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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RASA4
Full Name:
Ras GTPase-activating protein 4
Alias:
calcium-promoted Ras inactivator; CAPRI; GAPL; KIAA0538; ras GTPase-activating 4; ras p21 protein activator 4; rasGAP-activating-like 2
Type:
Mass (Da):
90458
Number AA:
803
UniProt ID:
O43374
International Prot ID:
IPI00012059
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0019898
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005096
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0007242
GO:0051056
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y8
M
A
K
R
S
S
L
Y
I
R
I
V
E
G
K
Site 2
T23
N
L
P
A
K
D
I
T
G
S
S
D
P
Y
C
Site 3
S26
A
K
D
I
T
G
S
S
D
P
Y
C
I
V
K
Site 4
Y29
I
T
G
S
S
D
P
Y
C
I
V
K
V
D
N
Site 5
Y57
C
P
F
W
G
E
E
Y
Q
V
H
L
P
P
T
Site 6
S79
V
M
D
E
D
A
L
S
R
D
D
V
I
G
K
Site 7
T93
K
V
C
L
T
R
D
T
I
A
S
H
P
K
G
Site 8
S96
L
T
R
D
T
I
A
S
H
P
K
G
F
S
G
Site 9
S138
R
A
C
R
L
R
C
S
V
L
E
A
R
D
L
Site 10
T153
A
P
K
D
R
N
G
T
S
D
P
F
V
R
V
Site 11
S154
P
K
D
R
N
G
T
S
D
P
F
V
R
V
R
Site 12
Y162
D
P
F
V
R
V
R
Y
K
G
R
T
R
E
T
Site 13
T166
R
V
R
Y
K
G
R
T
R
E
T
S
I
V
K
Site 14
T169
Y
K
G
R
T
R
E
T
S
I
V
K
K
S
C
Site 15
S170
K
G
R
T
R
E
T
S
I
V
K
K
S
C
Y
Site 16
Y177
S
I
V
K
K
S
C
Y
P
R
W
N
E
T
F
Site 17
S239
F
R
L
Q
P
D
Q
S
K
S
R
R
H
D
E
Site 18
S241
L
Q
P
D
Q
S
K
S
R
R
H
D
E
G
N
Site 19
S251
H
D
E
G
N
L
G
S
L
Q
L
E
V
R
L
Site 20
T262
E
V
R
L
R
D
E
T
V
L
P
S
S
Y
Y
Site 21
S267
D
E
T
V
L
P
S
S
Y
Y
Q
P
L
V
H
Site 22
Y268
E
T
V
L
P
S
S
Y
Y
Q
P
L
V
H
L
Site 23
T300
L
I
E
E
T
T
S
T
E
C
R
Q
D
V
A
Site 24
S333
L
L
F
Q
L
E
L
S
R
T
S
E
T
N
T
Site 25
T335
F
Q
L
E
L
S
R
T
S
E
T
N
T
L
F
Site 26
S336
Q
L
E
L
S
R
T
S
E
T
N
T
L
F
R
Site 27
T340
S
R
T
S
E
T
N
T
L
F
R
S
N
S
L
Site 28
S344
E
T
N
T
L
F
R
S
N
S
L
A
S
K
S
Site 29
S346
N
T
L
F
R
S
N
S
L
A
S
K
S
M
E
Site 30
S349
F
R
S
N
S
L
A
S
K
S
M
E
S
F
L
Site 31
S351
S
N
S
L
A
S
K
S
M
E
S
F
L
K
V
Site 32
Y381
K
V
F
E
E
K
K
Y
V
E
L
D
P
S
K
Site 33
S387
K
Y
V
E
L
D
P
S
K
V
E
V
K
D
V
Site 34
T404
S
G
L
H
R
P
Q
T
E
A
E
V
L
E
Q
Site 35
S428
G
A
L
L
S
A
L
S
R
S
V
R
A
C
P
Site 36
T441
C
P
A
V
V
R
A
T
F
R
Q
L
F
R
R
Site 37
T496
E
R
H
A
D
A
R
T
S
R
T
L
L
L
L
Site 38
S497
R
H
A
D
A
R
T
S
R
T
L
L
L
L
A
Site 39
T515
Q
N
V
G
N
M
D
T
P
A
S
R
A
K
E
Site 40
S518
G
N
M
D
T
P
A
S
R
A
K
E
A
W
M
Site 41
T531
W
M
E
P
L
Q
P
T
V
R
Q
G
V
A
Q
Site 42
T544
A
Q
L
K
D
F
I
T
K
L
V
D
I
E
E
Site 43
S562
L
D
L
Q
R
T
L
S
L
Q
A
P
P
V
K
Site 44
T578
G
P
L
F
I
H
R
T
K
G
K
G
P
L
M
Site 45
S586
K
G
K
G
P
L
M
S
S
S
F
K
K
L
Y
Site 46
S587
G
K
G
P
L
M
S
S
S
F
K
K
L
Y
F
Site 47
S588
K
G
P
L
M
S
S
S
F
K
K
L
Y
F
S
Site 48
Y593
S
S
S
F
K
K
L
Y
F
S
L
T
T
E
A
Site 49
S595
S
F
K
K
L
Y
F
S
L
T
T
E
A
L
S
Site 50
S602
S
L
T
T
E
A
L
S
F
A
K
T
P
S
S
Site 51
T606
E
A
L
S
F
A
K
T
P
S
S
K
K
S
A
Site 52
S608
L
S
F
A
K
T
P
S
S
K
K
S
A
L
I
Site 53
S609
S
F
A
K
T
P
S
S
K
K
S
A
L
I
K
Site 54
S612
K
T
P
S
S
K
K
S
A
L
I
K
L
A
N
Site 55
S630
A
E
K
V
E
E
K
S
F
G
G
S
H
V
M
Site 56
S634
E
E
K
S
F
G
G
S
H
V
M
Q
V
I
Y
Site 57
Y641
S
H
V
M
Q
V
I
Y
T
D
D
A
G
R
P
Site 58
T650
D
D
A
G
R
P
Q
T
A
Y
L
Q
C
K
C
Site 59
Y652
A
G
R
P
Q
T
A
Y
L
Q
C
K
C
V
N
Site 60
S666
N
E
L
N
Q
W
L
S
A
L
R
K
V
S
I
Site 61
T676
R
K
V
S
I
N
N
T
G
L
L
G
S
Y
H
Site 62
S681
N
N
T
G
L
L
G
S
Y
H
P
G
V
F
R
Site 63
T708
T
G
Q
G
C
D
K
T
R
S
R
V
T
L
Q
Site 64
S710
Q
G
C
D
K
T
R
S
R
V
T
L
Q
E
W
Site 65
T713
D
K
T
R
S
R
V
T
L
Q
E
W
N
D
P
Site 66
S749
W
E
R
H
R
E
L
S
G
G
A
E
A
G
T
Site 67
T756
S
G
G
A
E
A
G
T
V
P
T
S
P
G
K
Site 68
T759
A
E
A
G
T
V
P
T
S
P
G
K
V
P
E
Site 69
S760
E
A
G
T
V
P
T
S
P
G
K
V
P
E
D
Site 70
S768
P
G
K
V
P
E
D
S
L
A
R
L
L
R
V
Site 71
S784
Q
D
L
R
E
A
H
S
S
S
P
A
G
S
P
Site 72
S785
D
L
R
E
A
H
S
S
S
P
A
G
S
P
P
Site 73
S786
L
R
E
A
H
S
S
S
P
A
G
S
P
P
S
Site 74
S790
H
S
S
S
P
A
G
S
P
P
S
E
P
N
C
Site 75
S793
S
P
A
G
S
P
P
S
E
P
N
C
L
L
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation