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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ADCY6
Full Name:
Adenylate cyclase type 6
Alias:
AC6; Adenylate cyclase 6; Adenylate cyclase type VI; Adenylate cyclase, type VI; Adenylyl cyclase 6; ATP pyrophosphate-lyase; ATP pyrophosphate-lyase 6; Ca(2 )-inhibitable adenylyl cyclase; Ca(2+)-inhibitable adenylyl cyclase; CYA6; KIAA0422
Type:
EC 4.6.1.1; Adenylyl cyclase; Nucleotide Metabolism - purine; Lyase
Mass (Da):
130615
Number AA:
1168
UniProt ID:
O43306
International Prot ID:
IPI00011938
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004016
GO:0000287
PhosphoSite+
KinaseNET
Biological Process:
GO:0007189
GO:0034199
GO:0006171
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T17
P
K
V
D
E
R
K
T
A
W
G
E
R
N
G
Site 2
S28
E
R
N
G
Q
K
R
S
R
R
R
G
T
R
A
Site 3
T33
K
R
S
R
R
R
G
T
R
A
G
G
F
C
T
Site 4
T40
T
R
A
G
G
F
C
T
P
R
Y
M
S
C
L
Site 5
Y43
G
G
F
C
T
P
R
Y
M
S
C
L
R
D
A
Site 6
S45
F
C
T
P
R
Y
M
S
C
L
R
D
A
E
P
Site 7
S54
L
R
D
A
E
P
P
S
P
T
P
A
G
P
P
Site 8
T56
D
A
E
P
P
S
P
T
P
A
G
P
P
R
C
Site 9
T99
E
D
T
E
V
T
T
T
A
G
G
T
A
E
V
Site 10
S114
A
P
D
A
V
P
R
S
G
R
S
C
W
R
R
Site 11
S117
A
V
P
R
S
G
R
S
C
W
R
R
L
V
Q
Site 12
S128
R
L
V
Q
V
F
Q
S
K
Q
F
R
S
A
K
Site 13
Y140
S
A
K
L
E
R
L
Y
Q
R
Y
F
F
Q
M
Site 14
Y143
L
E
R
L
Y
Q
R
Y
F
F
Q
M
N
Q
S
Site 15
S236
A
A
D
P
R
S
P
S
A
G
L
W
C
P
V
Site 16
S313
T
H
Y
P
A
E
V
S
Q
R
Q
A
F
Q
E
Site 17
Y324
A
F
Q
E
T
R
G
Y
I
Q
A
R
L
H
L
Site 18
S344
Q
Q
E
R
L
L
L
S
V
L
P
Q
H
V
A
Site 19
S393
E
G
F
T
S
L
A
S
Q
C
T
A
Q
E
L
Site 20
S477
N
M
R
V
G
I
H
S
G
R
V
H
C
G
V
Site 21
T520
R
I
H
I
T
R
A
T
L
Q
Y
L
N
G
D
Site 22
Y523
I
T
R
A
T
L
Q
Y
L
N
G
D
Y
E
V
Site 23
Y528
L
Q
Y
L
N
G
D
Y
E
V
E
P
G
R
G
Site 24
Y541
R
G
G
E
R
N
A
Y
L
K
E
Q
H
I
E
Site 25
S556
T
F
L
I
L
G
A
S
Q
K
R
K
E
E
K
Site 26
T572
M
L
A
K
L
Q
R
T
R
A
N
S
M
E
G
Site 27
S576
L
Q
R
T
R
A
N
S
M
E
G
L
M
P
R
Site 28
S591
W
V
P
D
R
A
F
S
R
T
K
D
S
K
A
Site 29
T593
P
D
R
A
F
S
R
T
K
D
S
K
A
F
R
Site 30
S596
A
F
S
R
T
K
D
S
K
A
F
R
Q
M
G
Site 31
S607
R
Q
M
G
I
D
D
S
S
K
D
N
R
G
T
Site 32
S608
Q
M
G
I
D
D
S
S
K
D
N
R
G
T
Q
Site 33
T614
S
S
K
D
N
R
G
T
Q
D
A
L
N
P
E
Site 34
T651
H
V
R
R
F
L
L
T
F
Q
R
E
D
L
E
Site 35
Y661
R
E
D
L
E
K
K
Y
S
R
K
V
D
P
R
Site 36
S662
E
D
L
E
K
K
Y
S
R
K
V
D
P
R
F
Site 37
S732
P
K
A
L
Q
R
L
S
R
S
I
V
R
S
R
Site 38
S734
A
L
Q
R
L
S
R
S
I
V
R
S
R
A
H
Site 39
S738
L
S
R
S
I
V
R
S
R
A
H
S
T
A
V
Site 40
S742
I
V
R
S
R
A
H
S
T
A
V
G
I
F
S
Site 41
S876
L
G
V
H
G
L
A
S
S
N
E
T
F
D
G
Site 42
S877
G
V
H
G
L
A
S
S
N
E
T
F
D
G
L
Site 43
T880
G
L
A
S
S
N
E
T
F
D
G
L
D
C
P
Site 44
T919
H
A
Q
Q
V
E
S
T
A
R
L
D
F
L
W
Site 45
Y943
E
M
E
E
L
Q
A
Y
N
R
R
L
L
H
N
Site 46
Y971
E
R
R
N
D
E
L
Y
Y
Q
S
C
E
C
V
Site 47
Y972
R
R
N
D
E
L
Y
Y
Q
S
C
E
C
V
A
Site 48
Y992
I
A
N
F
S
E
F
Y
V
E
L
E
A
N
N
Site 49
S1020
A
D
F
D
E
I
I
S
E
E
R
F
R
Q
L
Site 50
T1032
R
Q
L
E
K
I
K
T
I
G
S
T
Y
M
A
Site 51
S1041
G
S
T
Y
M
A
A
S
G
L
N
A
S
T
Y
Site 52
S1046
A
A
S
G
L
N
A
S
T
Y
D
Q
V
G
R
Site 53
Y1048
S
G
L
N
A
S
T
Y
D
Q
V
G
R
S
H
Site 54
Y1104
I
G
A
R
K
P
Q
Y
D
I
W
G
N
T
V
Site 55
S1114
W
G
N
T
V
N
V
S
S
R
M
D
S
T
G
Site 56
S1115
G
N
T
V
N
V
S
S
R
M
D
S
T
G
V
Site 57
S1119
N
V
S
S
R
M
D
S
T
G
V
P
D
R
I
Site 58
T1120
V
S
S
R
M
D
S
T
G
V
P
D
R
I
Q
Site 59
T1130
P
D
R
I
Q
V
T
T
D
L
Y
Q
V
L
A
Site 60
T1159
K
G
K
G
E
M
T
T
Y
F
L
N
G
G
P
Site 61
Y1160
G
K
G
E
M
T
T
Y
F
L
N
G
G
P
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation