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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EPB41L2
Full Name:
Band 4.1-like protein 2
Alias:
4.1G; 4.1-G; E41L2; E4L2; Erythrocyte membrane protein band 4.1-like 2; Generally expressed protein 4.1
Type:
Cytoskeletal protein
Mass (Da):
112588
Number AA:
1005
UniProt ID:
O43491
International Prot ID:
IPI00015973
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0019898
GO:0005886
GO:0008091
Uniprot
OncoNet
Molecular Function:
GO:0003779
GO:0005198
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0030866
GO:0007010
GO:0009987
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
T
T
E
V
G
S
V
S
E
V
K
K
D
S
S
Site 2
S15
V
S
E
V
K
K
D
S
S
Q
L
G
T
D
A
Site 3
S16
S
E
V
K
K
D
S
S
Q
L
G
T
D
A
T
Site 4
T20
K
D
S
S
Q
L
G
T
D
A
T
K
E
K
P
Site 5
T23
S
Q
L
G
T
D
A
T
K
E
K
P
K
E
V
Site 6
S38
A
E
N
Q
Q
N
Q
S
S
D
P
E
E
E
K
Site 7
S39
E
N
Q
Q
N
Q
S
S
D
P
E
E
E
K
G
Site 8
S47
D
P
E
E
E
K
G
S
Q
P
P
P
A
A
E
Site 9
S55
Q
P
P
P
A
A
E
S
Q
S
S
L
R
R
Q
Site 10
S57
P
P
A
A
E
S
Q
S
S
L
R
R
Q
K
R
Site 11
S58
P
A
A
E
S
Q
S
S
L
R
R
Q
K
R
E
Site 12
S69
Q
K
R
E
K
E
T
S
E
S
R
G
I
S
R
Site 13
S71
R
E
K
E
T
S
E
S
R
G
I
S
R
F
I
Site 14
S75
T
S
E
S
R
G
I
S
R
F
I
P
P
W
L
Site 15
S87
P
W
L
K
K
Q
K
S
Y
T
L
V
V
A
K
Site 16
Y88
W
L
K
K
Q
K
S
Y
T
L
V
V
A
K
D
Site 17
T89
L
K
K
Q
K
S
Y
T
L
V
V
A
K
D
G
Site 18
T103
G
G
D
K
K
E
P
T
Q
A
V
V
E
E
Q
Site 19
S149
E
V
K
E
E
K
P
S
V
S
K
E
E
K
P
Site 20
S151
K
E
E
K
P
S
V
S
K
E
E
K
P
S
V
Site 21
S157
V
S
K
E
E
K
P
S
V
S
K
V
E
M
Q
Site 22
S159
K
E
E
K
P
S
V
S
K
V
E
M
Q
P
T
Site 23
T166
S
K
V
E
M
Q
P
T
E
L
V
S
K
E
R
Site 24
T194
G
G
A
A
K
R
E
T
K
E
V
Q
T
N
E
Site 25
S208
E
L
K
A
E
K
A
S
Q
K
V
T
K
K
T
Site 26
T212
E
K
A
S
Q
K
V
T
K
K
T
K
T
V
Q
Site 27
T217
K
V
T
K
K
T
K
T
V
Q
C
K
V
T
L
Site 28
Y230
T
L
L
D
G
T
E
Y
S
C
D
L
E
K
H
Site 29
S231
L
L
D
G
T
E
Y
S
C
D
L
E
K
H
A
Site 30
S266
F
G
L
L
F
Q
E
S
P
E
Q
K
N
W
L
Site 31
Y297
F
T
F
N
V
K
F
Y
P
P
D
P
S
Q
L
Site 32
S302
K
F
Y
P
P
D
P
S
Q
L
T
E
D
I
T
Site 33
T305
P
P
D
P
S
Q
L
T
E
D
I
T
R
Y
F
Site 34
T309
S
Q
L
T
E
D
I
T
R
Y
F
L
C
L
Q
Site 35
S323
Q
L
R
Q
D
I
A
S
G
R
L
P
C
S
F
Site 36
Y348
L
Q
A
E
L
G
D
Y
D
P
E
E
H
G
S
Site 37
S355
Y
D
P
E
E
H
G
S
I
D
L
S
E
F
Q
Site 38
S359
E
H
G
S
I
D
L
S
E
F
Q
F
A
P
T
Site 39
T381
K
V
A
E
L
H
K
T
H
R
G
L
S
P
A
Site 40
S386
H
K
T
H
R
G
L
S
P
A
Q
A
D
S
Q
Site 41
S392
L
S
P
A
Q
A
D
S
Q
F
L
E
N
A
K
Site 42
S402
L
E
N
A
K
R
L
S
M
Y
G
V
D
L
H
Site 43
Y404
N
A
K
R
L
S
M
Y
G
V
D
L
H
H
A
Site 44
S449
W
P
K
I
L
K
I
S
Y
K
R
S
N
F
Y
Site 45
Y450
P
K
I
L
K
I
S
Y
K
R
S
N
F
Y
I
Site 46
S453
L
K
I
S
Y
K
R
S
N
F
Y
I
K
V
R
Site 47
Y456
S
Y
K
R
S
N
F
Y
I
K
V
R
P
A
E
Site 48
S469
A
E
L
E
Q
F
E
S
T
I
G
F
K
L
P
Site 49
T493
K
V
C
V
E
H
H
T
F
Y
R
L
V
S
P
Site 50
Y495
C
V
E
H
H
T
F
Y
R
L
V
S
P
E
Q
Site 51
S499
H
T
F
Y
R
L
V
S
P
E
Q
P
P
K
A
Site 52
T510
P
P
K
A
K
F
L
T
L
G
S
K
F
R
Y
Site 53
S513
A
K
F
L
T
L
G
S
K
F
R
Y
S
G
R
Site 54
Y517
T
L
G
S
K
F
R
Y
S
G
R
T
Q
A
Q
Site 55
S518
L
G
S
K
F
R
Y
S
G
R
T
Q
A
Q
T
Site 56
T521
K
F
R
Y
S
G
R
T
Q
A
Q
T
R
Q
A
Site 57
T525
S
G
R
T
Q
A
Q
T
R
Q
A
S
T
L
I
Site 58
S529
Q
A
Q
T
R
Q
A
S
T
L
I
D
R
P
A
Site 59
S543
A
P
H
F
E
R
T
S
S
K
R
V
S
R
S
Site 60
S544
P
H
F
E
R
T
S
S
K
R
V
S
R
S
L
Site 61
S548
R
T
S
S
K
R
V
S
R
S
L
D
G
A
P
Site 62
S550
S
S
K
R
V
S
R
S
L
D
G
A
P
I
G
Site 63
S562
P
I
G
V
M
D
Q
S
L
M
K
D
F
P
G
Site 64
S575
P
G
A
A
G
E
I
S
A
Y
G
P
G
L
V
Site 65
Y577
A
A
G
E
I
S
A
Y
G
P
G
L
V
S
I
Site 66
S598
D
G
R
R
E
V
R
S
P
T
K
A
P
H
L
Site 67
T600
R
R
E
V
R
S
P
T
K
A
P
H
L
Q
L
Site 68
S614
L
I
E
G
K
K
N
S
L
R
V
E
G
D
N
Site 69
Y623
R
V
E
G
D
N
I
Y
V
R
H
S
N
L
M
Site 70
S627
D
N
I
Y
V
R
H
S
N
L
M
L
E
E
L
Site 71
S647
D
I
L
K
H
Q
A
S
I
S
E
L
K
R
N
Site 72
S649
L
K
H
Q
A
S
I
S
E
L
K
R
N
F
M
Site 73
S658
L
K
R
N
F
M
E
S
T
P
E
P
R
P
N
Site 74
T659
K
R
N
F
M
E
S
T
P
E
P
R
P
N
E
Site 75
T673
E
W
E
K
R
R
I
T
P
L
S
L
Q
T
Q
Site 76
S676
K
R
R
I
T
P
L
S
L
Q
T
Q
G
S
S
Site 77
T679
I
T
P
L
S
L
Q
T
Q
G
S
S
H
E
T
Site 78
S682
L
S
L
Q
T
Q
G
S
S
H
E
T
L
N
I
Site 79
S683
S
L
Q
T
Q
G
S
S
H
E
T
L
N
I
V
Site 80
T686
T
Q
G
S
S
H
E
T
L
N
I
V
E
E
K
Site 81
T706
G
K
D
E
R
V
I
T
E
E
M
N
G
K
E
Site 82
S715
E
M
N
G
K
E
I
S
P
G
S
G
P
G
E
Site 83
S718
G
K
E
I
S
P
G
S
G
P
G
E
I
R
K
Site 84
T730
I
R
K
V
E
P
V
T
Q
K
D
S
T
S
L
Site 85
S734
E
P
V
T
Q
K
D
S
T
S
L
S
S
E
S
Site 86
T735
P
V
T
Q
K
D
S
T
S
L
S
S
E
S
S
Site 87
S736
V
T
Q
K
D
S
T
S
L
S
S
E
S
S
S
Site 88
S738
Q
K
D
S
T
S
L
S
S
E
S
S
S
S
S
Site 89
S739
K
D
S
T
S
L
S
S
E
S
S
S
S
S
S
Site 90
S741
S
T
S
L
S
S
E
S
S
S
S
S
S
E
S
Site 91
S742
T
S
L
S
S
E
S
S
S
S
S
S
E
S
E
Site 92
S743
S
L
S
S
E
S
S
S
S
S
S
E
S
E
E
Site 93
S744
L
S
S
E
S
S
S
S
S
S
E
S
E
E
E
Site 94
S745
S
S
E
S
S
S
S
S
S
E
S
E
E
E
D
Site 95
S746
S
E
S
S
S
S
S
S
E
S
E
E
E
D
V
Site 96
S748
S
S
S
S
S
S
E
S
E
E
E
D
V
G
E
Site 97
T763
Y
R
P
H
H
R
V
T
E
G
T
I
R
E
E
Site 98
T766
H
H
R
V
T
E
G
T
I
R
E
E
Q
E
Y
Site 99
Y773
T
I
R
E
E
Q
E
Y
E
E
E
V
E
E
E
Site 100
S798
E
E
A
V
P
E
A
S
P
V
T
Q
A
G
A
Site 101
S806
P
V
T
Q
A
G
A
S
V
I
T
V
E
T
V
Site 102
S828
Q
K
I
P
G
E
K
S
V
H
E
G
A
L
K
Site 103
T875
S
E
P
P
V
V
K
T
E
M
V
T
I
S
D
Site 104
S881
K
T
E
M
V
T
I
S
D
A
S
Q
R
T
E
Site 105
S884
M
V
T
I
S
D
A
S
Q
R
T
E
I
S
T
Site 106
S890
A
S
Q
R
T
E
I
S
T
K
E
V
P
I
V
Site 107
T891
S
Q
R
T
E
I
S
T
K
E
V
P
I
V
Q
Site 108
Y906
T
E
T
K
T
I
T
Y
E
S
P
Q
I
D
G
Site 109
S908
T
K
T
I
T
Y
E
S
P
Q
I
D
G
G
A
Site 110
S919
D
G
G
A
G
G
D
S
G
T
L
L
T
A
Q
Site 111
S930
L
T
A
Q
T
I
T
S
E
S
V
S
T
T
T
Site 112
S932
A
Q
T
I
T
S
E
S
V
S
T
T
T
T
T
Site 113
S934
T
I
T
S
E
S
V
S
T
T
T
T
T
H
I
Site 114
T936
T
S
E
S
V
S
T
T
T
T
T
H
I
T
K
Site 115
T938
E
S
V
S
T
T
T
T
T
H
I
T
K
T
V
Site 116
T944
T
T
T
H
I
T
K
T
V
K
G
G
I
S
E
Site 117
S950
K
T
V
K
G
G
I
S
E
T
R
I
E
K
R
Site 118
S987
R
E
Q
H
P
D
M
S
V
T
R
V
V
V
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation