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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ARHGAP6
Full Name:
Rho GTPase-activating protein 6
Alias:
RHG06; Rho GTPase activating protein 6; RHOGAP6; RhoGAPX-1; Rho-type GTPase-activating protein RhoGAPX-1
Type:
GTPase activating protein, Rac/Rho
Mass (Da):
105947
Number AA:
974
UniProt ID:
O43182
International Prot ID:
IPI00011219
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005884
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005100
GO:0017124
GO:0005070
PhosphoSite+
KinaseNET
Biological Process:
GO:0007266
GO:0030041
GO:0007202
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S15
H
S
V
F
S
C
S
S
P
A
S
S
S
A
A
Site 2
S18
F
S
C
S
S
P
A
S
S
S
A
A
S
A
K
Site 3
S19
S
C
S
S
P
A
S
S
S
A
A
S
A
K
G
Site 4
S20
C
S
S
P
A
S
S
S
A
A
S
A
K
G
F
Site 5
S23
P
A
S
S
S
A
A
S
A
K
G
F
S
K
R
Site 6
S28
A
A
S
A
K
G
F
S
K
R
K
L
R
Q
T
Site 7
T35
S
K
R
K
L
R
Q
T
R
S
L
D
P
A
L
Site 8
S37
R
K
L
R
Q
T
R
S
L
D
P
A
L
I
G
Site 9
S56
D
E
A
G
A
E
G
S
A
R
G
A
T
A
G
Site 10
T61
E
G
S
A
R
G
A
T
A
G
R
L
Y
S
P
Site 11
Y66
G
A
T
A
G
R
L
Y
S
P
S
L
P
A
E
Site 12
S67
A
T
A
G
R
L
Y
S
P
S
L
P
A
E
S
Site 13
S69
A
G
R
L
Y
S
P
S
L
P
A
E
S
L
G
Site 14
S74
S
P
S
L
P
A
E
S
L
G
P
R
L
A
S
Site 15
S81
S
L
G
P
R
L
A
S
S
S
R
G
P
P
P
Site 16
S82
L
G
P
R
L
A
S
S
S
R
G
P
P
P
R
Site 17
S83
G
P
R
L
A
S
S
S
R
G
P
P
P
R
A
Site 18
T91
R
G
P
P
P
R
A
T
R
L
P
P
P
G
P
Site 19
S101
P
P
P
G
P
L
C
S
S
F
S
T
P
S
T
Site 20
S102
P
P
G
P
L
C
S
S
F
S
T
P
S
T
P
Site 21
S104
G
P
L
C
S
S
F
S
T
P
S
T
P
Q
E
Site 22
T105
P
L
C
S
S
F
S
T
P
S
T
P
Q
E
K
Site 23
S107
C
S
S
F
S
T
P
S
T
P
Q
E
K
S
P
Site 24
T108
S
S
F
S
T
P
S
T
P
Q
E
K
S
P
S
Site 25
S113
P
S
T
P
Q
E
K
S
P
S
G
S
F
H
F
Site 26
S115
T
P
Q
E
K
S
P
S
G
S
F
H
F
D
Y
Site 27
S117
Q
E
K
S
P
S
G
S
F
H
F
D
Y
E
V
Site 28
Y122
S
G
S
F
H
F
D
Y
E
V
P
L
G
R
G
Site 29
S134
G
R
G
G
L
K
K
S
M
A
W
D
L
P
S
Site 30
S151
A
G
P
A
S
S
R
S
A
S
S
I
L
C
S
Site 31
S153
P
A
S
S
R
S
A
S
S
I
L
C
S
S
G
Site 32
S154
A
S
S
R
S
A
S
S
I
L
C
S
S
G
G
Site 33
S158
S
A
S
S
I
L
C
S
S
G
G
G
P
N
G
Site 34
S169
G
P
N
G
I
F
A
S
P
R
R
W
L
Q
Q
Site 35
S181
L
Q
Q
R
K
F
Q
S
P
P
D
S
R
G
H
Site 36
S185
K
F
Q
S
P
P
D
S
R
G
H
P
Y
V
V
Site 37
Y190
P
D
S
R
G
H
P
Y
V
V
W
K
S
E
G
Site 38
S203
E
G
D
F
T
W
N
S
M
S
G
R
S
V
R
Site 39
S205
D
F
T
W
N
S
M
S
G
R
S
V
R
L
R
Site 40
S208
W
N
S
M
S
G
R
S
V
R
L
R
S
V
P
Site 41
S213
G
R
S
V
R
L
R
S
V
P
I
Q
S
L
S
Site 42
S218
L
R
S
V
P
I
Q
S
L
S
E
L
E
R
A
Site 43
S220
S
V
P
I
Q
S
L
S
E
L
E
R
A
R
L
Site 44
Y233
R
L
Q
E
V
A
F
Y
Q
L
Q
Q
D
C
D
Site 45
T246
C
D
L
S
C
Q
I
T
I
P
K
D
G
Q
K
Site 46
S257
D
G
Q
K
R
K
K
S
L
R
K
K
L
D
S
Site 47
S264
S
L
R
K
K
L
D
S
L
G
K
E
K
N
K
Site 48
S285
Q
A
F
G
M
P
L
S
Q
V
I
A
N
D
R
Site 49
Y294
V
I
A
N
D
R
A
Y
K
L
K
Q
D
L
Q
Site 50
S309
R
D
E
Q
K
D
A
S
D
F
V
A
S
L
L
Site 51
S328
K
R
Q
N
K
E
L
S
S
S
N
S
S
L
S
Site 52
S329
R
Q
N
K
E
L
S
S
S
N
S
S
L
S
S
Site 53
S330
Q
N
K
E
L
S
S
S
N
S
S
L
S
S
T
Site 54
S332
K
E
L
S
S
S
N
S
S
L
S
S
T
S
E
Site 55
S333
E
L
S
S
S
N
S
S
L
S
S
T
S
E
T
Site 56
S335
S
S
S
N
S
S
L
S
S
T
S
E
T
P
N
Site 57
S336
S
S
N
S
S
L
S
S
T
S
E
T
P
N
E
Site 58
T337
S
N
S
S
L
S
S
T
S
E
T
P
N
E
S
Site 59
S338
N
S
S
L
S
S
T
S
E
T
P
N
E
S
T
Site 60
T340
S
L
S
S
T
S
E
T
P
N
E
S
T
S
P
Site 61
S344
T
S
E
T
P
N
E
S
T
S
P
N
T
P
E
Site 62
S346
E
T
P
N
E
S
T
S
P
N
T
P
E
P
A
Site 63
T349
N
E
S
T
S
P
N
T
P
E
P
A
P
R
A
Site 64
S363
A
R
R
R
G
A
M
S
V
D
S
I
T
D
L
Site 65
S366
R
G
A
M
S
V
D
S
I
T
D
L
D
D
N
Site 66
T368
A
M
S
V
D
S
I
T
D
L
D
D
N
Q
S
Site 67
S375
T
D
L
D
D
N
Q
S
R
L
L
E
A
L
Q
Site 68
S402
K
A
R
D
K
K
L
S
L
N
P
I
Y
R
Q
Site 69
Y407
K
L
S
L
N
P
I
Y
R
Q
V
P
R
L
V
Site 70
S416
Q
V
P
R
L
V
D
S
C
C
Q
H
L
E
K
Site 71
S436
V
G
I
F
R
V
G
S
S
K
K
R
V
R
Q
Site 72
S437
G
I
F
R
V
G
S
S
K
K
R
V
R
Q
L
Site 73
S455
F
D
R
G
I
D
V
S
L
E
E
E
H
S
V
Site 74
S461
V
S
L
E
E
E
H
S
V
H
D
V
A
A
L
Site 75
S568
N
L
L
H
K
Q
K
S
S
D
K
E
F
S
V
Site 76
S569
L
L
H
K
Q
K
S
S
D
K
E
F
S
V
Q
Site 77
S574
K
S
S
D
K
E
F
S
V
Q
S
S
A
R
A
Site 78
S578
K
E
F
S
V
Q
S
S
A
R
A
E
E
S
T
Site 79
S615
L
Q
N
E
V
L
I
S
L
L
E
T
D
P
D
Site 80
Y626
T
D
P
D
V
V
D
Y
L
L
R
R
K
A
S
Site 81
S633
Y
L
L
R
R
K
A
S
Q
S
S
S
P
D
M
Site 82
S635
L
R
R
K
A
S
Q
S
S
S
P
D
M
L
Q
Site 83
S637
R
K
A
S
Q
S
S
S
P
D
M
L
Q
S
E
Site 84
S643
S
S
P
D
M
L
Q
S
E
V
S
F
S
V
G
Site 85
S646
D
M
L
Q
S
E
V
S
F
S
V
G
G
R
H
Site 86
S648
L
Q
S
E
V
S
F
S
V
G
G
R
H
S
S
Site 87
S654
F
S
V
G
G
R
H
S
S
T
D
S
N
K
A
Site 88
S655
S
V
G
G
R
H
S
S
T
D
S
N
K
A
S
Site 89
T656
V
G
G
R
H
S
S
T
D
S
N
K
A
S
S
Site 90
S658
G
R
H
S
S
T
D
S
N
K
A
S
S
G
D
Site 91
S662
S
T
D
S
N
K
A
S
S
G
D
I
S
P
Y
Site 92
S663
T
D
S
N
K
A
S
S
G
D
I
S
P
Y
D
Site 93
S667
K
A
S
S
G
D
I
S
P
Y
D
N
N
S
P
Site 94
Y669
S
S
G
D
I
S
P
Y
D
N
N
S
P
V
L
Site 95
S673
I
S
P
Y
D
N
N
S
P
V
L
S
E
R
S
Site 96
S677
D
N
N
S
P
V
L
S
E
R
S
L
L
A
M
Site 97
S680
S
P
V
L
S
E
R
S
L
L
A
M
Q
E
D
Site 98
Y697
P
G
G
S
E
K
L
Y
R
V
P
G
Q
F
M
Site 99
S710
F
M
L
V
G
H
L
S
S
S
K
S
R
E
S
Site 100
S711
M
L
V
G
H
L
S
S
S
K
S
R
E
S
S
Site 101
S712
L
V
G
H
L
S
S
S
K
S
R
E
S
S
P
Site 102
S714
G
H
L
S
S
S
K
S
R
E
S
S
P
G
P
Site 103
S717
S
S
S
K
S
R
E
S
S
P
G
P
R
L
G
Site 104
S718
S
S
K
S
R
E
S
S
P
G
P
R
L
G
K
Site 105
S728
P
R
L
G
K
D
L
S
E
E
P
F
D
I
W
Site 106
S740
D
I
W
G
T
W
H
S
T
L
K
S
G
S
K
Site 107
T741
I
W
G
T
W
H
S
T
L
K
S
G
S
K
D
Site 108
S744
T
W
H
S
T
L
K
S
G
S
K
D
P
G
M
Site 109
S746
H
S
T
L
K
S
G
S
K
D
P
G
M
T
G
Site 110
S754
K
D
P
G
M
T
G
S
S
G
D
I
F
E
S
Site 111
S761
S
S
G
D
I
F
E
S
S
S
L
R
A
G
P
Site 112
S762
S
G
D
I
F
E
S
S
S
L
R
A
G
P
C
Site 113
S763
G
D
I
F
E
S
S
S
L
R
A
G
P
C
S
Site 114
S770
S
L
R
A
G
P
C
S
L
S
Q
G
N
L
S
Site 115
S772
R
A
G
P
C
S
L
S
Q
G
N
L
S
P
N
Site 116
S777
S
L
S
Q
G
N
L
S
P
N
W
P
R
W
Q
Site 117
S786
N
W
P
R
W
Q
G
S
P
A
E
L
D
S
D
Site 118
S792
G
S
P
A
E
L
D
S
D
T
Q
G
A
R
R
Site 119
T794
P
A
E
L
D
S
D
T
Q
G
A
R
R
T
Q
Site 120
T800
D
T
Q
G
A
R
R
T
Q
A
A
A
P
A
T
Site 121
S816
G
R
A
H
P
A
V
S
R
A
C
S
T
P
H
Site 122
S820
P
A
V
S
R
A
C
S
T
P
H
V
Q
V
A
Site 123
T821
A
V
S
R
A
C
S
T
P
H
V
Q
V
A
G
Site 124
T834
A
G
K
A
E
R
P
T
A
R
S
E
Q
Y
L
Site 125
S837
A
E
R
P
T
A
R
S
E
Q
Y
L
T
L
S
Site 126
Y840
P
T
A
R
S
E
Q
Y
L
T
L
S
G
A
H
Site 127
T842
A
R
S
E
Q
Y
L
T
L
S
G
A
H
D
L
Site 128
S844
S
E
Q
Y
L
T
L
S
G
A
H
D
L
S
E
Site 129
S850
L
S
G
A
H
D
L
S
E
S
E
L
D
V
A
Site 130
T864
A
G
L
Q
S
R
A
T
P
Q
C
Q
R
P
H
Site 131
S873
Q
C
Q
R
P
H
G
S
G
R
D
D
K
R
P
Site 132
Y884
D
K
R
P
P
P
P
Y
P
G
P
G
K
P
A
Site 133
T906
G
P
P
E
G
V
E
T
P
T
D
Q
G
G
Q
Site 134
T922
A
E
R
E
Q
Q
V
T
Q
K
K
L
S
S
A
Site 135
S927
Q
V
T
Q
K
K
L
S
S
A
N
S
L
P
A
Site 136
S928
V
T
Q
K
K
L
S
S
A
N
S
L
P
A
G
Site 137
S931
K
K
L
S
S
A
N
S
L
P
A
G
E
Q
D
Site 138
S939
L
P
A
G
E
Q
D
S
P
R
L
G
D
A
G
Site 139
T963
Q
I
W
E
L
L
S
T
D
N
P
D
A
L
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation