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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ZW10
Full Name:
Centromere/kinetochore protein zw10 homolog
Alias:
KNTC1AP; ZW10, kinetochore associated; ZW10, kinetochore associated,
Type:
Cell cycle regulation
Mass (Da):
88829
Number AA:
779
UniProt ID:
O43264
International Prot ID:
IPI00011631
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000777
GO:0005783
GO:0019898
Uniprot
OncoNet
Molecular Function:
GO:0019237
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006888
GO:0051301
GO:0000132
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
V
T
E
V
L
A
H
S
G
R
L
E
K
E
D
Site 2
T22
L
E
K
E
D
L
G
T
R
I
S
R
L
T
R
Site 3
S25
E
D
L
G
T
R
I
S
R
L
T
R
R
V
E
Site 4
T28
G
T
R
I
S
R
L
T
R
R
V
E
E
I
K
Site 5
Y46
C
N
M
I
S
K
K
Y
S
E
F
L
P
S
M
Site 6
S47
N
M
I
S
K
K
Y
S
E
F
L
P
S
M
Q
Site 7
S52
K
Y
S
E
F
L
P
S
M
Q
S
A
Q
G
L
Site 8
S55
E
F
L
P
S
M
Q
S
A
Q
G
L
I
T
Q
Site 9
T61
Q
S
A
Q
G
L
I
T
Q
V
D
K
L
S
E
Site 10
S67
I
T
Q
V
D
K
L
S
E
D
I
D
L
L
K
Site 11
S75
E
D
I
D
L
L
K
S
R
I
E
S
E
V
R
Site 12
S79
L
L
K
S
R
I
E
S
E
V
R
R
D
L
H
Site 13
S88
V
R
R
D
L
H
V
S
T
G
E
F
T
D
L
Site 14
S103
K
Q
Q
L
E
R
D
S
V
V
L
S
L
L
K
Site 15
S107
E
R
D
S
V
V
L
S
L
L
K
Q
L
Q
E
Site 16
S116
L
K
Q
L
Q
E
F
S
T
A
I
E
E
Y
N
Site 17
Y131
C
A
L
T
E
K
K
Y
V
T
G
A
Q
R
L
Site 18
T133
L
T
E
K
K
Y
V
T
G
A
Q
R
L
E
E
Site 19
S150
K
C
L
K
L
L
K
S
R
K
C
F
D
L
K
Site 20
T167
K
S
L
S
M
E
L
T
I
Q
K
Q
N
I
L
Site 21
Y175
I
Q
K
Q
N
I
L
Y
H
L
G
E
E
W
Q
Site 22
S192
I
V
W
K
F
P
P
S
K
D
T
S
S
L
E
Site 23
T195
K
F
P
P
S
K
D
T
S
S
L
E
S
Y
L
Site 24
S196
F
P
P
S
K
D
T
S
S
L
E
S
Y
L
Q
Site 25
S197
P
P
S
K
D
T
S
S
L
E
S
Y
L
Q
T
Site 26
S200
K
D
T
S
S
L
E
S
Y
L
Q
T
E
L
H
Site 27
Y201
D
T
S
S
L
E
S
Y
L
Q
T
E
L
H
L
Site 28
T204
S
L
E
S
Y
L
Q
T
E
L
H
L
Y
T
E
Site 29
Y209
L
Q
T
E
L
H
L
Y
T
E
Q
S
H
K
E
Site 30
S213
L
H
L
Y
T
E
Q
S
H
K
E
E
K
T
P
Site 31
T219
Q
S
H
K
E
E
K
T
P
M
P
P
I
S
S
Site 32
S239
S
V
L
G
E
L
H
S
K
L
K
S
F
G
Q
Site 33
S243
E
L
H
S
K
L
K
S
F
G
Q
M
L
L
K
Site 34
T282
I
R
F
E
S
I
M
T
N
L
E
Y
P
S
P
Site 35
Y286
S
I
M
T
N
L
E
Y
P
S
P
S
E
V
F
Site 36
S288
M
T
N
L
E
Y
P
S
P
S
E
V
F
T
K
Site 37
S290
N
L
E
Y
P
S
P
S
E
V
F
T
K
I
R
Site 38
T321
T
D
L
E
N
E
K
T
S
T
V
P
L
A
E
Site 39
T323
L
E
N
E
K
T
S
T
V
P
L
A
E
M
L
Site 40
Y349
L
I
K
N
C
L
V
Y
S
I
P
T
N
S
S
Site 41
S350
I
K
N
C
L
V
Y
S
I
P
T
N
S
S
K
Site 42
Y361
N
S
S
K
L
Q
Q
Y
E
E
I
I
Q
S
T
Site 43
S367
Q
Y
E
E
I
I
Q
S
T
E
E
F
E
N
A
Site 44
T386
R
F
L
K
G
D
T
T
D
L
L
K
Y
A
R
Site 45
Y391
D
T
T
D
L
L
K
Y
A
R
N
I
N
S
H
Site 46
S417
A
A
R
N
L
M
T
S
E
I
H
N
T
V
K
Site 47
T422
M
T
S
E
I
H
N
T
V
K
I
I
P
D
S
Site 48
T438
I
N
V
P
E
L
P
T
P
D
E
D
N
K
L
Site 49
Y455
Q
K
V
S
N
T
Q
Y
H
E
V
M
N
L
E
Site 50
T466
M
N
L
E
P
E
N
T
L
D
Q
H
S
F
S
Site 51
S471
E
N
T
L
D
Q
H
S
F
S
L
P
T
C
R
Site 52
S473
T
L
D
Q
H
S
F
S
L
P
T
C
R
I
S
Site 53
T476
Q
H
S
F
S
L
P
T
C
R
I
S
E
S
V
Site 54
S480
S
L
P
T
C
R
I
S
E
S
V
K
K
L
M
Site 55
S482
P
T
C
R
I
S
E
S
V
K
K
L
M
E
L
Site 56
Y491
K
K
L
M
E
L
A
Y
Q
T
L
L
E
A
T
Site 57
S500
T
L
L
E
A
T
T
S
S
D
Q
C
A
V
Q
Site 58
Y526
F
H
D
V
V
P
T
Y
H
K
E
N
L
Q
K
Site 59
T586
P
G
F
R
R
L
G
T
E
C
F
L
A
Q
M
Site 60
S605
G
E
L
L
E
R
L
S
S
A
R
N
F
S
N
Site 61
S606
E
L
L
E
R
L
S
S
A
R
N
F
S
N
M
Site 62
S611
L
S
S
A
R
N
F
S
N
M
D
D
E
E
N
Site 63
S620
M
D
D
E
E
N
Y
S
A
A
S
K
A
V
R
Site 64
S662
T
L
L
N
T
A
I
S
E
V
I
G
K
I
T
Site 65
T676
T
A
L
E
D
I
S
T
E
D
G
D
R
L
Y
Site 66
Y683
T
E
D
G
D
R
L
Y
S
L
C
K
T
V
M
Site 67
S684
E
D
G
D
R
L
Y
S
L
C
K
T
V
M
D
Site 68
T688
R
L
Y
S
L
C
K
T
V
M
D
E
G
P
Q
Site 69
S701
P
Q
V
F
A
P
L
S
E
E
S
K
N
K
K
Site 70
Y709
E
E
S
K
N
K
K
Y
Q
E
E
V
P
V
Y
Site 71
Y716
Y
Q
E
E
V
P
V
Y
V
P
K
W
M
P
F
Site 72
S755
L
A
A
A
F
S
S
S
E
V
K
A
L
I
R
Site 73
T768
I
R
A
L
F
Q
N
T
E
R
R
A
A
A
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation