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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HSPA12A
Full Name:
Heat shock 70 kDa protein 12A
Alias:
FLJ13874; Heat shock 12A; Heat shock 70 kDa 12A; Heat shock 70kD 12A; Heat shock 70kDa 12A; Heat shock 70kDa protein 12A; HS12A; KIAA0417
Type:
Unknown function
Mass (Da):
74978
Number AA:
675
UniProt ID:
O43301
International Prot ID:
IPI00011932
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005524
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
A
D
K
E
A
G
G
S
D
G
P
R
E
T
A
Site 2
T15
G
S
D
G
P
R
E
T
A
P
T
S
A
Y
S
Site 3
T18
G
P
R
E
T
A
P
T
S
A
Y
S
S
P
A
Site 4
S19
P
R
E
T
A
P
T
S
A
Y
S
S
P
A
R
Site 5
Y21
E
T
A
P
T
S
A
Y
S
S
P
A
R
S
L
Site 6
S22
T
A
P
T
S
A
Y
S
S
P
A
R
S
L
G
Site 7
S23
A
P
T
S
A
Y
S
S
P
A
R
S
L
G
D
Site 8
S27
A
Y
S
S
P
A
R
S
L
G
D
T
G
I
T
Site 9
T31
P
A
R
S
L
G
D
T
G
I
T
P
L
S
P
Site 10
T34
S
L
G
D
T
G
I
T
P
L
S
P
S
H
I
Site 11
S37
D
T
G
I
T
P
L
S
P
S
H
I
V
N
D
Site 12
T45
P
S
H
I
V
N
D
T
D
S
N
V
S
E
Q
Site 13
S47
H
I
V
N
D
T
D
S
N
V
S
E
Q
Q
S
Site 14
S68
V
D
F
G
T
T
S
S
G
Y
A
Y
S
F
T
Site 15
Y70
F
G
T
T
S
S
G
Y
A
Y
S
F
T
K
E
Site 16
Y72
T
T
S
S
G
Y
A
Y
S
F
T
K
E
P
E
Site 17
S73
T
S
S
G
Y
A
Y
S
F
T
K
E
P
E
C
Site 18
T75
S
G
Y
A
Y
S
F
T
K
E
P
E
C
I
H
Site 19
S95
E
G
G
D
P
G
V
S
N
Q
K
T
P
T
T
Site 20
T99
P
G
V
S
N
Q
K
T
P
T
T
I
L
L
T
Site 21
T102
S
N
Q
K
T
P
T
T
I
L
L
T
P
E
R
Site 22
T106
T
P
T
T
I
L
L
T
P
E
R
K
F
H
S
Site 23
S113
T
P
E
R
K
F
H
S
F
G
Y
A
A
R
D
Site 24
Y116
R
K
F
H
S
F
G
Y
A
A
R
D
F
Y
H
Site 25
Y122
G
Y
A
A
R
D
F
Y
H
D
L
D
P
N
E
Site 26
Y135
N
E
A
K
Q
W
L
Y
L
E
K
F
K
M
K
Site 27
T145
K
F
K
M
K
L
H
T
T
G
D
L
T
M
D
Site 28
T150
L
H
T
T
G
D
L
T
M
D
T
D
L
T
A
Site 29
T153
T
G
D
L
T
M
D
T
D
L
T
A
A
N
G
Site 30
T156
L
T
M
D
T
D
L
T
A
A
N
G
K
K
V
Site 31
S185
E
Q
A
L
K
E
L
S
D
Q
A
G
S
E
F
Site 32
S195
A
G
S
E
F
E
N
S
D
V
R
W
V
I
T
Site 33
S226
A
Y
Q
A
G
L
A
S
P
E
N
S
E
Q
L
Site 34
Y245
E
P
E
A
A
S
I
Y
C
R
K
L
R
L
H
Site 35
T271
N
G
Y
S
G
S
D
T
V
G
A
G
F
T
Q
Site 36
S289
H
I
R
R
N
R
Q
S
R
T
F
L
V
E
N
Site 37
T291
R
R
N
R
Q
S
R
T
F
L
V
E
N
V
I
Site 38
Y311
E
L
E
E
G
D
K
Y
V
V
V
D
S
G
G
Site 39
Y339
E
G
H
L
K
E
L
Y
K
A
T
G
G
P
Y
Site 40
T342
L
K
E
L
Y
K
A
T
G
G
P
Y
G
S
L
Site 41
S348
A
T
G
G
P
Y
G
S
L
G
V
D
Y
E
F
Site 42
Y353
Y
G
S
L
G
V
D
Y
E
F
E
K
L
L
Y
Site 43
Y360
Y
E
F
E
K
L
L
Y
K
I
F
G
E
D
F
Site 44
Y412
L
P
F
S
F
I
D
Y
Y
K
K
F
R
G
H
Site 45
Y413
P
F
S
F
I
D
Y
Y
K
K
F
R
G
H
S
Site 46
S420
Y
K
K
F
R
G
H
S
V
E
H
A
L
R
K
Site 47
S428
V
E
H
A
L
R
K
S
N
V
D
F
V
K
W
Site 48
S437
V
D
F
V
K
W
S
S
Q
G
M
L
R
M
S
Site 49
S444
S
Q
G
M
L
R
M
S
P
D
A
M
N
A
L
Site 50
S458
L
F
K
P
T
I
D
S
I
I
E
H
L
R
D
Site 51
T536
K
V
R
R
S
P
L
T
Y
G
V
G
V
L
N
Site 52
Y537
V
R
R
S
P
L
T
Y
G
V
G
V
L
N
R
Site 53
Y545
G
V
G
V
L
N
R
Y
V
E
G
K
H
P
P
Site 54
S573
D
V
F
D
K
F
I
S
A
D
Q
S
V
A
L
Site 55
S587
L
G
E
L
V
K
R
S
Y
T
P
A
K
P
S
Site 56
Y588
G
E
L
V
K
R
S
Y
T
P
A
K
P
S
Q
Site 57
T589
E
L
V
K
R
S
Y
T
P
A
K
P
S
Q
L
Site 58
S611
S
S
E
H
D
N
V
S
F
I
T
D
P
G
V
Site 59
T623
P
G
V
K
K
C
G
T
L
R
L
D
L
T
G
Site 60
T629
G
T
L
R
L
D
L
T
G
T
S
G
T
A
V
Site 61
T631
L
R
L
D
L
T
G
T
S
G
T
A
V
P
A
Site 62
S632
R
L
D
L
T
G
T
S
G
T
A
V
P
A
R
Site 63
T634
D
L
T
G
T
S
G
T
A
V
P
A
R
R
E
Site 64
T644
P
A
R
R
E
I
Q
T
L
M
Q
F
G
D
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation