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Updated November 2019
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Protein Info
Short Name:
TET3
Full Name:
Methylcytosine dioxygenase TET3
Alias:
Type:
Mass (Da):
179350
Number AA:
1660
UniProt ID:
O43151
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y7
_
M
D
S
G
P
V
Y
H
G
D
S
R
Q
L
Site 2
S11
G
P
V
Y
H
G
D
S
R
Q
L
S
A
S
G
Site 3
S15
H
G
D
S
R
Q
L
S
A
S
G
V
P
V
N
Site 4
S17
D
S
R
Q
L
S
A
S
G
V
P
V
N
G
A
Site 5
S31
A
R
E
P
A
G
P
S
L
L
G
T
G
G
P
Site 6
T35
A
G
P
S
L
L
G
T
G
G
P
W
R
V
D
Site 7
S82
V
S
S
Y
G
A
L
S
T
R
L
Y
E
T
F
Site 8
Y86
G
A
L
S
T
R
L
Y
E
T
F
N
R
E
M
Site 9
T88
L
S
T
R
L
Y
E
T
F
N
R
E
M
S
R
Site 10
S94
E
T
F
N
R
E
M
S
R
E
A
G
N
N
S
Site 11
S101
S
R
E
A
G
N
N
S
R
G
P
R
P
G
P
Site 12
Y147
D
G
P
E
C
P
D
Y
L
E
W
L
E
G
K
Site 13
S157
W
L
E
G
K
I
K
S
V
V
M
E
G
G
E
Site 14
S184
E
A
G
L
P
A
P
S
T
R
P
L
L
S
S
Site 15
T185
A
G
L
P
A
P
S
T
R
P
L
L
S
S
E
Site 16
S190
P
S
T
R
P
L
L
S
S
E
V
P
Q
I
S
Site 17
S191
S
T
R
P
L
L
S
S
E
V
P
Q
I
S
P
Site 18
S197
S
S
E
V
P
Q
I
S
P
Q
E
G
L
P
L
Site 19
S207
E
G
L
P
L
S
Q
S
A
L
S
I
A
K
E
Site 20
S210
P
L
S
Q
S
A
L
S
I
A
K
E
K
N
I
Site 21
S233
E
A
L
T
Q
L
S
S
A
L
P
Q
P
S
H
Site 22
S239
S
S
A
L
P
Q
P
S
H
S
T
P
Q
A
S
Site 23
S241
A
L
P
Q
P
S
H
S
T
P
Q
A
S
C
P
Site 24
T242
L
P
Q
P
S
H
S
T
P
Q
A
S
C
P
L
Site 25
S246
S
H
S
T
P
Q
A
S
C
P
L
P
E
A
L
Site 26
S254
C
P
L
P
E
A
L
S
P
P
A
P
F
R
S
Site 27
S261
S
P
P
A
P
F
R
S
P
Q
S
Y
L
R
A
Site 28
S264
A
P
F
R
S
P
Q
S
Y
L
R
A
P
S
W
Site 29
Y265
P
F
R
S
P
Q
S
Y
L
R
A
P
S
W
P
Site 30
S270
Q
S
Y
L
R
A
P
S
W
P
V
V
P
P
E
Site 31
S281
V
P
P
E
E
H
S
S
F
A
P
D
S
S
A
Site 32
S286
H
S
S
F
A
P
D
S
S
A
F
P
P
A
T
Site 33
S287
S
S
F
A
P
D
S
S
A
F
P
P
A
T
P
Site 34
T293
S
S
A
F
P
P
A
T
P
R
T
E
F
P
E
Site 35
T296
F
P
P
A
T
P
R
T
E
F
P
E
A
W
G
Site 36
T304
E
F
P
E
A
W
G
T
D
T
P
P
A
T
P
Site 37
T306
P
E
A
W
G
T
D
T
P
P
A
T
P
R
S
Site 38
T310
G
T
D
T
P
P
A
T
P
R
S
S
W
P
M
Site 39
S313
T
P
P
A
T
P
R
S
S
W
P
M
P
R
P
Site 40
S314
P
P
A
T
P
R
S
S
W
P
M
P
R
P
S
Site 41
S321
S
W
P
M
P
R
P
S
P
D
P
M
A
E
L
Site 42
S334
E
L
E
Q
L
L
G
S
A
S
D
Y
I
Q
S
Site 43
S336
E
Q
L
L
G
S
A
S
D
Y
I
Q
S
V
F
Site 44
Y338
L
L
G
S
A
S
D
Y
I
Q
S
V
F
K
R
Site 45
S341
S
A
S
D
Y
I
Q
S
V
F
K
R
P
E
A
Site 46
T351
K
R
P
E
A
L
P
T
K
P
K
V
K
V
E
Site 47
S361
K
V
K
V
E
A
P
S
S
S
P
A
P
A
P
Site 48
S362
V
K
V
E
A
P
S
S
S
P
A
P
A
P
S
Site 49
S363
K
V
E
A
P
S
S
S
P
A
P
A
P
S
P
Site 50
S369
S
S
P
A
P
A
P
S
P
V
L
Q
R
E
A
Site 51
T378
V
L
Q
R
E
A
P
T
P
S
S
E
P
D
T
Site 52
S381
R
E
A
P
T
P
S
S
E
P
D
T
H
Q
K
Site 53
T385
T
P
S
S
E
P
D
T
H
Q
K
A
Q
T
A
Site 54
S402
Q
H
L
H
H
K
R
S
L
F
L
E
Q
V
H
Site 55
T411
F
L
E
Q
V
H
D
T
S
F
P
A
P
S
E
Site 56
S412
L
E
Q
V
H
D
T
S
F
P
A
P
S
E
P
Site 57
S417
D
T
S
F
P
A
P
S
E
P
S
A
P
G
W
Site 58
S429
P
G
W
W
P
P
P
S
S
P
V
P
R
L
P
Site 59
S430
G
W
W
P
P
P
S
S
P
V
P
R
L
P
D
Site 60
T449
E
K
K
K
K
L
P
T
P
A
G
G
P
V
G
Site 61
S467
A
A
P
G
I
K
P
S
V
R
K
P
I
Q
I
Site 62
S477
K
P
I
Q
I
K
K
S
R
P
R
E
A
Q
P
Site 63
S499
I
V
L
E
G
L
R
S
P
A
S
Q
E
V
Q
Site 64
S502
E
G
L
R
S
P
A
S
Q
E
V
Q
A
H
P
Site 65
S519
P
L
P
A
S
Q
G
S
A
V
P
L
P
P
E
Site 66
S537
A
L
F
A
P
S
P
S
R
D
S
L
L
P
P
Site 67
S540
A
P
S
P
S
R
D
S
L
L
P
P
T
Q
E
Site 68
T545
R
D
S
L
L
P
P
T
Q
E
M
R
S
P
S
Site 69
S550
P
P
T
Q
E
M
R
S
P
S
P
M
T
A
L
Site 70
S552
T
Q
E
M
R
S
P
S
P
M
T
A
L
Q
P
Site 71
S561
M
T
A
L
Q
P
G
S
T
G
P
L
P
P
A
Site 72
S586
F
E
A
E
F
G
D
S
F
G
L
P
G
P
P
Site 73
S594
F
G
L
P
G
P
P
S
V
P
I
Q
D
P
E
Site 74
T605
Q
D
P
E
N
Q
Q
T
C
L
P
A
P
E
S
Site 75
S612
T
C
L
P
A
P
E
S
P
F
A
T
R
S
P
Site 76
T616
A
P
E
S
P
F
A
T
R
S
P
K
Q
I
K
Site 77
S618
E
S
P
F
A
T
R
S
P
K
Q
I
K
I
E
Site 78
T648
E
E
G
G
Q
E
A
T
P
T
K
A
E
N
P
Site 79
T650
G
G
Q
E
A
T
P
T
K
A
E
N
P
L
T
Site 80
T657
T
K
A
E
N
P
L
T
P
T
L
S
G
F
L
Site 81
T659
A
E
N
P
L
T
P
T
L
S
G
F
L
E
S
Site 82
S666
T
L
S
G
F
L
E
S
P
L
K
Y
L
D
T
Site 83
T673
S
P
L
K
Y
L
D
T
P
T
K
S
L
L
D
Site 84
S677
Y
L
D
T
P
T
K
S
L
L
D
T
P
A
K
Site 85
T681
P
T
K
S
L
L
D
T
P
A
K
R
A
Q
A
Site 86
Y707
V
E
K
D
E
G
P
Y
Y
T
H
L
G
S
G
Site 87
Y708
E
K
D
E
G
P
Y
Y
T
H
L
G
S
G
P
Site 88
T709
K
D
E
G
P
Y
Y
T
H
L
G
S
G
P
T
Site 89
S713
P
Y
Y
T
H
L
G
S
G
P
T
V
A
S
I
Site 90
S719
G
S
G
P
T
V
A
S
I
R
E
L
M
E
E
Site 91
Y728
R
E
L
M
E
E
R
Y
G
E
K
G
K
A
I
Site 92
Y742
I
R
I
E
K
V
I
Y
T
G
K
E
G
K
S
Site 93
S749
Y
T
G
K
E
G
K
S
S
R
G
C
P
I
A
Site 94
S750
T
G
K
E
G
K
S
S
R
G
C
P
I
A
K
Site 95
T764
K
W
V
I
R
R
H
T
L
E
E
K
L
L
C
Site 96
S799
A
W
E
G
I
P
R
S
L
G
D
T
L
Y
Q
Site 97
T803
I
P
R
S
L
G
D
T
L
Y
Q
E
L
T
D
Site 98
Y805
R
S
L
G
D
T
L
Y
Q
E
L
T
D
T
L
Site 99
T809
D
T
L
Y
Q
E
L
T
D
T
L
R
K
Y
G
Site 100
T811
L
Y
Q
E
L
T
D
T
L
R
K
Y
G
N
P
Site 101
Y815
L
T
D
T
L
R
K
Y
G
N
P
T
S
R
R
Site 102
T819
L
R
K
Y
G
N
P
T
S
R
R
C
G
L
N
Site 103
S820
R
K
Y
G
N
P
T
S
R
R
C
G
L
N
D
Site 104
T840
C
Q
G
K
D
P
N
T
C
G
A
S
F
S
F
Site 105
Y860
M
Y
F
N
G
C
K
Y
A
R
S
K
T
P
R
Site 106
S863
N
G
C
K
Y
A
R
S
K
T
P
R
K
F
R
Site 107
T865
C
K
Y
A
R
S
K
T
P
R
K
F
R
L
A
Site 108
S885
E
E
E
V
L
R
K
S
F
Q
D
L
A
T
E
Site 109
T891
K
S
F
Q
D
L
A
T
E
V
A
P
L
Y
K
Site 110
Y897
A
T
E
V
A
P
L
Y
K
R
L
A
P
Q
A
Site 111
Y905
K
R
L
A
P
Q
A
Y
Q
N
Q
V
T
N
E
Site 112
Y981
Q
L
H
V
L
P
L
Y
K
M
A
N
T
D
E
Site 113
S1023
R
L
P
E
P
A
K
S
C
R
Q
R
Q
L
E
Site 114
T1048
I
Q
K
E
K
L
S
T
P
E
K
I
K
Q
E
Site 115
S1069
I
T
S
D
P
G
L
S
L
K
G
G
L
S
Q
Site 116
S1075
L
S
L
K
G
G
L
S
Q
Q
G
L
K
P
S
Site 117
S1082
S
Q
Q
G
L
K
P
S
L
K
V
E
P
Q
N
Site 118
S1093
E
P
Q
N
H
F
S
S
F
K
Y
S
G
N
A
Site 119
S1097
H
F
S
S
F
K
Y
S
G
N
A
V
V
E
S
Site 120
S1106
N
A
V
V
E
S
Y
S
V
L
G
N
C
R
P
Site 121
S1114
V
L
G
N
C
R
P
S
D
P
Y
S
M
N
S
Site 122
Y1117
N
C
R
P
S
D
P
Y
S
M
N
S
V
Y
S
Site 123
S1118
C
R
P
S
D
P
Y
S
M
N
S
V
Y
S
Y
Site 124
S1121
S
D
P
Y
S
M
N
S
V
Y
S
Y
H
S
Y
Site 125
Y1123
P
Y
S
M
N
S
V
Y
S
Y
H
S
Y
Y
A
Site 126
Y1125
S
M
N
S
V
Y
S
Y
H
S
Y
Y
A
Q
P
Site 127
S1127
N
S
V
Y
S
Y
H
S
Y
Y
A
Q
P
S
L
Site 128
Y1128
S
V
Y
S
Y
H
S
Y
Y
A
Q
P
S
L
T
Site 129
Y1129
V
Y
S
Y
H
S
Y
Y
A
Q
P
S
L
T
S
Site 130
S1133
H
S
Y
Y
A
Q
P
S
L
T
S
V
N
G
F
Site 131
S1136
Y
A
Q
P
S
L
T
S
V
N
G
F
H
S
K
Site 132
S1142
T
S
V
N
G
F
H
S
K
Y
A
L
P
S
F
Site 133
Y1144
V
N
G
F
H
S
K
Y
A
L
P
S
F
S
Y
Site 134
S1148
H
S
K
Y
A
L
P
S
F
S
Y
Y
G
F
P
Site 135
S1150
K
Y
A
L
P
S
F
S
Y
Y
G
F
P
S
S
Site 136
Y1151
Y
A
L
P
S
F
S
Y
Y
G
F
P
S
S
N
Site 137
Y1152
A
L
P
S
F
S
Y
Y
G
F
P
S
S
N
P
Site 138
S1156
F
S
Y
Y
G
F
P
S
S
N
P
V
F
P
S
Site 139
S1157
S
Y
Y
G
F
P
S
S
N
P
V
F
P
S
Q
Site 140
S1163
S
S
N
P
V
F
P
S
Q
F
L
G
P
G
A
Site 141
S1174
G
P
G
A
W
G
H
S
G
S
S
G
S
F
E
Site 142
S1176
G
A
W
G
H
S
G
S
S
G
S
F
E
K
K
Site 143
S1179
G
H
S
G
S
S
G
S
F
E
K
K
P
D
L
Site 144
S1192
D
L
H
A
L
H
N
S
L
S
P
A
Y
G
G
Site 145
S1194
H
A
L
H
N
S
L
S
P
A
Y
G
G
A
E
Site 146
T1218
P
T
D
A
H
H
P
T
P
H
H
Q
Q
P
A
Site 147
Y1226
P
H
H
Q
Q
P
A
Y
P
G
P
K
E
Y
L
Site 148
Y1232
A
Y
P
G
P
K
E
Y
L
L
P
K
A
P
L
Site 149
S1242
P
K
A
P
L
L
H
S
V
S
R
D
P
S
P
Site 150
S1244
A
P
L
L
H
S
V
S
R
D
P
S
P
F
A
Site 151
S1248
H
S
V
S
R
D
P
S
P
F
A
Q
S
S
N
Site 152
S1254
P
S
P
F
A
Q
S
S
N
C
Y
N
R
S
I
Site 153
Y1257
F
A
Q
S
S
N
C
Y
N
R
S
I
K
Q
E
Site 154
S1260
S
S
N
C
Y
N
R
S
I
K
Q
E
P
V
D
Site 155
T1270
Q
E
P
V
D
P
L
T
Q
A
E
P
V
P
R
Site 156
T1285
D
A
G
K
M
G
K
T
P
L
S
E
V
S
Q
Site 157
S1288
K
M
G
K
T
P
L
S
E
V
S
Q
N
G
G
Site 158
S1291
K
T
P
L
S
E
V
S
Q
N
G
G
P
S
H
Site 159
S1297
V
S
Q
N
G
G
P
S
H
L
W
G
Q
Y
S
Site 160
Y1303
P
S
H
L
W
G
Q
Y
S
G
G
P
S
M
S
Site 161
S1304
S
H
L
W
G
Q
Y
S
G
G
P
S
M
S
P
Site 162
S1308
G
Q
Y
S
G
G
P
S
M
S
P
K
R
T
N
Site 163
S1310
Y
S
G
G
P
S
M
S
P
K
R
T
N
G
V
Site 164
T1314
P
S
M
S
P
K
R
T
N
G
V
G
G
S
W
Site 165
S1320
R
T
N
G
V
G
G
S
W
G
V
F
S
S
G
Site 166
S1325
G
G
S
W
G
V
F
S
S
G
E
S
P
A
I
Site 167
S1329
G
V
F
S
S
G
E
S
P
A
I
V
P
D
K
Site 168
S1367
G
E
G
Q
Q
A
A
S
H
S
G
G
R
L
R
Site 169
S1369
G
Q
Q
A
A
S
H
S
G
G
R
L
R
G
K
Site 170
S1379
R
L
R
G
K
P
W
S
P
C
K
F
G
N
S
Site 171
S1394
T
S
A
L
A
G
P
S
L
T
E
K
P
W
A
Site 172
S1409
L
G
A
G
D
F
N
S
A
L
K
G
S
P
G
Site 173
S1414
F
N
S
A
L
K
G
S
P
G
F
Q
D
K
L
Site 174
S1438
R
I
P
A
A
G
A
S
Q
L
D
R
A
W
Q
Site 175
S1446
Q
L
D
R
A
W
Q
S
F
G
L
P
L
G
S
Site 176
S1463
K
L
F
G
A
L
K
S
E
E
K
L
W
D
P
Site 177
S1472
E
K
L
W
D
P
F
S
L
E
E
G
P
A
E
Site 178
S1483
G
P
A
E
E
P
P
S
K
G
A
V
K
E
E
Site 179
S1505
E
E
E
E
E
L
W
S
D
S
E
H
N
F
L
Site 180
S1507
E
E
E
L
W
S
D
S
E
H
N
F
L
D
E
Site 181
T1540
A
R
R
E
L
H
A
T
T
P
L
K
K
P
N
Site 182
T1541
R
R
E
L
H
A
T
T
P
L
K
K
P
N
R
Site 183
Y1559
T
R
I
S
L
V
F
Y
Q
H
K
N
L
N
Q
Site 184
Y1605
G
Q
Q
E
A
K
L
Y
G
K
K
R
K
W
G
Site 185
T1614
K
K
R
K
W
G
G
T
V
V
A
E
P
Q
Q
Site 186
T1630
E
K
K
G
V
V
P
T
R
Q
A
L
A
V
P
Site 187
Y1649
V
T
V
S
S
Y
A
Y
T
K
V
T
G
P
Y
Site 188
T1650
T
V
S
S
Y
A
Y
T
K
V
T
G
P
Y
S
Site 189
T1653
S
Y
A
Y
T
K
V
T
G
P
Y
S
R
W
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation