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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ARHGAP14
Full Name:
SLIT-ROBO Rho GTPase-activating protein 3
Alias:
KIAA0411; MEGAP; Mental disorder-associated GAP; Rho GTPase-activating 14; Rho GTPase-activating protein 14; SLIT-ROBO rho GTPase activating 2; SLIT-ROBO rho GTPase activating 3; SLIT-ROBO Rho GTPase activating protein 3; SLIT-ROBO Rho GTPase-activating 3; SRGAP2; SrGAP2; SRGP2; WAVE-associated Rac GTPase activating; WAVE-associated Rac GTPase-activating; WAVE-associated Rac GTPase-activating protein; WRP
Type:
GTPase activating protein, Rac/Rho
Mass (Da):
124504
Number AA:
1099
UniProt ID:
O43295
International Prot ID:
IPI00218087
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0005096
PhosphoSite+
KinaseNET
Biological Process:
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y17
D
K
E
I
I
A
E
Y
E
A
Q
I
K
E
I
Site 2
S39
F
K
C
L
E
Q
Q
S
E
S
R
L
Q
L
L
Site 3
Y63
K
A
E
I
E
L
E
Y
S
R
S
L
E
K
L
Site 4
S64
A
E
I
E
L
E
Y
S
R
S
L
E
K
L
A
Site 5
S66
I
E
L
E
Y
S
R
S
L
E
K
L
A
E
R
Site 6
S75
E
K
L
A
E
R
F
S
S
K
I
R
S
S
R
Site 7
S76
K
L
A
E
R
F
S
S
K
I
R
S
S
R
E
Site 8
S80
R
F
S
S
K
I
R
S
S
R
E
H
Q
F
K
Site 9
S81
F
S
S
K
I
R
S
S
R
E
H
Q
F
K
K
Site 10
Y91
H
Q
F
K
K
D
Q
Y
L
L
S
P
V
N
C
Site 11
S110
L
H
Q
T
R
R
E
S
R
D
H
A
T
L
N
Site 12
T115
R
E
S
R
D
H
A
T
L
N
D
I
F
M
N
Site 13
S142
V
I
R
L
F
K
K
S
K
E
I
G
L
Q
M
Site 14
T157
H
E
E
L
L
K
V
T
N
E
L
Y
T
V
M
Site 15
Y161
L
K
V
T
N
E
L
Y
T
V
M
K
T
Y
H
Site 16
T162
K
V
T
N
E
L
Y
T
V
M
K
T
Y
H
M
Site 17
Y170
V
M
K
T
Y
H
M
Y
H
A
E
S
I
S
A
Site 18
S174
Y
H
M
Y
H
A
E
S
I
S
A
E
S
K
L
Site 19
S195
E
E
K
Q
F
N
K
S
G
D
L
S
M
N
L
Site 20
S199
F
N
K
S
G
D
L
S
M
N
L
L
R
H
E
Site 21
S213
E
D
R
P
Q
R
R
S
S
V
K
K
I
E
K
Site 22
S214
D
R
P
Q
R
R
S
S
V
K
K
I
E
K
M
Site 23
Y229
K
E
K
R
Q
A
K
Y
S
E
N
K
L
K
C
Site 24
S230
E
K
R
Q
A
K
Y
S
E
N
K
L
K
C
T
Site 25
Y243
C
T
K
A
R
N
D
Y
L
L
N
L
A
A
T
Site 26
Y257
T
N
A
A
I
S
K
Y
Y
I
H
D
V
S
D
Site 27
S276
C
D
L
G
F
H
A
S
L
A
R
T
F
R
T
Site 28
T280
F
H
A
S
L
A
R
T
F
R
T
Y
L
S
A
Site 29
Y284
L
A
R
T
F
R
T
Y
L
S
A
E
Y
N
L
Site 30
S286
R
T
F
R
T
Y
L
S
A
E
Y
N
L
E
T
Site 31
T293
S
A
E
Y
N
L
E
T
S
R
H
E
G
L
D
Site 32
S311
N
A
V
D
N
L
D
S
R
S
D
K
H
T
V
Site 33
S313
V
D
N
L
D
S
R
S
D
K
H
T
V
M
D
Site 34
T317
D
S
R
S
D
K
H
T
V
M
D
M
C
N
Q
Site 35
Y359
Q
T
E
L
L
M
R
Y
H
Q
L
Q
S
R
L
Site 36
T368
Q
L
Q
S
R
L
A
T
L
K
I
E
N
E
E
Site 37
T379
E
N
E
E
V
R
K
T
L
D
A
T
M
Q
T
Site 38
T392
Q
T
L
Q
D
M
L
T
V
E
D
F
D
V
S
Site 39
S399
T
V
E
D
F
D
V
S
D
A
F
Q
H
S
R
Site 40
S405
V
S
D
A
F
Q
H
S
R
S
T
E
S
V
K
Site 41
S407
D
A
F
Q
H
S
R
S
T
E
S
V
K
S
A
Site 42
T408
A
F
Q
H
S
R
S
T
E
S
V
K
S
A
A
Site 43
S410
Q
H
S
R
S
T
E
S
V
K
S
A
A
S
E
Site 44
S413
R
S
T
E
S
V
K
S
A
A
S
E
T
Y
M
Site 45
S416
E
S
V
K
S
A
A
S
E
T
Y
M
S
K
I
Site 46
Y439
Q
Q
E
T
E
M
F
Y
F
T
K
F
K
E
Y
Site 47
Y446
Y
F
T
K
F
K
E
Y
V
N
G
S
N
L
I
Site 48
T454
V
N
G
S
N
L
I
T
K
L
Q
A
K
H
D
Site 49
T477
G
E
R
A
E
C
G
T
T
R
P
P
C
L
P
Site 50
T478
E
R
A
E
C
G
T
T
R
P
P
C
L
P
P
Site 51
S497
M
R
R
P
R
P
L
S
V
Y
S
H
K
L
F
Site 52
Y499
R
P
R
P
L
S
V
Y
S
H
K
L
F
N
G
Site 53
S500
P
R
P
L
S
V
Y
S
H
K
L
F
N
G
S
Site 54
S507
S
H
K
L
F
N
G
S
M
E
A
F
I
K
D
Site 55
S556
E
V
N
D
I
K
N
S
F
E
R
G
E
D
P
Site 56
S575
Q
N
E
R
D
I
N
S
V
A
G
V
L
K
L
Site 57
S602
E
R
F
Q
D
L
I
S
T
I
K
L
E
N
P
Site 58
S645
L
N
H
L
S
Q
Y
S
D
E
N
M
M
D
P
Site 59
Y653
D
E
N
M
M
D
P
Y
N
L
A
I
C
F
G
Site 60
S674
P
D
G
Q
D
P
V
S
C
Q
A
H
I
N
E
Site 61
S696
H
H
E
A
I
F
P
S
P
R
E
L
E
G
P
Site 62
Y705
R
E
L
E
G
P
V
Y
E
K
C
M
A
G
G
Site 63
S718
G
G
E
E
Y
C
D
S
P
H
S
E
P
G
A
Site 64
S721
E
Y
C
D
S
P
H
S
E
P
G
A
I
D
E
Site 65
T735
E
V
D
H
D
N
G
T
E
P
H
T
S
D
E
Site 66
S740
N
G
T
E
P
H
T
S
D
E
E
V
E
Q
I
Site 67
Y755
E
A
I
A
K
F
D
Y
M
G
R
S
P
R
E
Site 68
S759
K
F
D
Y
M
G
R
S
P
R
E
L
S
F
K
Site 69
S764
G
R
S
P
R
E
L
S
F
K
K
G
A
S
L
Site 70
Y774
K
G
A
S
L
L
L
Y
H
R
A
S
E
D
W
Site 71
S778
L
L
L
Y
H
R
A
S
E
D
W
W
E
G
R
Site 72
Y797
D
G
L
I
P
H
Q
Y
I
V
V
Q
D
M
D
Site 73
S808
Q
D
M
D
D
A
F
S
D
S
L
S
Q
K
A
Site 74
S810
M
D
D
A
F
S
D
S
L
S
Q
K
A
D
S
Site 75
S812
D
A
F
S
D
S
L
S
Q
K
A
D
S
E
A
Site 76
S817
S
L
S
Q
K
A
D
S
E
A
S
S
G
P
L
Site 77
S821
K
A
D
S
E
A
S
S
G
P
L
L
D
D
K
Site 78
S830
P
L
L
D
D
K
A
S
S
K
N
D
L
Q
S
Site 79
S831
L
L
D
D
K
A
S
S
K
N
D
L
Q
S
P
Site 80
S837
S
S
K
N
D
L
Q
S
P
T
E
H
I
S
D
Site 81
T839
K
N
D
L
Q
S
P
T
E
H
I
S
D
Y
G
Site 82
S843
Q
S
P
T
E
H
I
S
D
Y
G
F
G
G
V
Site 83
Y845
P
T
E
H
I
S
D
Y
G
F
G
G
V
M
G
Site 84
S858
M
G
R
V
R
L
R
S
D
G
A
A
I
P
R
Site 85
S868
A
A
I
P
R
R
R
S
G
G
D
T
H
S
P
Site 86
T872
R
R
R
S
G
G
D
T
H
S
P
P
R
G
L
Site 87
S874
R
S
G
G
D
T
H
S
P
P
R
G
L
G
P
Site 88
S882
P
P
R
G
L
G
P
S
I
D
T
P
P
R
A
Site 89
T885
G
L
G
P
S
I
D
T
P
P
R
A
A
A
C
Site 90
S894
P
R
A
A
A
C
P
S
S
P
H
K
I
P
L
Site 91
S895
R
A
A
A
C
P
S
S
P
H
K
I
P
L
T
Site 92
T902
S
P
H
K
I
P
L
T
R
G
R
I
E
S
P
Site 93
S908
L
T
R
G
R
I
E
S
P
E
K
R
R
M
A
Site 94
T916
P
E
K
R
R
M
A
T
F
G
S
A
G
S
I
Site 95
S919
R
R
M
A
T
F
G
S
A
G
S
I
N
Y
P
Site 96
Y925
G
S
A
G
S
I
N
Y
P
D
K
K
A
L
S
Site 97
S932
Y
P
D
K
K
A
L
S
E
G
H
S
M
R
S
Site 98
S936
K
A
L
S
E
G
H
S
M
R
S
T
C
G
S
Site 99
S939
S
E
G
H
S
M
R
S
T
C
G
S
T
R
H
Site 100
T940
E
G
H
S
M
R
S
T
C
G
S
T
R
H
S
Site 101
S943
S
M
R
S
T
C
G
S
T
R
H
S
S
L
G
Site 102
T944
M
R
S
T
C
G
S
T
R
H
S
S
L
G
D
Site 103
S947
T
C
G
S
T
R
H
S
S
L
G
D
H
K
S
Site 104
S948
C
G
S
T
R
H
S
S
L
G
D
H
K
S
L
Site 105
S954
S
S
L
G
D
H
K
S
L
E
A
E
A
L
A
Site 106
T967
L
A
E
D
I
E
K
T
M
S
T
A
L
H
E
Site 107
S969
E
D
I
E
K
T
M
S
T
A
L
H
E
L
R
Site 108
T970
D
I
E
K
T
M
S
T
A
L
H
E
L
R
E
Site 109
T983
R
E
L
E
R
Q
N
T
V
K
Q
A
P
D
V
Site 110
T994
A
P
D
V
V
L
D
T
L
E
P
L
K
N
P
Site 111
S1006
K
N
P
P
G
P
V
S
S
E
P
A
S
P
L
Site 112
S1007
N
P
P
G
P
V
S
S
E
P
A
S
P
L
H
Site 113
T1015
E
P
A
S
P
L
H
T
I
V
I
R
D
P
D
Site 114
S1028
P
D
A
A
M
R
R
S
S
S
S
S
T
E
M
Site 115
S1029
D
A
A
M
R
R
S
S
S
S
S
T
E
M
M
Site 116
S1030
A
A
M
R
R
S
S
S
S
S
T
E
M
M
T
Site 117
S1031
A
M
R
R
S
S
S
S
S
T
E
M
M
T
T
Site 118
S1032
M
R
R
S
S
S
S
S
T
E
M
M
T
T
F
Site 119
T1033
R
R
S
S
S
S
S
T
E
M
M
T
T
F
K
Site 120
T1038
S
S
T
E
M
M
T
T
F
K
P
A
L
S
A
Site 121
S1068
R
P
V
V
Q
H
R
S
S
S
S
S
S
S
G
Site 122
S1069
P
V
V
Q
H
R
S
S
S
S
S
S
S
G
V
Site 123
S1070
V
V
Q
H
R
S
S
S
S
S
S
S
G
V
G
Site 124
S1071
V
Q
H
R
S
S
S
S
S
S
S
G
V
G
S
Site 125
S1072
Q
H
R
S
S
S
S
S
S
S
G
V
G
S
P
Site 126
S1073
H
R
S
S
S
S
S
S
S
G
V
G
S
P
A
Site 127
S1074
R
S
S
S
S
S
S
S
G
V
G
S
P
A
V
Site 128
S1078
S
S
S
S
G
V
G
S
P
A
V
T
P
T
E
Site 129
T1082
G
V
G
S
P
A
V
T
P
T
E
K
M
F
P
Site 130
T1084
G
S
P
A
V
T
P
T
E
K
M
F
P
N
S
Site 131
S1091
T
E
K
M
F
P
N
S
S
A
D
K
S
G
T
Site 132
S1092
E
K
M
F
P
N
S
S
A
D
K
S
G
T
M
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation