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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PSMD3
Full Name:
26S proteasome non-ATPase regulatory subunit 3
Alias:
26S proteasome regulatory subunit S3; P58; Proteasome (prosome, macropain) 26S subunit, non-ATPase, 3; Proteasome subunit p58; PSD3; Rpn3; S3
Type:
Proteasome complex; Protease
Mass (Da):
60978
Number AA:
534
UniProt ID:
O43242
International Prot ID:
IPI00011603
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000502
Uniprot
OncoNet
Molecular Function:
GO:0030234
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0031145
GO:0051436
GO:0051437
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
K
Q
E
G
S
A
R
R
R
G
A
D
Site 2
T43
E
M
K
E
E
A
A
T
G
G
G
S
T
G
E
Site 3
T55
T
G
E
A
D
G
K
T
A
A
A
A
A
E
H
Site 4
S63
A
A
A
A
A
E
H
S
Q
R
E
L
D
T
V
Site 5
T69
H
S
Q
R
E
L
D
T
V
T
L
E
D
I
K
Site 6
T71
Q
R
E
L
D
T
V
T
L
E
D
I
K
E
H
Site 7
S87
K
Q
L
E
K
A
V
S
G
K
E
P
R
F
V
Site 8
S103
R
A
L
R
M
L
P
S
T
S
R
R
L
N
H
Site 9
T104
A
L
R
M
L
P
S
T
S
R
R
L
N
H
Y
Site 10
S105
L
R
M
L
P
S
T
S
R
R
L
N
H
Y
V
Site 11
Y111
T
S
R
R
L
N
H
Y
V
L
Y
K
A
V
Q
Site 12
S123
A
V
Q
G
F
F
T
S
N
N
A
T
R
D
F
Site 13
T141
F
L
E
E
P
M
D
T
E
A
D
L
Q
F
R
Site 14
T151
D
L
Q
F
R
P
R
T
G
K
A
A
S
T
P
Site 15
S156
P
R
T
G
K
A
A
S
T
P
L
L
P
E
V
Site 16
T157
R
T
G
K
A
A
S
T
P
L
L
P
E
V
E
Site 17
Y213
V
A
A
K
C
Y
Y
Y
H
A
R
V
Y
E
F
Site 18
Y218
Y
Y
Y
H
A
R
V
Y
E
F
L
D
K
L
D
Site 19
S229
D
K
L
D
V
V
R
S
F
L
H
A
R
L
R
Site 20
T237
F
L
H
A
R
L
R
T
A
T
L
R
H
D
A
Site 21
T239
H
A
R
L
R
T
A
T
L
R
H
D
A
D
G
Site 22
Y258
L
N
L
L
L
R
N
Y
L
H
Y
S
L
Y
D
Site 23
Y261
L
L
R
N
Y
L
H
Y
S
L
Y
D
Q
A
E
Site 24
S262
L
R
N
Y
L
H
Y
S
L
Y
D
Q
A
E
K
Site 25
Y264
N
Y
L
H
Y
S
L
Y
D
Q
A
E
K
L
V
Site 26
S272
D
Q
A
E
K
L
V
S
K
S
V
F
P
E
Q
Site 27
S274
A
E
K
L
V
S
K
S
V
F
P
E
Q
A
N
Site 28
Y288
N
N
N
E
W
A
R
Y
L
Y
Y
T
G
R
I
Site 29
Y290
N
E
W
A
R
Y
L
Y
Y
T
G
R
I
K
A
Site 30
Y302
I
K
A
I
Q
L
E
Y
S
E
A
R
R
T
M
Site 31
S303
K
A
I
Q
L
E
Y
S
E
A
R
R
T
M
T
Site 32
T308
E
Y
S
E
A
R
R
T
M
T
N
A
L
R
K
Site 33
T310
S
E
A
R
R
T
M
T
N
A
L
R
K
A
P
Site 34
S352
R
L
Q
F
R
Q
P
S
L
K
R
S
L
M
P
Site 35
S356
R
Q
P
S
L
K
R
S
L
M
P
Y
F
L
L
Site 36
T391
E
K
F
Q
A
D
G
T
Y
T
L
I
I
R
L
Site 37
Y392
K
F
Q
A
D
G
T
Y
T
L
I
I
R
L
R
Site 38
T393
F
Q
A
D
G
T
Y
T
L
I
I
R
L
R
H
Site 39
S411
K
T
G
V
R
M
I
S
L
S
Y
S
R
I
S
Site 40
S418
S
L
S
Y
S
R
I
S
L
A
D
I
A
Q
K
Site 41
S430
A
Q
K
L
Q
L
D
S
P
E
D
A
E
F
I
Site 42
Y457
S
I
N
H
E
K
G
Y
V
Q
S
K
E
M
I
Site 43
Y467
S
K
E
M
I
D
I
Y
S
T
R
E
P
Q
L
Site 44
S468
K
E
M
I
D
I
Y
S
T
R
E
P
Q
L
A
Site 45
T469
E
M
I
D
I
Y
S
T
R
E
P
Q
L
A
F
Site 46
S500
A
M
R
F
P
P
K
S
Y
N
K
D
L
E
S
Site 47
S507
S
Y
N
K
D
L
E
S
A
E
E
R
R
E
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation