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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SUV39H1
Full Name:
Histone-lysine N-methyltransferase SUV39H1
Alias:
H3-K9-HMTase 1; Histone H3-K9 methyltransferase 1; Histone-lysine N-methyltransferase, H3 lysine-9 specific 1; KMT1A; Suppressor of variegation 3-9; suppressor of variegation 3-9 1; SUV39H; SUV91
Type:
Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; Methyltransferase
Mass (Da):
47907
Number AA:
412
UniProt ID:
O43463
International Prot ID:
IPI00156887
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000785
GO:0000775
GO:0000794
Uniprot
OncoNet
Molecular Function:
GO:0003682
GO:0046974
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007049
GO:0030154
GO:0006333
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S36
S
C
P
A
L
G
I
S
K
R
N
L
Y
D
F
Site 2
Y41
G
I
S
K
R
N
L
Y
D
F
E
V
E
Y
L
Site 3
Y47
L
Y
D
F
E
V
E
Y
L
C
D
Y
K
K
I
Site 4
Y51
E
V
E
Y
L
C
D
Y
K
K
I
R
E
Q
E
Site 5
Y59
K
K
I
R
E
Q
E
Y
Y
L
V
K
W
R
G
Site 6
Y60
K
I
R
E
Q
E
Y
Y
L
V
K
W
R
G
Y
Site 7
Y67
Y
L
V
K
W
R
G
Y
P
D
S
E
S
T
W
Site 8
S70
K
W
R
G
Y
P
D
S
E
S
T
W
E
P
R
Site 9
S72
R
G
Y
P
D
S
E
S
T
W
E
P
R
Q
N
Site 10
S104
L
L
R
R
H
H
R
S
K
T
P
R
H
L
D
Site 11
T106
R
R
H
H
R
S
K
T
P
R
H
L
D
P
S
Site 12
S113
T
P
R
H
L
D
P
S
L
A
N
Y
L
V
Q
Site 13
Y117
L
D
P
S
L
A
N
Y
L
V
Q
K
A
K
Q
Site 14
S140
Q
E
L
N
A
K
R
S
H
L
G
R
I
T
V
Site 15
T146
R
S
H
L
G
R
I
T
V
E
N
E
V
D
L
Site 16
Y205
A
S
L
H
K
F
A
Y
N
D
Q
G
Q
V
R
Site 17
Y220
L
R
A
G
L
P
I
Y
E
C
N
S
R
C
R
Site 18
Y230
N
S
R
C
R
C
G
Y
D
C
P
N
R
V
V
Site 19
T260
G
R
G
W
G
V
R
T
L
E
K
I
R
K
N
Site 20
S268
L
E
K
I
R
K
N
S
F
V
M
E
Y
V
G
Site 21
S280
Y
V
G
E
I
I
T
S
E
E
A
E
R
R
G
Site 22
Y290
A
E
R
R
G
Q
I
Y
D
R
Q
G
A
T
Y
Site 23
Y297
Y
D
R
Q
G
A
T
Y
L
F
D
L
D
Y
V
Site 24
Y308
L
D
Y
V
E
D
V
Y
T
V
D
A
A
Y
Y
Site 25
T309
D
Y
V
E
D
V
Y
T
V
D
A
A
Y
Y
G
Site 26
T362
I
R
A
G
E
E
L
T
F
D
Y
N
M
Q
V
Site 27
Y365
G
E
E
L
T
F
D
Y
N
M
Q
V
D
P
V
Site 28
S376
V
D
P
V
D
M
E
S
T
R
M
D
S
N
F
Site 29
S381
M
E
S
T
R
M
D
S
N
F
G
L
A
G
L
Site 30
S391
G
L
A
G
L
P
G
S
P
K
K
R
V
R
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation