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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
COCH
Full Name:
Cochlin
Alias:
COCH-5B2
Type:
Mass (Da):
59483
Number AA:
550
UniProt ID:
O43405
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S84
A
V
H
R
G
V
I
S
N
S
G
G
P
V
R
Site 2
S86
H
R
G
V
I
S
N
S
G
G
P
V
R
V
Y
Site 3
Y93
S
G
G
P
V
R
V
Y
S
L
P
G
R
E
N
Site 4
S94
G
G
P
V
R
V
Y
S
L
P
G
R
E
N
Y
Site 5
Y101
S
L
P
G
R
E
N
Y
S
S
V
D
A
N
G
Site 6
S103
P
G
R
E
N
Y
S
S
V
D
A
N
G
I
Q
Site 7
S111
V
D
A
N
G
I
Q
S
Q
M
L
S
R
W
S
Site 8
S115
G
I
Q
S
Q
M
L
S
R
W
S
A
S
F
T
Site 9
S118
S
Q
M
L
S
R
W
S
A
S
F
T
V
T
K
Site 10
S120
M
L
S
R
W
S
A
S
F
T
V
T
K
G
K
Site 11
T122
S
R
W
S
A
S
F
T
V
T
K
G
K
S
S
Site 12
T124
W
S
A
S
F
T
V
T
K
G
K
S
S
T
Q
Site 13
S129
T
V
T
K
G
K
S
S
T
Q
E
A
T
G
Q
Site 14
S139
E
A
T
G
Q
A
V
S
T
A
H
P
P
T
G
Site 15
T140
A
T
G
Q
A
V
S
T
A
H
P
P
T
G
K
Site 16
T152
T
G
K
R
L
K
K
T
P
E
K
K
T
G
N
Site 17
Y218
E
H
P
K
I
E
F
Y
L
K
N
F
T
S
A
Site 18
S242
V
G
F
R
G
G
N
S
N
T
G
K
A
L
K
Site 19
T257
H
T
A
Q
K
F
F
T
V
D
A
G
V
R
K
Site 20
S279
V
F
I
D
G
W
P
S
D
D
I
E
E
A
G
Site 21
T339
H
M
P
N
W
F
G
T
T
K
Y
V
K
P
L
Site 22
T340
M
P
N
W
F
G
T
T
K
Y
V
K
P
L
V
Site 23
Y342
N
W
F
G
T
T
K
Y
V
K
P
L
V
Q
K
Site 24
S377
F
L
I
D
G
S
S
S
V
G
D
S
N
F
R
Site 25
S381
G
S
S
S
V
G
D
S
N
F
R
L
M
L
E
Site 26
S420
Y
D
Q
R
T
E
F
S
F
T
D
Y
S
T
K
Site 27
T422
Q
R
T
E
F
S
F
T
D
Y
S
T
K
E
N
Site 28
Y424
T
E
F
S
F
T
D
Y
S
T
K
E
N
V
L
Site 29
S441
I
R
N
I
R
Y
M
S
G
G
T
A
T
G
D
Site 30
S464
V
F
G
P
I
R
E
S
P
N
K
N
F
L
V
Site 31
S478
V
I
V
T
D
G
Q
S
Y
D
D
V
Q
G
P
Site 32
Y479
I
V
T
D
G
Q
S
Y
D
D
V
Q
G
P
A
Site 33
S514
D
D
L
K
D
M
A
S
K
P
K
E
S
H
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation