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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SPINT1
Full Name:
Kunitz-type protease inhibitor 1
Alias:
HAI; HAI1; HAI-1; Hepatocyte growth factor activator inhibitor type 1; Kunitz-type protease inhibitor 1; MANSC2; Serine peptidase inhibitor, Kunitz type 1; SPIT1
Type:
Mass (Da):
58400
Number AA:
UniProt ID:
O43278
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005576
GO:0005624
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0004867
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S78
N
G
A
T
F
L
E
S
P
T
V
R
R
G
W
Site 2
T80
A
T
F
L
E
S
P
T
V
R
R
G
W
D
C
Site 3
Y140
P
R
E
G
F
I
N
Y
L
T
R
E
V
Y
R
Site 4
T142
E
G
F
I
N
Y
L
T
R
E
V
Y
R
S
Y
Site 5
Y146
N
Y
L
T
R
E
V
Y
R
S
Y
R
Q
L
R
Site 6
S148
L
T
R
E
V
Y
R
S
Y
R
Q
L
R
T
Q
Site 7
Y149
T
R
E
V
Y
R
S
Y
R
Q
L
R
T
Q
G
Site 8
T154
R
S
Y
R
Q
L
R
T
Q
G
F
G
G
S
G
Site 9
S160
R
T
Q
G
F
G
G
S
G
I
P
K
A
W
A
Site 10
T196
W
R
L
L
R
G
D
T
D
V
R
V
E
R
K
Site 11
T223
G
T
Y
L
F
Q
L
T
V
T
S
S
D
H
P
Site 12
S227
F
Q
L
T
V
T
S
S
D
H
P
E
D
T
A
Site 13
T233
S
S
D
H
P
E
D
T
A
N
V
T
V
T
V
Site 14
T237
P
E
D
T
A
N
V
T
V
T
V
L
S
T
K
Site 15
T246
T
V
L
S
T
K
Q
T
E
D
Y
C
L
A
S
Site 16
Y249
S
T
K
Q
T
E
D
Y
C
L
A
S
N
K
V
Site 17
Y267
R
G
S
F
P
R
W
Y
Y
D
P
T
E
Q
I
Site 18
S277
P
T
E
Q
I
C
K
S
F
V
Y
G
G
C
L
Site 19
Y290
C
L
G
N
K
N
N
Y
L
R
E
E
E
C
I
Site 20
S311
Q
G
G
P
L
R
G
S
S
G
A
Q
A
T
F
Site 21
S312
G
G
P
L
R
G
S
S
G
A
Q
A
T
F
P
Site 22
T317
G
S
S
G
A
Q
A
T
F
P
Q
G
P
S
M
Site 23
S332
E
R
R
H
P
V
C
S
G
T
C
Q
P
T
Q
Site 24
T357
S
F
L
E
C
D
D
T
P
N
C
P
D
A
S
Site 25
S364
T
P
N
C
P
D
A
S
D
E
A
A
C
E
K
Site 26
Y372
D
E
A
A
C
E
K
Y
T
S
G
F
D
E
L
Site 27
S374
A
A
C
E
K
Y
T
S
G
F
D
E
L
Q
R
Site 28
T397
H
C
V
D
L
P
D
T
G
L
C
K
E
S
I
Site 29
Y408
K
E
S
I
P
R
W
Y
Y
N
P
F
S
E
H
Site 30
Y421
E
H
C
A
R
F
T
Y
G
G
C
Y
G
N
K
Site 31
S440
E
E
Q
Q
C
L
E
S
C
R
G
I
S
K
K
Site 32
S445
L
E
S
C
R
G
I
S
K
K
D
V
F
G
L
Site 33
S460
R
R
E
I
P
I
P
S
T
G
S
V
E
M
A
Site 34
T505
H
H
H
H
P
P
P
T
P
A
S
S
T
V
S
Site 35
S508
H
P
P
P
T
P
A
S
S
T
V
S
T
T
E
Site 36
S509
P
P
P
T
P
A
S
S
T
V
S
T
T
E
D
Site 37
T510
P
P
T
P
A
S
S
T
V
S
T
T
E
D
T
Site 38
S512
T
P
A
S
S
T
V
S
T
T
E
D
T
E
H
Site 39
T513
P
A
S
S
T
V
S
T
T
E
D
T
E
H
L
Site 40
T514
A
S
S
T
V
S
T
T
E
D
T
E
H
L
V
Site 41
Y522
E
D
T
E
H
L
V
Y
N
H
T
T
R
P
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation