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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PJA2
Full Name:
E3 ubiquitin-protein ligase Praja-2
Alias:
EC 6.3.2.-; KIAA0438; Neurodap1; Praja 2, RING-H2 motif containing; Praja ring finger 2; Praja-2; RING finger protein 131; RNF131
Type:
Ubiquitin ligase; Ligase; Ubiquitin conjugating system; EC 6.3.2.-
Mass (Da):
78214
Number AA:
708
UniProt ID:
O43164
International Prot ID:
IPI00006557
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0030054
GO:0005783
Uniprot
OncoNet
Molecular Function:
GO:0016874
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0019941
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S16
P
A
A
M
D
Q
E
S
G
K
A
V
W
P
K
Site 2
Y28
W
P
K
P
A
G
G
Y
Q
T
I
T
G
R
R
Site 3
T32
A
G
G
Y
Q
T
I
T
G
R
R
Y
G
R
R
Site 4
Y36
Q
T
I
T
G
R
R
Y
G
R
R
H
A
Y
V
Site 5
Y42
R
Y
G
R
R
H
A
Y
V
S
F
K
P
C
M
Site 6
S55
C
M
T
R
H
E
R
S
L
G
R
A
G
D
D
Site 7
Y63
L
G
R
A
G
D
D
Y
E
V
L
E
L
D
D
Site 8
S76
D
D
V
P
K
E
N
S
S
G
S
S
P
L
D
Site 9
S77
D
V
P
K
E
N
S
S
G
S
S
P
L
D
Q
Site 10
S80
K
E
N
S
S
G
S
S
P
L
D
Q
V
D
S
Site 11
S87
S
P
L
D
Q
V
D
S
S
L
P
S
E
P
I
Site 12
S88
P
L
D
Q
V
D
S
S
L
P
S
E
P
I
F
Site 13
S91
Q
V
D
S
S
L
P
S
E
P
I
F
E
K
S
Site 14
S98
S
E
P
I
F
E
K
S
E
T
E
I
P
T
C
Site 15
T100
P
I
F
E
K
S
E
T
E
I
P
T
C
G
S
Site 16
T112
C
G
S
A
L
N
Q
T
T
E
S
S
Q
S
F
Site 17
T113
G
S
A
L
N
Q
T
T
E
S
S
Q
S
F
V
Site 18
S115
A
L
N
Q
T
T
E
S
S
Q
S
F
V
A
V
Site 19
S116
L
N
Q
T
T
E
S
S
Q
S
F
V
A
V
H
Site 20
S118
Q
T
T
E
S
S
Q
S
F
V
A
V
H
H
S
Site 21
S125
S
F
V
A
V
H
H
S
E
E
G
R
D
T
L
Site 22
T131
H
S
E
E
G
R
D
T
L
G
S
S
T
N
L
Site 23
S134
E
G
R
D
T
L
G
S
S
T
N
L
H
N
H
Site 24
Y146
H
N
H
S
E
G
E
Y
I
P
G
A
C
S
A
Site 25
S152
E
Y
I
P
G
A
C
S
A
S
S
V
Q
N
G
Site 26
T165
N
G
I
A
L
V
H
T
D
S
Y
D
P
D
G
Site 27
S167
I
A
L
V
H
T
D
S
Y
D
P
D
G
K
H
Site 28
Y168
A
L
V
H
T
D
S
Y
D
P
D
G
K
H
G
Site 29
S184
D
N
D
H
L
Q
L
S
A
E
V
V
E
G
S
Site 30
S191
S
A
E
V
V
E
G
S
R
Y
Q
E
S
L
G
Site 31
Y193
E
V
V
E
G
S
R
Y
Q
E
S
L
G
N
T
Site 32
S196
E
G
S
R
Y
Q
E
S
L
G
N
T
V
F
E
Site 33
T200
Y
Q
E
S
L
G
N
T
V
F
E
L
E
N
R
Site 34
Y212
E
N
R
E
A
E
A
Y
T
G
L
S
P
P
V
Site 35
S216
A
E
A
Y
T
G
L
S
P
P
V
P
S
F
N
Site 36
S221
G
L
S
P
P
V
P
S
F
N
C
E
V
R
D
Site 37
S235
D
E
F
E
E
L
D
S
V
P
L
V
K
S
S
Site 38
S241
D
S
V
P
L
V
K
S
S
A
G
D
T
E
F
Site 39
T246
V
K
S
S
A
G
D
T
E
F
V
H
Q
N
S
Site 40
S253
T
E
F
V
H
Q
N
S
Q
E
I
Q
R
S
S
Site 41
S260
S
Q
E
I
Q
R
S
S
Q
D
E
M
V
S
T
Site 42
T267
S
Q
D
E
M
V
S
T
K
Q
Q
N
N
T
S
Site 43
S274
T
K
Q
Q
N
N
T
S
Q
E
R
Q
T
E
H
Site 44
T279
N
T
S
Q
E
R
Q
T
E
H
S
P
E
D
A
Site 45
S282
Q
E
R
Q
T
E
H
S
P
E
D
A
A
C
G
Site 46
S309
R
E
K
N
H
G
S
S
P
E
Q
V
V
R
P
Site 47
S323
P
K
V
R
K
L
I
S
S
S
Q
V
D
Q
E
Site 48
S324
K
V
R
K
L
I
S
S
S
Q
V
D
Q
E
T
Site 49
S325
V
R
K
L
I
S
S
S
Q
V
D
Q
E
T
G
Site 50
S342
R
H
E
A
K
Q
R
S
V
Q
R
W
R
E
A
Site 51
S355
E
A
L
E
V
E
E
S
G
S
D
D
L
L
I
Site 52
S357
L
E
V
E
E
S
G
S
D
D
L
L
I
K
C
Site 53
Y367
L
L
I
K
C
E
E
Y
D
G
E
H
D
C
M
Site 54
Y380
C
M
F
L
D
P
P
Y
S
R
V
I
T
Q
R
Site 55
S381
M
F
L
D
P
P
Y
S
R
V
I
T
Q
R
E
Site 56
T385
P
P
Y
S
R
V
I
T
Q
R
E
T
E
N
N
Site 57
T389
R
V
I
T
Q
R
E
T
E
N
N
Q
M
T
S
Site 58
Y418
F
W
N
G
C
G
D
Y
Y
Q
L
Y
D
K
D
Site 59
Y419
W
N
G
C
G
D
Y
Y
Q
L
Y
D
K
D
E
Site 60
Y422
C
G
D
Y
Y
Q
L
Y
D
K
D
E
D
S
S
Site 61
S428
L
Y
D
K
D
E
D
S
S
E
C
S
D
G
E
Site 62
S429
Y
D
K
D
E
D
S
S
E
C
S
D
G
E
W
Site 63
S432
D
E
D
S
S
E
C
S
D
G
E
W
S
A
S
Site 64
S439
S
D
G
E
W
S
A
S
L
P
H
R
F
S
G
Site 65
S445
A
S
L
P
H
R
F
S
G
T
E
K
D
Q
S
Site 66
T447
L
P
H
R
F
S
G
T
E
K
D
Q
S
S
S
Site 67
S452
S
G
T
E
K
D
Q
S
S
S
D
E
S
W
E
Site 68
S453
G
T
E
K
D
Q
S
S
S
D
E
S
W
E
T
Site 69
S454
T
E
K
D
Q
S
S
S
D
E
S
W
E
T
L
Site 70
S457
D
Q
S
S
S
D
E
S
W
E
T
L
P
G
K
Site 71
T460
S
S
D
E
S
W
E
T
L
P
G
K
D
E
N
Site 72
S473
E
N
E
P
E
L
Q
S
D
S
S
G
P
E
E
Site 73
S475
E
P
E
L
Q
S
D
S
S
G
P
E
E
E
N
Site 74
S476
P
E
L
Q
S
D
S
S
G
P
E
E
E
N
Q
Site 75
S486
E
E
E
N
Q
E
L
S
L
Q
E
G
E
Q
T
Site 76
T493
S
L
Q
E
G
E
Q
T
S
L
E
E
G
E
I
Site 77
S494
L
Q
E
G
E
Q
T
S
L
E
E
G
E
I
P
Site 78
Y505
G
E
I
P
W
L
Q
Y
N
E
V
N
E
S
S
Site 79
S511
Q
Y
N
E
V
N
E
S
S
S
D
E
G
N
E
Site 80
S540
N
N
N
L
E
D
D
S
S
V
S
E
D
L
D
Site 81
S541
N
N
L
E
D
D
S
S
V
S
E
D
L
D
V
Site 82
S551
E
D
L
D
V
D
W
S
L
F
D
G
F
A
D
Site 83
Y576
V
D
P
Q
F
L
T
Y
M
A
L
E
E
R
L
Site 84
S609
E
V
A
N
P
P
A
S
K
E
S
I
D
G
L
Site 85
T619
S
I
D
G
L
P
E
T
L
V
L
E
D
H
T
Site 86
S686
P
P
A
V
I
E
A
S
A
A
P
S
S
E
P
Site 87
S690
I
E
A
S
A
A
P
S
S
E
P
D
P
D
A
Site 88
S691
E
A
S
A
A
P
S
S
E
P
D
P
D
A
P
Site 89
S700
P
D
P
D
A
P
P
S
N
D
S
I
A
E
A
Site 90
S703
D
A
P
P
S
N
D
S
I
A
E
A
P
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation