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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PRPF3
Full Name:
U4/U6 small nuclear ribonucleoprotein Prp3
Alias:
HPRP3; HPRP3P; Pre-mRNA-splicing factor 3; PRP3; PRP3 Prp3p; RP18
Type:
RNA processing
Mass (Da):
77529
Number AA:
683
UniProt ID:
O43395
International Prot ID:
IPI00005861
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0005681
GO:0016604
Uniprot
OncoNet
Molecular Function:
GO:0003824
GO:0005488
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0000375
GO:0000377
GO:0000398
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T18
L
K
P
W
I
E
K
T
V
K
R
V
L
G
F
Site 2
S58
L
K
P
F
L
D
D
S
T
L
R
F
V
D
K
Site 3
T59
K
P
F
L
D
D
S
T
L
R
F
V
D
K
L
Site 4
S75
E
A
V
E
E
G
R
S
S
R
H
S
K
S
S
Site 5
S76
A
V
E
E
G
R
S
S
R
H
S
K
S
S
S
Site 6
S79
E
G
R
S
S
R
H
S
K
S
S
S
D
R
S
Site 7
S81
R
S
S
R
H
S
K
S
S
S
D
R
S
R
K
Site 8
S82
S
S
R
H
S
K
S
S
S
D
R
S
R
K
R
Site 9
S83
S
R
H
S
K
S
S
S
D
R
S
R
K
R
E
Site 10
S86
S
K
S
S
S
D
R
S
R
K
R
E
L
K
E
Site 11
S99
K
E
V
F
G
D
D
S
E
I
S
K
E
S
S
Site 12
S102
F
G
D
D
S
E
I
S
K
E
S
S
G
V
K
Site 13
S105
D
S
E
I
S
K
E
S
S
G
V
K
K
R
R
Site 14
S106
S
E
I
S
K
E
S
S
G
V
K
K
R
R
I
Site 15
S131
E
V
I
P
G
P
P
S
E
S
P
G
M
L
T
Site 16
S133
I
P
G
P
P
S
E
S
P
G
M
L
T
K
L
Site 17
S161
E
E
R
K
K
Q
L
S
F
I
S
P
P
T
P
Site 18
S164
K
K
Q
L
S
F
I
S
P
P
T
P
Q
P
K
Site 19
T167
L
S
F
I
S
P
P
T
P
Q
P
K
T
P
S
Site 20
T172
P
P
T
P
Q
P
K
T
P
S
S
S
Q
P
E
Site 21
S175
P
Q
P
K
T
P
S
S
S
Q
P
E
R
L
P
Site 22
S176
Q
P
K
T
P
S
S
S
Q
P
E
R
L
P
I
Site 23
T186
E
R
L
P
I
G
N
T
I
Q
P
S
Q
A
A
Site 24
T194
I
Q
P
S
Q
A
A
T
F
M
N
D
A
I
E
Site 25
T254
L
K
D
Q
T
K
P
T
P
L
I
L
D
E
Q
Site 26
T264
I
L
D
E
Q
G
R
T
V
D
A
T
G
K
E
Site 27
T268
Q
G
R
T
V
D
A
T
G
K
E
I
E
L
T
Site 28
T275
T
G
K
E
I
E
L
T
H
R
M
P
T
L
K
Site 29
T280
E
L
T
H
R
M
P
T
L
K
A
N
I
R
A
Site 30
S302
Q
Q
L
K
E
K
P
S
E
D
M
E
S
N
T
Site 31
S307
K
P
S
E
D
M
E
S
N
T
F
F
D
P
R
Site 32
T309
S
E
D
M
E
S
N
T
F
F
D
P
R
V
S
Site 33
S316
T
F
F
D
P
R
V
S
I
A
P
S
Q
R
Q
Site 34
S320
P
R
V
S
I
A
P
S
Q
R
Q
R
R
T
F
Site 35
T326
P
S
Q
R
Q
R
R
T
F
K
F
H
D
K
G
Site 36
T344
K
I
A
Q
R
L
R
T
K
A
Q
L
E
K
L
Site 37
S356
E
K
L
Q
A
E
I
S
Q
A
A
R
K
T
G
Site 38
T362
I
S
Q
A
A
R
K
T
G
I
H
T
S
T
R
Site 39
S367
R
K
T
G
I
H
T
S
T
R
L
A
L
I
A
Site 40
T402
I
P
N
G
F
D
L
T
E
E
N
P
K
R
E
Site 41
Y411
E
N
P
K
R
E
D
Y
F
G
I
T
N
L
V
Site 42
T432
N
P
P
V
D
N
D
T
P
V
T
L
G
V
Y
Site 43
T435
V
D
N
D
T
P
V
T
L
G
V
Y
L
T
K
Site 44
Y439
T
P
V
T
L
G
V
Y
L
T
K
K
E
Q
K
Site 45
T452
Q
K
K
L
R
R
Q
T
R
R
E
A
Q
K
E
Site 46
S479
P
E
P
K
V
R
I
S
N
L
M
R
V
L
G
Site 47
T494
T
E
A
V
Q
D
P
T
K
V
E
A
H
V
R
Site 48
T521
A
N
A
A
R
K
L
T
A
E
Q
R
K
V
K
Site 49
S538
K
K
L
K
E
D
I
S
Q
G
V
H
I
S
V
Site 50
Y546
Q
G
V
H
I
S
V
Y
R
V
R
N
L
S
N
Site 51
S552
V
Y
R
V
R
N
L
S
N
P
A
K
K
F
K
Site 52
T608
R
I
K
W
D
E
Q
T
S
N
T
K
G
D
D
Site 53
T611
W
D
E
Q
T
S
N
T
K
G
D
D
D
E
E
Site 54
S619
K
G
D
D
D
E
E
S
D
E
E
A
V
K
K
Site 55
S642
E
G
T
A
K
D
R
S
F
G
E
M
K
F
K
Site 56
S675
H
Y
W
D
L
A
L
S
E
S
V
L
E
S
T
Site 57
S677
W
D
L
A
L
S
E
S
V
L
E
S
T
D
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation