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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ARHGEF9
Full Name:
Rho guanine nucleotide exchange factor 9
Alias:
Collybistin;PEM-2 homolog;Rac/Cdc42 guanine nucleotide exchange factor 9
Type:
Mass (Da):
60982
Number AA:
516
UniProt ID:
O43307
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T2
_
_
_
_
_
_
M
T
L
L
I
T
G
D
S
Site 2
S41
V
I
K
V
L
D
A
S
N
K
D
W
W
W
G
Site 3
S77
D
E
V
E
E
G
P
S
D
V
Q
N
G
H
L
Site 4
S88
N
G
H
L
D
P
N
S
D
C
L
C
L
G
R
Site 5
Y118
I
M
S
T
E
R
H
Y
I
K
H
L
K
D
I
Site 6
Y129
L
K
D
I
C
E
G
Y
L
K
Q
C
R
K
R
Site 7
S141
R
K
R
R
D
M
F
S
D
E
Q
L
K
V
I
Site 8
Y170
V
R
D
L
E
K
Q
Y
N
N
D
D
P
H
L
Site 9
S178
N
N
D
D
P
H
L
S
E
I
G
P
C
F
L
Site 10
Y217
K
L
M
K
D
S
R
Y
Q
H
F
F
E
A
C
Site 11
Y259
Q
L
A
E
L
L
K
Y
T
A
Q
D
H
S
D
Site 12
S265
K
Y
T
A
Q
D
H
S
D
Y
R
Y
V
A
A
Site 13
Y267
T
A
Q
D
H
S
D
Y
R
Y
V
A
A
A
L
Site 14
Y269
Q
D
H
S
D
Y
R
Y
V
A
A
A
L
A
V
Site 15
T281
L
A
V
M
R
N
V
T
Q
Q
I
N
E
R
K
Site 16
S316
G
E
D
I
L
D
R
S
S
E
L
I
Y
T
G
Site 17
S317
E
D
I
L
D
R
S
S
E
L
I
Y
T
G
E
Site 18
Y321
D
R
S
S
E
L
I
Y
T
G
E
M
A
W
I
Site 19
T322
R
S
S
E
L
I
Y
T
G
E
M
A
W
I
Y
Site 20
Y329
T
G
E
M
A
W
I
Y
Q
P
Y
G
R
N
Q
Site 21
Y332
M
A
W
I
Y
Q
P
Y
G
R
N
Q
Q
R
V
Site 22
Y361
L
I
R
R
D
I
L
Y
Y
K
G
R
I
D
M
Site 23
Y362
I
R
R
D
I
L
Y
Y
K
G
R
I
D
M
D
Site 24
Y371
G
R
I
D
M
D
K
Y
E
V
V
D
I
E
D
Site 25
S438
E
K
I
G
F
E
I
S
E
N
Q
K
R
Q
A
Site 26
T448
Q
K
R
Q
A
A
M
T
V
R
K
V
P
K
Q
Site 27
S460
P
K
Q
K
G
V
N
S
A
R
S
V
P
P
S
Site 28
S463
K
G
V
N
S
A
R
S
V
P
P
S
Y
P
P
Site 29
S467
S
A
R
S
V
P
P
S
Y
P
P
P
Q
D
P
Site 30
Y468
A
R
S
V
P
P
S
Y
P
P
P
Q
D
P
L
Site 31
Y480
D
P
L
N
H
G
Q
Y
L
V
P
D
G
I
A
Site 32
S489
V
P
D
G
I
A
Q
S
Q
V
F
E
F
T
E
Site 33
S500
E
F
T
E
P
K
R
S
Q
S
P
F
W
Q
N
Site 34
S502
T
E
P
K
R
S
Q
S
P
F
W
Q
N
F
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation