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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MGAM
Full Name:
Maltase-glucoamylase, intestinal
Alias:
Alpha-glucosidase;Glucan 1,4-alpha-glucosidase
Type:
Mass (Da):
209852
Number AA:
1857
UniProt ID:
O43451
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T10
R
K
K
L
K
K
F
T
T
L
E
I
V
L
S
Site 2
S17
T
T
L
E
I
V
L
S
V
L
L
L
V
L
F
Site 3
S27
L
L
V
L
F
I
I
S
I
V
L
I
V
L
L
Site 4
S41
L
A
K
E
S
L
K
S
T
A
P
D
P
G
T
Site 5
T42
A
K
E
S
L
K
S
T
A
P
D
P
G
T
T
Site 6
T48
S
T
A
P
D
P
G
T
T
G
T
P
D
P
G
Site 7
T51
P
D
P
G
T
T
G
T
P
D
P
G
T
T
G
Site 8
T56
T
G
T
P
D
P
G
T
T
G
T
P
D
P
G
Site 9
T57
G
T
P
D
P
G
T
T
G
T
P
D
P
G
T
Site 10
T64
T
G
T
P
D
P
G
T
T
G
T
T
H
A
R
Site 11
T72
T
G
T
T
H
A
R
T
T
G
P
P
D
P
G
Site 12
T73
G
T
T
H
A
R
T
T
G
P
P
D
P
G
T
Site 13
T80
T
G
P
P
D
P
G
T
T
G
T
T
P
V
S
Site 14
T83
P
D
P
G
T
T
G
T
T
P
V
S
A
E
C
Site 15
T84
D
P
G
T
T
G
T
T
P
V
S
A
E
C
P
Site 16
S160
A
R
L
K
N
L
P
S
S
P
V
F
G
S
N
Site 17
S161
R
L
K
N
L
P
S
S
P
V
F
G
S
N
V
Site 18
T191
H
F
K
L
T
D
Q
T
N
N
R
F
E
V
P
Site 19
S204
V
P
H
E
H
V
Q
S
F
S
G
N
A
A
A
Site 20
T214
G
N
A
A
A
S
L
T
Y
Q
V
E
I
S
R
Site 21
S220
L
T
Y
Q
V
E
I
S
R
Q
P
F
S
I
K
Site 22
S225
E
I
S
R
Q
P
F
S
I
K
V
T
R
R
S
Site 23
T229
Q
P
F
S
I
K
V
T
R
R
S
N
N
R
V
Site 24
S232
S
I
K
V
T
R
R
S
N
N
R
V
L
F
D
Site 25
S255
A
D
Q
F
L
Q
L
S
T
R
L
P
S
T
N
Site 26
T256
D
Q
F
L
Q
L
S
T
R
L
P
S
T
N
V
Site 27
S260
Q
L
S
T
R
L
P
S
T
N
V
Y
G
L
G
Site 28
T261
L
S
T
R
L
P
S
T
N
V
Y
G
L
G
E
Site 29
Y264
R
L
P
S
T
N
V
Y
G
L
G
E
H
V
H
Site 30
T291
P
I
F
N
R
D
T
T
P
N
G
N
G
T
N
Site 31
Y300
N
G
N
G
T
N
L
Y
G
A
Q
T
F
F
L
Site 32
T355
F
Y
V
F
L
G
N
T
P
E
Q
V
V
Q
E
Site 33
Y363
P
E
Q
V
V
Q
E
Y
L
E
L
I
G
R
P
Site 34
Y385
L
G
F
H
L
S
R
Y
E
Y
G
T
L
D
N
Site 35
Y387
F
H
L
S
R
Y
E
Y
G
T
L
D
N
M
R
Site 36
T389
L
S
R
Y
E
Y
G
T
L
D
N
M
R
E
V
Site 37
Y416
V
Q
H
A
D
I
D
Y
M
D
E
R
R
D
F
Site 38
T424
M
D
E
R
R
D
F
T
Y
D
S
V
D
F
K
Site 39
Y425
D
E
R
R
D
F
T
Y
D
S
V
D
F
K
G
Site 40
S427
R
R
D
F
T
Y
D
S
V
D
F
K
G
F
P
Site 41
S456
I
I
V
D
P
A
I
S
N
N
S
S
S
S
K
Site 42
S459
D
P
A
I
S
N
N
S
S
S
S
K
P
Y
G
Site 43
S460
P
A
I
S
N
N
S
S
S
S
K
P
Y
G
P
Site 44
S461
A
I
S
N
N
S
S
S
S
K
P
Y
G
P
Y
Site 45
S462
I
S
N
N
S
S
S
S
K
P
Y
G
P
Y
D
Site 46
Y465
N
S
S
S
S
K
P
Y
G
P
Y
D
R
G
S
Site 47
Y468
S
S
K
P
Y
G
P
Y
D
R
G
S
D
M
K
Site 48
S480
D
M
K
I
W
V
N
S
S
D
G
V
T
P
L
Site 49
T496
G
E
V
W
P
G
Q
T
V
F
P
D
Y
T
N
Site 50
Y501
G
Q
T
V
F
P
D
Y
T
N
P
N
C
A
V
Site 51
S540
V
S
N
F
V
D
G
S
V
S
G
C
S
T
N
Site 52
S542
N
F
V
D
G
S
V
S
G
C
S
T
N
N
L
Site 53
T546
G
S
V
S
G
C
S
T
N
N
L
N
N
P
P
Site 54
T555
N
L
N
N
P
P
F
T
P
R
I
L
D
G
Y
Site 55
Y586
Q
Y
D
I
H
N
L
Y
G
Y
S
M
A
V
A
Site 56
T600
A
T
A
E
A
A
K
T
V
F
P
N
K
R
S
Site 57
S607
T
V
F
P
N
K
R
S
F
I
L
T
R
S
T
Site 58
T611
N
K
R
S
F
I
L
T
R
S
T
F
A
G
S
Site 59
S613
R
S
F
I
L
T
R
S
T
F
A
G
S
G
K
Site 60
S618
T
R
S
T
F
A
G
S
G
K
F
A
A
H
W
Site 61
T665
I
C
G
F
A
L
D
T
P
E
E
L
C
R
R
Site 62
S683
L
G
A
F
Y
P
F
S
R
N
H
N
G
Q
G
Site 63
S698
Y
K
D
Q
D
P
A
S
F
G
A
D
S
L
L
Site 64
S703
P
A
S
F
G
A
D
S
L
L
L
N
S
S
R
Site 65
S708
A
D
S
L
L
L
N
S
S
R
H
Y
L
N
I
Site 66
S709
D
S
L
L
L
N
S
S
R
H
Y
L
N
I
R
Site 67
Y712
L
L
N
S
S
R
H
Y
L
N
I
R
Y
T
L
Site 68
S732
T
L
F
F
R
A
H
S
R
G
D
T
V
A
R
Site 69
T736
R
A
H
S
R
G
D
T
V
A
R
P
L
L
H
Site 70
Y746
R
P
L
L
H
E
F
Y
E
D
N
S
T
W
D
Site 71
Y787
Y
V
P
D
A
V
W
Y
D
Y
E
T
G
S
Q
Site 72
Y789
P
D
A
V
W
Y
D
Y
E
T
G
S
Q
V
R
Site 73
Y819
G
L
H
L
R
G
G
Y
I
F
P
T
Q
Q
P
Site 74
T823
R
G
G
Y
I
F
P
T
Q
Q
P
N
T
T
T
Site 75
T864
D
N
G
E
T
K
D
T
V
A
N
K
V
Y
L
Site 76
S887
N
R
L
E
V
N
I
S
Q
S
T
Y
K
D
P
Site 77
Y891
V
N
I
S
Q
S
T
Y
K
D
P
N
N
L
A
Site 78
T907
N
E
I
K
I
L
G
T
E
E
P
S
N
V
T
Site 79
S922
V
K
H
N
G
V
P
S
Q
T
S
P
T
V
T
Site 80
S925
N
G
V
P
S
Q
T
S
P
T
V
T
Y
D
S
Site 81
T927
V
P
S
Q
T
S
P
T
V
T
Y
D
S
N
L
Site 82
T929
S
Q
T
S
P
T
V
T
Y
D
S
N
L
K
V
Site 83
Y967
D
E
E
K
I
D
C
Y
P
D
E
N
G
A
S
Site 84
S974
Y
P
D
E
N
G
A
S
A
E
N
C
T
A
R
Site 85
S988
R
G
C
I
W
E
A
S
N
S
S
G
V
P
F
Site 86
S1006
V
N
D
L
Y
S
V
S
D
V
Q
Y
N
S
H
Site 87
Y1010
Y
S
V
S
D
V
Q
Y
N
S
H
G
A
T
A
Site 88
T1016
Q
Y
N
S
H
G
A
T
A
D
I
S
L
K
S
Site 89
S1020
H
G
A
T
A
D
I
S
L
K
S
S
V
Y
A
Site 90
S1032
V
Y
A
N
A
F
P
S
T
P
V
N
P
L
R
Site 91
T1033
Y
A
N
A
F
P
S
T
P
V
N
P
L
R
L
Site 92
T1043
N
P
L
R
L
D
V
T
Y
H
K
N
E
M
L
Site 93
Y1044
P
L
R
L
D
V
T
Y
H
K
N
E
M
L
Q
Site 94
Y1055
E
M
L
Q
F
K
I
Y
D
P
N
K
N
R
Y
Site 95
Y1062
Y
D
P
N
K
N
R
Y
E
V
P
V
P
L
N
Site 96
S1072
P
V
P
L
N
I
P
S
M
P
S
S
T
P
E
Site 97
S1076
N
I
P
S
M
P
S
S
T
P
E
G
Q
L
Y
Site 98
T1077
I
P
S
M
P
S
S
T
P
E
G
Q
L
Y
D
Site 99
Y1083
S
T
P
E
G
Q
L
Y
D
V
L
I
K
K
N
Site 100
S1100
G
I
E
I
R
R
K
S
T
G
T
I
I
W
D
Site 101
T1101
I
E
I
R
R
K
S
T
G
T
I
I
W
D
S
Site 102
T1103
I
R
R
K
S
T
G
T
I
I
W
D
S
Q
L
Site 103
S1123
S
D
M
F
I
R
I
S
T
R
L
P
S
K
Y
Site 104
T1124
D
M
F
I
R
I
S
T
R
L
P
S
K
Y
L
Site 105
S1128
R
I
S
T
R
L
P
S
K
Y
L
Y
G
F
G
Site 106
Y1130
S
T
R
L
P
S
K
Y
L
Y
G
F
G
E
T
Site 107
Y1132
R
L
P
S
K
Y
L
Y
G
F
G
E
T
E
H
Site 108
S1141
F
G
E
T
E
H
R
S
Y
R
R
D
L
E
W
Site 109
Y1142
G
E
T
E
H
R
S
Y
R
R
D
L
E
W
H
Site 110
Y1162
S
R
D
Q
P
P
G
Y
K
K
N
S
Y
G
V
Site 111
Y1167
P
G
Y
K
K
N
S
Y
G
V
H
P
Y
Y
M
Site 112
Y1173
S
Y
G
V
H
P
Y
Y
M
G
L
E
E
D
G
Site 113
Y1229
P
E
L
V
T
Q
Q
Y
T
E
L
I
G
R
P
Site 114
Y1251
L
G
F
Q
L
C
R
Y
G
Y
Q
N
D
S
E
Site 115
Y1253
F
Q
L
C
R
Y
G
Y
Q
N
D
S
E
I
A
Site 116
S1257
R
Y
G
Y
Q
N
D
S
E
I
A
S
L
Y
D
Site 117
S1261
Q
N
D
S
E
I
A
S
L
Y
D
E
M
V
A
Site 118
Y1263
D
S
E
I
A
S
L
Y
D
E
M
V
A
A
Q
Site 119
Y1277
Q
I
P
Y
D
V
Q
Y
S
D
I
D
Y
M
E
Site 120
Y1282
V
Q
Y
S
D
I
D
Y
M
E
R
Q
L
D
F
Site 121
T1290
M
E
R
Q
L
D
F
T
L
S
P
K
F
A
G
Site 122
S1292
R
Q
L
D
F
T
L
S
P
K
F
A
G
F
P
Site 123
S1321
L
I
L
D
P
A
I
S
G
N
E
T
Q
P
Y
Site 124
T1325
P
A
I
S
G
N
E
T
Q
P
Y
P
A
F
T
Site 125
Y1328
S
G
N
E
T
Q
P
Y
P
A
F
T
R
G
V
Site 126
Y1343
E
D
D
V
F
I
K
Y
P
N
D
G
D
I
V
Site 127
S1366
P
D
V
V
V
N
G
S
L
D
W
D
S
Q
V
Site 128
S1371
N
G
S
L
D
W
D
S
Q
V
E
L
Y
R
A
Site 129
Y1402
K
R
E
I
E
E
L
Y
N
N
P
Q
N
P
E
Site 130
S1426
I
D
M
N
E
P
S
S
F
V
N
G
A
V
S
Site 131
S1433
S
F
V
N
G
A
V
S
P
G
C
R
D
A
S
Site 132
S1440
S
P
G
C
R
D
A
S
L
N
H
P
P
Y
M
Site 133
Y1446
A
S
L
N
H
P
P
Y
M
P
H
L
E
S
R
Site 134
S1452
P
Y
M
P
H
L
E
S
R
D
R
G
L
S
S
Site 135
S1458
E
S
R
D
R
G
L
S
S
K
T
L
C
M
E
Site 136
S1459
S
R
D
R
G
L
S
S
K
T
L
C
M
E
S
Site 137
T1461
D
R
G
L
S
S
K
T
L
C
M
E
S
Q
Q
Site 138
S1466
S
K
T
L
C
M
E
S
Q
Q
I
L
P
D
G
Site 139
S1474
Q
Q
I
L
P
D
G
S
L
V
Q
H
Y
N
V
Site 140
Y1479
D
G
S
L
V
Q
H
Y
N
V
H
N
L
Y
G
Site 141
Y1485
H
Y
N
V
H
N
L
Y
G
W
S
Q
T
R
P
Site 142
T1493
G
W
S
Q
T
R
P
T
Y
E
A
V
Q
E
V
Site 143
Y1494
W
S
Q
T
R
P
T
Y
E
A
V
Q
E
V
T
Site 144
T1509
G
Q
R
G
V
V
I
T
R
S
T
F
P
S
S
Site 145
S1511
R
G
V
V
I
T
R
S
T
F
P
S
S
G
R
Site 146
T1512
G
V
V
I
T
R
S
T
F
P
S
S
G
R
W
Site 147
S1515
I
T
R
S
T
F
P
S
S
G
R
W
A
G
H
Site 148
S1516
T
R
S
T
F
P
S
S
G
R
W
A
G
H
W
Site 149
S1596
T
R
R
Q
D
P
V
S
W
D
V
A
F
V
N
Site 150
T1607
A
F
V
N
I
S
R
T
V
L
Q
T
R
Y
T
Site 151
T1611
I
S
R
T
V
L
Q
T
R
Y
T
L
L
P
Y
Site 152
Y1613
R
T
V
L
Q
T
R
Y
T
L
L
P
Y
L
Y
Site 153
Y1618
T
R
Y
T
L
L
P
Y
L
Y
T
L
M
H
K
Site 154
Y1620
Y
T
L
L
P
Y
L
Y
T
L
M
H
K
A
H
Site 155
T1621
T
L
L
P
Y
L
Y
T
L
M
H
K
A
H
T
Site 156
T1632
K
A
H
T
E
G
V
T
V
V
R
P
L
L
H
Site 157
T1647
E
F
V
S
D
Q
V
T
W
D
I
D
S
Q
F
Site 158
T1674
E
R
N
A
R
N
V
T
A
Y
F
P
R
A
R
Site 159
Y1676
N
A
R
N
V
T
A
Y
F
P
R
A
R
W
Y
Site 160
Y1683
Y
F
P
R
A
R
W
Y
D
Y
Y
T
G
V
D
Site 161
Y1685
P
R
A
R
W
Y
D
Y
Y
T
G
V
D
I
N
Site 162
Y1686
R
A
R
W
Y
D
Y
Y
T
G
V
D
I
N
A
Site 163
T1687
A
R
W
Y
D
Y
Y
T
G
V
D
I
N
A
R
Site 164
T1699
N
A
R
G
E
W
K
T
L
P
A
P
L
D
H
Site 165
Y1715
N
L
H
V
R
G
G
Y
I
L
P
W
Q
E
P
Site 166
S1729
P
A
L
N
T
H
L
S
R
Q
K
F
M
G
F
Site 167
T1760
D
D
G
Q
S
I
D
T
Y
G
K
G
L
Y
Y
Site 168
Y1761
D
G
Q
S
I
D
T
Y
G
K
G
L
Y
Y
L
Site 169
Y1766
D
T
Y
G
K
G
L
Y
Y
L
A
S
F
S
A
Site 170
Y1767
T
Y
G
K
G
L
Y
Y
L
A
S
F
S
A
S
Site 171
S1770
K
G
L
Y
Y
L
A
S
F
S
A
S
Q
N
T
Site 172
S1772
L
Y
Y
L
A
S
F
S
A
S
Q
N
T
M
Q
Site 173
S1774
Y
L
A
S
F
S
A
S
Q
N
T
M
Q
S
H
Site 174
Y1787
S
H
I
I
F
N
N
Y
I
T
G
T
N
P
L
Site 175
T1822
S
V
S
G
M
V
I
T
P
S
F
N
N
D
P
Site 176
S1824
S
G
M
V
I
T
P
S
F
N
N
D
P
T
T
Site 177
T1830
P
S
F
N
N
D
P
T
T
Q
V
L
S
I
D
Site 178
T1831
S
F
N
N
D
P
T
T
Q
V
L
S
I
D
V
Site 179
T1839
Q
V
L
S
I
D
V
T
D
R
N
I
S
L
H
Site 180
S1844
D
V
T
D
R
N
I
S
L
H
N
F
T
S
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation