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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MAP3K13
Full Name:
Mitogen-activated protein kinase kinase kinase 13
Alias:
Leucine zipper-bearing kinase;Mixed lineage kinase
Type:
Mass (Da):
108296
Number AA:
966
UniProt ID:
O43283
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
A
N
F
Q
E
H
L
S
C
S
S
S
P
H
L
Site 2
S11
F
Q
E
H
L
S
C
S
S
S
P
H
L
P
F
Site 3
S13
E
H
L
S
C
S
S
S
P
H
L
P
F
S
E
Site 4
S19
S
S
P
H
L
P
F
S
E
S
K
T
F
N
G
Site 5
S21
P
H
L
P
F
S
E
S
K
T
F
N
G
L
Q
Site 6
T23
L
P
F
S
E
S
K
T
F
N
G
L
Q
D
E
Site 7
T32
N
G
L
Q
D
E
L
T
A
M
G
N
H
P
S
Site 8
S39
T
A
M
G
N
H
P
S
P
K
L
L
E
D
Q
Site 9
S59
V
R
T
E
L
I
E
S
V
H
S
P
V
T
T
Site 10
S71
V
T
T
T
V
L
T
S
V
S
E
D
S
R
D
Site 11
S73
T
T
V
L
T
S
V
S
E
D
S
R
D
Q
F
Site 12
S76
L
T
S
V
S
E
D
S
R
D
Q
F
E
N
S
Site 13
S93
Q
L
R
E
H
D
E
S
E
T
A
V
S
Q
G
Site 14
S98
D
E
S
E
T
A
V
S
Q
G
N
S
N
T
V
Site 15
S102
T
A
V
S
Q
G
N
S
N
T
V
D
G
E
S
Site 16
T104
V
S
Q
G
N
S
N
T
V
D
G
E
S
T
S
Site 17
T113
D
G
E
S
T
S
G
T
E
D
I
K
I
Q
F
Site 18
S121
E
D
I
K
I
Q
F
S
R
S
G
S
G
S
G
Site 19
S123
I
K
I
Q
F
S
R
S
G
S
G
S
G
G
F
Site 20
S125
I
Q
F
S
R
S
G
S
G
S
G
G
F
L
E
Site 21
S127
F
S
R
S
G
S
G
S
G
G
F
L
E
G
L
Site 22
S150
N
I
I
G
K
A
Y
S
T
D
Y
K
L
Q
Q
Site 23
Y153
G
K
A
Y
S
T
D
Y
K
L
Q
Q
Q
D
T
Site 24
T160
Y
K
L
Q
Q
Q
D
T
W
E
V
P
F
E
E
Site 25
T203
K
V
R
E
Q
N
E
T
D
I
K
H
L
R
K
Site 26
Y242
Y
C
A
H
G
Q
L
Y
E
V
L
R
A
G
R
Site 27
T252
L
R
A
G
R
K
I
T
P
R
L
L
V
D
W
Site 28
S282
I
I
H
R
D
L
K
S
P
N
V
L
V
T
H
Site 29
T288
K
S
P
N
V
L
V
T
H
T
D
A
V
K
I
Site 30
T290
P
N
V
L
V
T
H
T
D
A
V
K
I
S
D
Site 31
T300
V
K
I
S
D
F
G
T
S
K
E
L
S
D
K
Site 32
S301
K
I
S
D
F
G
T
S
K
E
L
S
D
K
S
Site 33
S305
F
G
T
S
K
E
L
S
D
K
S
T
K
M
S
Site 34
S308
S
K
E
L
S
D
K
S
T
K
M
S
F
A
G
Site 35
T309
K
E
L
S
D
K
S
T
K
M
S
F
A
G
T
Site 36
S312
S
D
K
S
T
K
M
S
F
A
G
T
V
A
W
Site 37
S331
V
I
R
N
E
P
V
S
E
K
V
D
I
W
S
Site 38
S359
P
Y
K
D
V
D
S
S
A
I
I
W
G
V
G
Site 39
S376
S
L
H
L
P
V
P
S
T
C
P
D
G
F
K
Site 40
S399
S
K
P
R
N
R
P
S
F
R
Q
T
L
M
H
Site 41
T403
N
R
P
S
F
R
Q
T
L
M
H
L
D
I
A
Site 42
T417
A
S
A
D
V
L
A
T
P
Q
E
T
Y
F
K
Site 43
Y422
L
A
T
P
Q
E
T
Y
F
K
S
Q
A
E
W
Site 44
S425
P
Q
E
T
Y
F
K
S
Q
A
E
W
R
E
E
Site 45
Y472
A
L
D
I
R
E
H
Y
E
R
K
L
E
R
A
Site 46
Y483
L
E
R
A
N
N
L
Y
M
E
L
S
A
I
M
Site 47
Y511
E
Q
A
V
E
K
K
Y
P
G
T
Y
K
R
H
Site 48
T514
V
E
K
K
Y
P
G
T
Y
K
R
H
P
V
R
Site 49
S542
R
K
G
V
P
H
K
S
G
M
Q
T
K
R
P
Site 50
T546
P
H
K
S
G
M
Q
T
K
R
P
D
L
L
R
Site 51
S554
K
R
P
D
L
L
R
S
E
G
I
P
T
T
E
Site 52
T559
L
R
S
E
G
I
P
T
T
E
V
A
P
T
A
Site 53
T560
R
S
E
G
I
P
T
T
E
V
A
P
T
A
S
Site 54
T565
P
T
T
E
V
A
P
T
A
S
P
L
S
G
S
Site 55
S567
T
E
V
A
P
T
A
S
P
L
S
G
S
P
K
Site 56
S570
A
P
T
A
S
P
L
S
G
S
P
K
M
S
T
Site 57
S572
T
A
S
P
L
S
G
S
P
K
M
S
T
S
S
Site 58
S576
L
S
G
S
P
K
M
S
T
S
S
S
K
S
R
Site 59
T577
S
G
S
P
K
M
S
T
S
S
S
K
S
R
Y
Site 60
S578
G
S
P
K
M
S
T
S
S
S
K
S
R
Y
R
Site 61
S579
S
P
K
M
S
T
S
S
S
K
S
R
Y
R
S
Site 62
S580
P
K
M
S
T
S
S
S
K
S
R
Y
R
S
K
Site 63
S582
M
S
T
S
S
S
K
S
R
Y
R
S
K
P
R
Site 64
Y584
T
S
S
S
K
S
R
Y
R
S
K
P
R
H
R
Site 65
S586
S
S
K
S
R
Y
R
S
K
P
R
H
R
R
G
Site 66
S595
P
R
H
R
R
G
N
S
R
G
S
H
S
D
F
Site 67
S598
R
R
G
N
S
R
G
S
H
S
D
F
A
A
I
Site 68
S615
N
Q
P
A
Q
E
N
S
P
H
P
T
Y
L
H
Site 69
T619
Q
E
N
S
P
H
P
T
Y
L
H
Q
A
Q
S
Site 70
Y620
E
N
S
P
H
P
T
Y
L
H
Q
A
Q
S
Q
Site 71
S626
T
Y
L
H
Q
A
Q
S
Q
Y
P
S
L
H
H
Site 72
Y628
L
H
Q
A
Q
S
Q
Y
P
S
L
H
H
H
N
Site 73
S630
Q
A
Q
S
Q
Y
P
S
L
H
H
H
N
S
L
Site 74
Y641
H
N
S
L
Q
Q
Q
Y
Q
Q
P
P
P
A
M
Site 75
S649
Q
Q
P
P
P
A
M
S
Q
S
H
H
P
R
L
Site 76
S651
P
P
P
A
M
S
Q
S
H
H
P
R
L
N
M
Site 77
S681
G
P
A
A
A
L
R
S
P
L
S
N
H
A
Q
Site 78
S684
A
A
L
R
S
P
L
S
N
H
A
Q
R
Q
L
Site 79
S694
A
Q
R
Q
L
P
G
S
S
P
D
L
I
S
T
Site 80
S695
Q
R
Q
L
P
G
S
S
P
D
L
I
S
T
A
Site 81
S711
A
A
D
C
W
R
S
S
E
P
D
K
G
Q
A
Site 82
S742
C
R
P
E
Q
Y
G
S
L
D
I
P
S
A
E
Site 83
S747
Y
G
S
L
D
I
P
S
A
E
P
V
G
R
S
Site 84
S754
S
A
E
P
V
G
R
S
P
D
L
S
K
S
P
Site 85
S758
V
G
R
S
P
D
L
S
K
S
P
A
H
N
P
Site 86
S760
R
S
P
D
L
S
K
S
P
A
H
N
P
L
L
Site 87
S772
P
L
L
E
N
A
Q
S
S
E
K
T
E
E
N
Site 88
T776
N
A
Q
S
S
E
K
T
E
E
N
E
F
S
G
Site 89
S782
K
T
E
E
N
E
F
S
G
C
R
S
E
S
S
Site 90
S786
N
E
F
S
G
C
R
S
E
S
S
L
G
T
S
Site 91
S788
F
S
G
C
R
S
E
S
S
L
G
T
S
H
L
Site 92
S789
S
G
C
R
S
E
S
S
L
G
T
S
H
L
G
Site 93
T792
R
S
E
S
S
L
G
T
S
H
L
G
T
P
P
Site 94
S793
S
E
S
S
L
G
T
S
H
L
G
T
P
P
A
Site 95
T797
L
G
T
S
H
L
G
T
P
P
A
L
P
R
K
Site 96
T805
P
P
A
L
P
R
K
T
R
P
L
Q
K
S
G
Site 97
S811
K
T
R
P
L
Q
K
S
G
D
D
S
S
E
E
Site 98
S815
L
Q
K
S
G
D
D
S
S
E
E
E
E
G
E
Site 99
S816
Q
K
S
G
D
D
S
S
E
E
E
E
G
E
V
Site 100
S825
E
E
E
G
E
V
D
S
E
V
E
F
P
R
R
Site 101
S840
Q
R
P
H
R
C
I
S
S
C
Q
S
Y
S
T
Site 102
S844
R
C
I
S
S
C
Q
S
Y
S
T
F
S
S
E
Site 103
Y845
C
I
S
S
C
Q
S
Y
S
T
F
S
S
E
N
Site 104
S846
I
S
S
C
Q
S
Y
S
T
F
S
S
E
N
F
Site 105
T847
S
S
C
Q
S
Y
S
T
F
S
S
E
N
F
S
Site 106
S849
C
Q
S
Y
S
T
F
S
S
E
N
F
S
V
S
Site 107
S850
Q
S
Y
S
T
F
S
S
E
N
F
S
V
S
D
Site 108
S854
T
F
S
S
E
N
F
S
V
S
D
G
E
E
G
Site 109
S856
S
S
E
N
F
S
V
S
D
G
E
E
G
N
T
Site 110
T863
S
D
G
E
E
G
N
T
S
D
H
S
N
S
P
Site 111
S864
D
G
E
E
G
N
T
S
D
H
S
N
S
P
D
Site 112
S867
E
G
N
T
S
D
H
S
N
S
P
D
E
L
A
Site 113
S869
N
T
S
D
H
S
N
S
P
D
E
L
A
D
K
Site 114
S890
E
K
L
D
D
L
L
S
Q
T
P
E
I
P
I
Site 115
S900
P
E
I
P
I
D
I
S
S
H
S
D
G
L
S
Site 116
S901
E
I
P
I
D
I
S
S
H
S
D
G
L
S
D
Site 117
S903
P
I
D
I
S
S
H
S
D
G
L
S
D
K
E
Site 118
S907
S
S
H
S
D
G
L
S
D
K
E
C
A
V
R
Site 119
T918
C
A
V
R
R
V
K
T
Q
M
S
L
G
K
L
Site 120
Y932
L
C
V
E
E
R
G
Y
E
N
P
M
Q
F
E
Site 121
S941
N
P
M
Q
F
E
E
S
D
C
D
S
S
D
G
Site 122
S945
F
E
E
S
D
C
D
S
S
D
G
E
C
S
D
Site 123
S946
E
E
S
D
C
D
S
S
D
G
E
C
S
D
A
Site 124
S951
D
S
S
D
G
E
C
S
D
A
T
V
R
T
N
Site 125
T954
D
G
E
C
S
D
A
T
V
R
T
N
K
H
Y
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation