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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HtrA2
Full Name:
Serine protease HTRA2, mitochondrial
Alias:
EC 3.4.21.108; High temperature requirement protein A2; OMI; Omi stress-regulated endoprotease; PRSS25; Serine protease 25; Serine proteinase OMI
Type:
Uncharacterized protein
Mass (Da):
48841
Number AA:
458
UniProt ID:
O43464
International Prot ID:
Isoform1 - IPI00001665
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005789
GO:0016021
GO:0005758
Uniprot
OncoNet
Molecular Function:
GO:0004252
GO:0051082
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
GO:0006508
GO:0006950
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
A
G
R
G
A
G
W
S
L
R
A
W
R
A
L
Site 2
T32
W
G
R
R
P
R
L
T
P
D
L
R
A
L
L
Site 3
T40
P
D
L
R
A
L
L
T
S
G
T
S
D
P
R
Site 4
S41
D
L
R
A
L
L
T
S
G
T
S
D
P
R
A
Site 5
T43
R
A
L
L
T
S
G
T
S
D
P
R
A
R
V
Site 6
S44
A
L
L
T
S
G
T
S
D
P
R
A
R
V
T
Site 7
T51
S
D
P
R
A
R
V
T
Y
G
T
P
S
L
W
Site 8
Y52
D
P
R
A
R
V
T
Y
G
T
P
S
L
W
A
Site 9
T54
R
A
R
V
T
Y
G
T
P
S
L
W
A
R
L
Site 10
S56
R
V
T
Y
G
T
P
S
L
W
A
R
L
S
V
Site 11
S62
P
S
L
W
A
R
L
S
V
G
V
T
E
P
R
Site 12
S74
E
P
R
A
C
L
T
S
G
T
P
G
P
R
A
Site 13
T76
R
A
C
L
T
S
G
T
P
G
P
R
A
Q
L
Site 14
T84
P
G
P
R
A
Q
L
T
A
V
T
P
D
T
R
Site 15
T87
R
A
Q
L
T
A
V
T
P
D
T
R
T
R
E
Site 16
T90
L
T
A
V
T
P
D
T
R
T
R
E
A
S
E
Site 17
T92
A
V
T
P
D
T
R
T
R
E
A
S
E
N
S
Site 18
S96
D
T
R
T
R
E
A
S
E
N
S
G
T
R
S
Site 19
S99
T
R
E
A
S
E
N
S
G
T
R
S
R
A
W
Site 20
T101
E
A
S
E
N
S
G
T
R
S
R
A
W
L
A
Site 21
S103
S
E
N
S
G
T
R
S
R
A
W
L
A
V
A
Site 22
S142
V
P
S
P
P
P
A
S
P
R
S
Q
Y
N
F
Site 23
S145
P
P
P
A
S
P
R
S
Q
Y
N
F
I
A
D
Site 24
Y147
P
A
S
P
R
S
Q
Y
N
F
I
A
D
V
V
Site 25
S212
R
V
R
V
R
L
L
S
G
D
T
Y
E
A
V
Site 26
T231
D
P
V
A
D
I
A
T
L
R
I
Q
T
K
E
Site 27
T242
Q
T
K
E
P
L
P
T
L
P
L
G
R
S
A
Site 28
S248
P
T
L
P
L
G
R
S
A
D
V
R
Q
G
E
Site 29
S276
T
I
T
S
G
I
V
S
S
A
Q
R
P
A
R
Site 30
S277
I
T
S
G
I
V
S
S
A
Q
R
P
A
R
D
Site 31
T290
R
D
L
G
L
P
Q
T
N
V
E
Y
I
Q
T
Site 32
T297
T
N
V
E
Y
I
Q
T
D
A
A
I
D
F
G
Site 33
S350
H
R
G
E
K
K
N
S
S
S
G
I
S
G
S
Site 34
S351
R
G
E
K
K
N
S
S
S
G
I
S
G
S
Q
Site 35
S352
G
E
K
K
N
S
S
S
G
I
S
G
S
Q
R
Site 36
S355
K
N
S
S
S
G
I
S
G
S
Q
R
R
Y
I
Site 37
S357
S
S
S
G
I
S
G
S
Q
R
R
Y
I
G
V
Site 38
Y361
I
S
G
S
Q
R
R
Y
I
G
V
M
M
L
T
Site 39
S383
E
L
Q
L
R
E
P
S
F
P
D
V
Q
H
G
Site 40
S400
I
H
K
V
I
L
G
S
P
A
H
R
A
G
L
Site 41
Y428
V
Q
N
A
E
D
V
Y
E
A
V
R
T
Q
S
Site 42
T433
D
V
Y
E
A
V
R
T
Q
S
Q
L
A
V
Q
Site 43
S435
Y
E
A
V
R
T
Q
S
Q
L
A
V
Q
I
R
Site 44
T447
Q
I
R
R
G
R
E
T
L
T
L
Y
V
T
P
Site 45
T449
R
R
G
R
E
T
L
T
L
Y
V
T
P
E
V
Site 46
Y451
G
R
E
T
L
T
L
Y
V
T
P
E
V
T
E
Site 47
T453
E
T
L
T
L
Y
V
T
P
E
V
T
E
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation