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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ADAM12
Full Name:
Disintegrin and metalloproteinase domain-containing protein 12
Alias:
Meltrin-alpha
Type:
Protease
Mass (Da):
99641
Number AA:
909
UniProt ID:
O43184
International Prot ID:
IPI00415037
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005576
GO:0016021
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0017124
GO:0004222
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0007155
GO:0007520
GO:0006508
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S32
P
C
E
A
R
G
V
S
L
W
N
Q
G
R
A
Site 2
S44
G
R
A
D
E
V
V
S
A
S
V
G
S
G
D
Site 3
S58
D
L
W
I
P
V
K
S
F
D
S
K
N
H
P
Site 4
S76
N
I
R
L
Q
R
E
S
K
E
L
I
I
N
L
Site 5
S92
R
N
E
G
L
I
A
S
S
F
T
E
T
H
Y
Site 6
S93
N
E
G
L
I
A
S
S
F
T
E
T
H
Y
L
Site 7
Y99
S
S
F
T
E
T
H
Y
L
Q
D
G
T
D
V
Site 8
S107
L
Q
D
G
T
D
V
S
L
A
R
N
Y
T
V
Site 9
Y121
V
I
L
G
H
C
Y
Y
H
G
H
V
R
G
Y
Site 10
Y128
Y
H
G
H
V
R
G
Y
S
D
S
A
V
S
L
Site 11
S129
H
G
H
V
R
G
Y
S
D
S
A
V
S
L
S
Site 12
S131
H
V
R
G
Y
S
D
S
A
V
S
L
S
T
C
Site 13
S136
S
D
S
A
V
S
L
S
T
C
S
G
L
R
G
Site 14
Y152
I
V
F
E
N
E
S
Y
V
L
E
P
M
K
S
Site 15
S159
Y
V
L
E
P
M
K
S
A
T
N
R
Y
K
L
Site 16
T161
L
E
P
M
K
S
A
T
N
R
Y
K
L
F
P
Site 17
S174
F
P
A
K
K
L
K
S
V
R
G
S
C
G
S
Site 18
S178
K
L
K
S
V
R
G
S
C
G
S
H
H
N
T
Site 19
S181
S
V
R
G
S
C
G
S
H
H
N
T
P
N
L
Site 20
T185
S
C
G
S
H
H
N
T
P
N
L
A
A
K
N
Site 21
S198
K
N
V
F
P
P
P
S
Q
T
W
A
R
R
H
Site 22
T200
V
F
P
P
P
S
Q
T
W
A
R
R
H
K
R
Site 23
T745
L
F
T
N
K
K
T
T
I
E
K
L
R
C
V
Site 24
S755
K
L
R
C
V
R
P
S
R
P
P
R
G
F
Q
Site 25
S782
L
M
R
K
P
P
D
S
Y
P
P
K
D
N
P
Site 26
Y783
M
R
K
P
P
D
S
Y
P
P
K
D
N
P
R
Site 27
S814
L
N
V
P
Q
P
Q
S
T
Q
R
V
L
P
P
Site 28
T815
N
V
P
Q
P
Q
S
T
Q
R
V
L
P
P
L
Site 29
S830
H
R
A
P
R
A
P
S
V
P
A
R
P
L
P
Site 30
T848
A
L
R
Q
A
Q
G
T
C
K
P
N
P
P
Q
Site 31
T867
A
D
P
L
A
R
T
T
R
L
T
H
A
L
A
Site 32
T870
L
A
R
T
T
R
L
T
H
A
L
A
R
T
P
Site 33
T876
L
T
H
A
L
A
R
T
P
G
Q
W
E
T
G
Site 34
Y895
P
L
R
P
A
P
Q
Y
P
H
Q
V
P
R
S
Site 35
T903
P
H
Q
V
P
R
S
T
H
T
A
Y
I
K
_
Site 36
Y907
P
R
S
T
H
T
A
Y
I
K
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation