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Updated November 2019
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Protein Info
Short Name:
HISPPD1
Full Name:
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2
Alias:
EC 2.7.4.21; EC 2.7.4.24; FLJ21506; KIAA0433; VIP2
Type:
Kinase, lipid; EC 2.7.4.24; EC 2.7.4.21
Mass (Da):
140407
Number AA:
1243
UniProt ID:
O43314
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0003993
GO:0033857
PhosphoSite+
KinaseNET
Biological Process:
GO:0006020
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T14
F
F
V
G
P
E
D
T
E
I
N
P
G
N
Y
Site 2
Y21
T
E
I
N
P
G
N
Y
R
H
F
F
H
H
A
Site 3
S38
D
D
E
E
E
D
D
S
P
P
E
R
Q
I
V
Site 4
S50
D
D
E
E
E
D
D
S
P
P
E
R
Q
I
V
Site 5
S55
I
C
S
M
A
K
K
S
K
S
K
P
M
K
E
Site 6
S57
S
M
A
K
K
S
K
S
K
P
M
K
E
I
L
Site 7
S102
D
C
L
I
S
F
H
S
K
G
F
P
L
D
K
Site 8
Y138
I
Q
D
R
R
E
V
Y
S
I
L
Q
A
E
G
Site 9
S139
Q
D
R
R
E
V
Y
S
I
L
Q
A
E
G
I
Site 10
Y151
E
G
I
L
L
P
R
Y
A
I
L
N
R
D
P
Site 11
S190
P
F
V
E
K
P
V
S
A
E
D
H
N
V
Y
Site 12
Y197
S
A
E
D
H
N
V
Y
I
Y
Y
P
T
S
A
Site 13
Y199
E
D
H
N
V
Y
I
Y
Y
P
T
S
A
G
G
Site 14
Y200
D
H
N
V
Y
I
Y
Y
P
T
S
A
G
G
G
Site 15
S203
V
Y
I
Y
Y
P
T
S
A
G
G
G
S
Q
R
Site 16
S208
P
T
S
A
G
G
G
S
Q
R
L
F
R
K
I
Site 17
S217
R
L
F
R
K
I
G
S
R
S
S
V
Y
S
P
Site 18
S219
F
R
K
I
G
S
R
S
S
V
Y
S
P
E
S
Site 19
S220
R
K
I
G
S
R
S
S
V
Y
S
P
E
S
N
Site 20
Y222
I
G
S
R
S
S
V
Y
S
P
E
S
N
V
R
Site 21
S223
G
S
R
S
S
V
Y
S
P
E
S
N
V
R
K
Site 22
S226
S
S
V
Y
S
P
E
S
N
V
R
K
T
G
S
Site 23
T231
P
E
S
N
V
R
K
T
G
S
Y
I
Y
E
E
Site 24
Y234
N
V
R
K
T
G
S
Y
I
Y
E
E
F
M
P
Site 25
Y236
R
K
T
G
S
Y
I
Y
E
E
F
M
P
T
D
Site 26
T242
I
Y
E
E
F
M
P
T
D
G
T
D
V
K
V
Site 27
T245
E
F
M
P
T
D
G
T
D
V
K
V
Y
T
V
Site 28
Y250
D
G
T
D
V
K
V
Y
T
V
G
P
D
Y
A
Site 29
T251
G
T
D
V
K
V
Y
T
V
G
P
D
Y
A
H
Site 30
Y256
V
Y
T
V
G
P
D
Y
A
H
A
E
A
R
K
Site 31
S264
A
H
A
E
A
R
K
S
P
A
L
D
G
K
V
Site 32
S275
D
G
K
V
E
R
D
S
E
G
K
E
V
R
Y
Site 33
Y282
S
E
G
K
E
V
R
Y
P
V
I
L
N
A
R
Site 34
S317
L
L
R
A
N
G
Q
S
Y
V
C
D
V
N
G
Site 35
Y318
L
R
A
N
G
Q
S
Y
V
C
D
V
N
G
F
Site 36
Y334
F
V
K
N
S
M
K
Y
Y
D
D
C
A
K
I
Site 37
Y335
V
K
N
S
M
K
Y
Y
D
D
C
A
K
I
L
Site 38
S359
P
Q
F
H
I
P
W
S
I
P
L
E
A
E
D
Site 39
T393
V
I
R
H
G
D
R
T
P
K
Q
K
M
K
M
Site 40
Y417
L
F
E
K
C
D
G
Y
K
S
G
K
L
K
L
Site 41
S419
E
K
C
D
G
Y
K
S
G
K
L
K
L
K
K
Site 42
S450
E
L
G
Q
N
N
D
S
E
I
E
E
N
K
P
Site 43
T464
P
K
L
E
Q
L
K
T
V
L
E
M
Y
G
H
Site 44
T482
I
N
R
K
V
Q
L
T
Y
L
P
H
G
C
P
Site 45
Y483
N
R
K
V
Q
L
T
Y
L
P
H
G
C
P
K
Site 46
T491
L
P
H
G
C
P
K
T
S
S
E
E
E
D
S
Site 47
S492
P
H
G
C
P
K
T
S
S
E
E
E
D
S
R
Site 48
S493
H
G
C
P
K
T
S
S
E
E
E
D
S
R
R
Site 49
S498
T
S
S
E
E
E
D
S
R
R
E
E
P
S
L
Site 50
S504
D
S
R
R
E
E
P
S
L
L
L
V
L
K
W
Site 51
T516
L
K
W
G
G
E
L
T
P
A
G
R
V
Q
A
Site 52
Y534
G
R
A
F
R
C
M
Y
P
G
G
Q
G
D
Y
Site 53
Y541
Y
P
G
G
Q
G
D
Y
A
G
F
P
G
C
G
Site 54
S554
C
G
L
L
R
L
H
S
T
Y
R
H
D
L
K
Site 55
T555
G
L
L
R
L
H
S
T
Y
R
H
D
L
K
I
Site 56
Y556
L
L
R
L
H
S
T
Y
R
H
D
L
K
I
Y
Site 57
Y563
Y
R
H
D
L
K
I
Y
A
S
D
E
G
R
V
Site 58
S565
H
D
L
K
I
Y
A
S
D
E
G
R
V
Q
M
Site 59
T573
D
E
G
R
V
Q
M
T
A
A
A
F
A
K
G
Site 60
S607
N
M
N
G
L
L
D
S
D
S
D
S
L
S
S
Site 61
S609
N
G
L
L
D
S
D
S
D
S
L
S
S
C
Q
Site 62
S611
L
L
D
S
D
S
D
S
L
S
S
C
Q
Q
R
Site 63
S613
D
S
D
S
D
S
L
S
S
C
Q
Q
R
V
K
Site 64
T634
L
Q
K
D
R
D
F
T
A
E
D
Y
E
K
L
Site 65
Y638
R
D
F
T
A
E
D
Y
E
K
L
T
P
S
G
Site 66
T642
A
E
D
Y
E
K
L
T
P
S
G
S
I
S
L
Site 67
S644
D
Y
E
K
L
T
P
S
G
S
I
S
L
I
K
Site 68
S646
E
K
L
T
P
S
G
S
I
S
L
I
K
S
M
Site 69
T662
L
I
K
N
P
V
K
T
C
D
K
V
Y
S
L
Site 70
S668
K
T
C
D
K
V
Y
S
L
I
Q
S
L
T
S
Site 71
S672
K
V
Y
S
L
I
Q
S
L
T
S
Q
I
R
H
Site 72
T674
Y
S
L
I
Q
S
L
T
S
Q
I
R
H
R
M
Site 73
S675
S
L
I
Q
S
L
T
S
Q
I
R
H
R
M
E
Site 74
S686
H
R
M
E
D
P
K
S
S
D
I
Q
L
Y
H
Site 75
S687
R
M
E
D
P
K
S
S
D
I
Q
L
Y
H
S
Site 76
Y692
K
S
S
D
I
Q
L
Y
H
S
E
T
L
E
L
Site 77
S694
S
D
I
Q
L
Y
H
S
E
T
L
E
L
M
L
Site 78
T696
I
Q
L
Y
H
S
E
T
L
E
L
M
L
R
R
Site 79
S705
E
L
M
L
R
R
W
S
K
L
E
K
D
F
K
Site 80
T713
K
L
E
K
D
F
K
T
K
N
G
R
Y
D
I
Site 81
S721
K
N
G
R
Y
D
I
S
K
I
P
D
I
Y
D
Site 82
Y727
I
S
K
I
P
D
I
Y
D
C
I
K
Y
D
V
Site 83
Y732
D
I
Y
D
C
I
K
Y
D
V
Q
H
N
G
S
Site 84
T745
G
S
L
K
L
E
N
T
M
E
L
Y
R
L
S
Site 85
T767
I
P
Q
E
Y
G
I
T
K
A
E
K
L
E
I
Site 86
Y778
K
L
E
I
A
K
G
Y
C
T
P
L
V
R
K
Site 87
T780
E
I
A
K
G
Y
C
T
P
L
V
R
K
I
R
Site 88
T798
Q
R
T
Q
D
D
D
T
V
N
K
L
H
P
V
Site 89
Y806
V
N
K
L
H
P
V
Y
S
R
G
V
L
S
P
Site 90
S807
N
K
L
H
P
V
Y
S
R
G
V
L
S
P
E
Site 91
S812
V
Y
S
R
G
V
L
S
P
E
R
H
V
R
T
Site 92
Y822
R
H
V
R
T
R
L
Y
F
T
S
E
S
H
V
Site 93
S825
R
T
R
L
Y
F
T
S
E
S
H
V
H
S
L
Site 94
S827
R
L
Y
F
T
S
E
S
H
V
H
S
L
L
S
Site 95
S831
T
S
E
S
H
V
H
S
L
L
S
I
L
R
Y
Site 96
Y856
Q
W
K
R
A
M
D
Y
L
N
V
V
N
E
L
Site 97
Y874
T
Q
I
V
I
M
L
Y
E
D
P
N
K
D
L
Site 98
S882
E
D
P
N
K
D
L
S
S
E
E
R
F
H
V
Site 99
S883
D
P
N
K
D
L
S
S
E
E
R
F
H
V
E
Site 100
S894
F
H
V
E
L
H
F
S
P
G
A
K
G
C
E
Site 101
S908
E
E
D
K
N
L
P
S
G
Y
G
Y
R
P
A
Site 102
Y912
N
L
P
S
G
Y
G
Y
R
P
A
S
R
E
N
Site 103
S916
G
Y
G
Y
R
P
A
S
R
E
N
E
G
R
R
Site 104
S936
N
D
D
E
P
H
T
S
K
R
D
E
V
D
R
Site 105
S962
P
I
H
I
H
R
K
S
P
L
P
R
S
R
K
Site 106
S967
R
K
S
P
L
P
R
S
R
K
T
A
T
N
D
Site 107
T970
P
L
P
R
S
R
K
T
A
T
N
D
E
E
S
Site 108
T972
P
R
S
R
K
T
A
T
N
D
E
E
S
P
L
Site 109
S977
T
A
T
N
D
E
E
S
P
L
S
V
S
S
P
Site 110
S980
N
D
E
E
S
P
L
S
V
S
S
P
E
G
T
Site 111
S982
E
E
S
P
L
S
V
S
S
P
E
G
T
G
T
Site 112
S983
E
S
P
L
S
V
S
S
P
E
G
T
G
T
W
Site 113
T987
S
V
S
S
P
E
G
T
G
T
W
L
H
Y
T
Site 114
T989
S
S
P
E
G
T
G
T
W
L
H
Y
T
S
G
Site 115
Y993
G
T
G
T
W
L
H
Y
T
S
G
V
G
T
G
Site 116
T994
T
G
T
W
L
H
Y
T
S
G
V
G
T
G
R
Site 117
S995
G
T
W
L
H
Y
T
S
G
V
G
T
G
R
R
Site 118
T999
H
Y
T
S
G
V
G
T
G
R
R
R
R
R
S
Site 119
S1006
T
G
R
R
R
R
R
S
G
E
Q
I
T
S
S
Site 120
T1011
R
R
S
G
E
Q
I
T
S
S
P
V
S
P
K
Site 121
S1012
R
S
G
E
Q
I
T
S
S
P
V
S
P
K
S
Site 122
S1013
S
G
E
Q
I
T
S
S
P
V
S
P
K
S
L
Site 123
S1016
Q
I
T
S
S
P
V
S
P
K
S
L
A
F
T
Site 124
S1019
S
S
P
V
S
P
K
S
L
A
F
T
S
S
I
Site 125
T1023
R
R
S
G
E
Q
I
T
S
S
P
V
S
P
K
Site 126
S1024
R
S
G
E
Q
I
T
S
S
P
V
S
P
K
S
Site 127
S1025
K
S
L
A
F
T
S
S
I
F
G
S
W
Q
Q
Site 128
S1029
F
T
S
S
I
F
G
S
W
Q
Q
V
V
S
E
Site 129
Y1040
V
V
S
E
N
A
N
Y
L
R
T
P
R
T
L
Site 130
T1043
E
N
A
N
Y
L
R
T
P
R
T
L
V
E
Q
Site 131
T1046
N
Y
L
R
T
P
R
T
L
V
E
Q
K
Q
N
Site 132
T1055
V
E
Q
K
Q
N
P
T
V
G
S
H
C
A
G
Site 133
S1058
K
Q
N
P
T
V
G
S
H
C
A
G
L
F
S
Site 134
S1073
T
S
V
L
G
G
S
S
S
A
P
N
L
Q
D
Site 135
S1074
S
V
L
G
G
S
S
S
A
P
N
L
Q
D
Y
Site 136
Y1081
S
A
P
N
L
Q
D
Y
A
R
T
H
R
K
K
Site 137
T1084
N
L
Q
D
Y
A
R
T
H
R
K
K
L
T
S
Site 138
T1090
R
T
H
R
K
K
L
T
S
S
G
C
I
D
D
Site 139
S1091
T
H
R
K
K
L
T
S
S
G
C
I
D
D
A
Site 140
S1092
H
R
K
K
L
T
S
S
G
C
I
D
D
A
T
Site 141
T1099
S
G
C
I
D
D
A
T
R
G
S
A
V
K
R
Site 142
S1102
I
D
D
A
T
R
G
S
A
V
K
R
F
S
I
Site 143
S1108
G
S
A
V
K
R
F
S
I
S
F
A
R
H
P
Site 144
S1110
A
V
K
R
F
S
I
S
F
A
R
H
P
T
N
Site 145
T1116
I
S
F
A
R
H
P
T
N
G
F
E
L
Y
S
Site 146
S1139
E
T
L
H
N
A
L
S
L
K
Q
V
D
E
F
Site 147
S1149
Q
V
D
E
F
L
A
S
I
A
S
P
S
S
D
Site 148
S1152
E
F
L
A
S
I
A
S
P
S
S
D
V
P
R
Site 149
S1155
A
S
I
A
S
P
S
S
D
V
P
R
K
T
A
Site 150
T1161
S
S
D
V
P
R
K
T
A
E
I
S
S
T
A
Site 151
S1165
P
R
K
T
A
E
I
S
S
T
A
L
R
S
S
Site 152
S1166
R
K
T
A
E
I
S
S
T
A
L
R
S
S
P
Site 153
T1167
K
T
A
E
I
S
S
T
A
L
R
S
S
P
I
Site 154
S1171
I
S
S
T
A
L
R
S
S
P
I
M
R
K
K
Site 155
S1172
S
S
T
A
L
R
S
S
P
I
M
R
K
K
V
Site 156
S1180
P
I
M
R
K
K
V
S
L
N
T
Y
T
P
A
Site 157
T1183
R
K
K
V
S
L
N
T
Y
T
P
A
K
I
L
Site 158
Y1184
K
K
V
S
L
N
T
Y
T
P
A
K
I
L
P
Site 159
T1185
K
V
S
L
N
T
Y
T
P
A
K
I
L
P
T
Site 160
T1192
T
P
A
K
I
L
P
T
P
P
A
T
L
K
S
Site 161
T1196
K
V
S
L
N
T
Y
T
P
A
K
I
L
P
T
Site 162
S1199
T
P
P
A
T
L
K
S
T
K
A
S
S
K
P
Site 163
S1203
T
L
K
S
T
K
A
S
S
K
P
A
T
S
G
Site 164
S1204
L
K
S
T
K
A
S
S
K
P
A
T
S
G
P
Site 165
T1208
K
A
S
S
K
P
A
T
S
G
P
S
S
A
V
Site 166
S1209
A
S
S
K
P
A
T
S
G
P
S
S
A
V
V
Site 167
S1213
P
A
T
S
G
P
S
S
A
V
V
P
N
T
S
Site 168
T1219
S
S
A
V
V
P
N
T
S
S
R
K
K
N
I
Site 169
S1220
S
A
V
V
P
N
T
S
S
R
K
K
N
I
T
Site 170
T1227
S
S
R
K
K
N
I
T
S
K
T
E
T
H
E
Site 171
T1230
K
K
N
I
T
S
K
T
E
T
H
E
H
K
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation