
S
S
S
D
Site 74
S820
D
G
G
S
R
Q
R
S
S
S
D
P
P
A
V
Site 75
S821
G
G
S
R
Q
R
S
S
S
D
P
P
A
V
H
Site 76
S822
G
S
R
Q
R
S
S
S
D
P
P
A
V
H
P
Site 77
T837
P
L
P
P
L
R
V
T
S
T
N
P
L
T
P
Site 78
S838
L
P
P
L
R
V
T
S
T
N
P
L
T
P
T
Site 79
T839
P
P
L
R
V
T
S
T
N
P
L
T
P
T
P
Site 80
T843
V
T
S
T
N
P
L
T
P
T
P
P
P
P
V
Site 81
T845
S
T
N
P
L
T
P
T
P
P
P
P
V
A
K
Site 82
T853
P
P
P
P
V
A
K
T
P
S
V
M
E
A
L
Site 83
S855
P
P
V
A
K
T
P
S
V
M
E
A
L
S
Q
Site 84
S861
P
S
V
M
E
A
L
S
Q
P
S
K
P
A
P
Site 85
S872
K
P
A
P
P
G
I
S
Q
I
R
P
P
P
L
Site 86
S885
P
L
P
P
Q
P
P
S
R
L
P
Q
K
K
P
Site 87
S899
P
A
P
G
A
D
K
S
T
P
L
T
N
K
G
Site 88
T900
A
P
G
A
D
K
S
T
P
L
T
N
K
G
Q
Site 89
T903
A
D
K
S
T
P
L
T
N
K
G
Q
P
R
G
Site 90
S915
P
R
G
P
V
D
L
S
A
T
E
A
L
G
P
Site 91
S939
P
A
P
M
P
R
K
S
Q
A
T
K
L
K
P
Site 92
Y953
P
K
R
V
K
A
L
Y
N
C
V
A
D
N
P
Site 93
T964
A
D
N
P
D
E
L
T
F
S
E
G
D
V
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation