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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CACNA1G
Full Name:
Voltage-dependent T-type calcium channel subunit alpha-1G
Alias:
Ca(V)T.1; CAC1G; Calcium channel, voltage-dependent, T type, alpha 1G; Calcium channel, voltage-dependent, T type, alpha 1G subunit; Cav3.1; Cav3.1c; NBR13; Voltage-dependent T-type calcium channel alpha-1G; Voltage-gated calcium channel alpha Cav3.1; Voltage-gated calcium channel subunit alpha Cav3.1
Type:
Mass (Da):
262453
Number AA:
2377
UniProt ID:
O43497
International Prot ID:
IPI00218687
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005891
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0008332
PhosphoSite+
KinaseNET
Biological Process:
GO:0006816
GO:0055085
Phosida
TranscriptoNet
STRING
Kinexus Products
Voltage-dependent T-type calcium channel subunit alpha-1G pan-specific antibody AB-NN227-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN227-1
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
D
G
A
G
A
E
E
S
G
Q
P
R
S
F
M
Site 2
S18
E
E
S
G
Q
P
R
S
F
M
R
L
N
D
L
Site 3
S26
F
M
R
L
N
D
L
S
G
A
G
G
R
P
G
Site 4
S36
G
G
R
P
G
P
G
S
A
E
K
D
P
G
S
Site 5
S43
S
A
E
K
D
P
G
S
A
D
S
E
A
E
G
Site 6
S46
K
D
P
G
S
A
D
S
E
A
E
G
L
P
Y
Site 7
S65
P
V
V
F
F
Y
L
S
Q
D
S
R
P
R
S
Site 8
S68
F
F
Y
L
S
Q
D
S
R
P
R
S
W
C
L
Site 9
S72
S
Q
D
S
R
P
R
S
W
C
L
R
T
V
C
Site 10
Y147
G
I
F
G
K
K
C
Y
L
G
D
T
W
N
R
Site 11
S252
E
N
F
S
L
P
L
S
V
D
L
E
R
Y
Y
Site 12
Y259
S
V
D
L
E
R
Y
Y
Q
T
E
N
E
D
E
Site 13
S267
Q
T
E
N
E
D
E
S
P
F
I
C
S
Q
P
Site 14
S272
D
E
S
P
F
I
C
S
Q
P
R
E
N
G
M
Site 15
S281
P
R
E
N
G
M
R
S
C
R
S
V
P
T
L
Site 16
S284
N
G
M
R
S
C
R
S
V
P
T
L
R
G
D
Site 17
T287
R
S
C
R
S
V
P
T
L
R
G
D
G
G
G
Site 18
Y302
G
P
P
C
G
L
D
Y
E
A
Y
N
S
S
S
Site 19
Y305
C
G
L
D
Y
E
A
Y
N
S
S
S
N
T
T
Site 20
S307
L
D
Y
E
A
Y
N
S
S
S
N
T
T
C
V
Site 21
S406
S
E
T
K
Q
R
E
S
Q
L
M
R
E
Q
R
Site 22
S418
E
Q
R
V
R
F
L
S
N
A
S
T
L
A
S
Site 23
S421
V
R
F
L
S
N
A
S
T
L
A
S
F
S
E
Site 24
T422
R
F
L
S
N
A
S
T
L
A
S
F
S
E
P
Site 25
S425
S
N
A
S
T
L
A
S
F
S
E
P
G
S
C
Site 26
S427
A
S
T
L
A
S
F
S
E
P
G
S
C
Y
E
Site 27
S431
A
S
F
S
E
P
G
S
C
Y
E
E
L
L
K
Site 28
Y433
F
S
E
P
G
S
C
Y
E
E
L
L
K
Y
L
Site 29
S455
A
R
R
L
A
Q
V
S
R
A
A
G
V
R
V
Site 30
S466
G
V
R
V
G
L
L
S
S
P
A
P
L
G
G
Site 31
S467
V
R
V
G
L
L
S
S
P
A
P
L
G
G
Q
Site 32
T476
A
P
L
G
G
Q
E
T
Q
P
S
S
S
C
S
Site 33
S479
G
G
Q
E
T
Q
P
S
S
S
C
S
R
S
H
Site 34
S480
G
Q
E
T
Q
P
S
S
S
C
S
R
S
H
R
Site 35
S481
Q
E
T
Q
P
S
S
S
C
S
R
S
H
R
R
Site 36
S483
T
Q
P
S
S
S
C
S
R
S
H
R
R
L
S
Site 37
S485
P
S
S
S
C
S
R
S
H
R
R
L
S
V
H
Site 38
S490
S
R
S
H
R
R
L
S
V
H
H
L
V
H
H
Site 39
T511
H
Y
H
L
G
N
G
T
L
R
A
P
R
A
S
Site 40
S518
T
L
R
A
P
R
A
S
P
E
I
Q
D
R
D
Site 41
S529
Q
D
R
D
A
N
G
S
R
R
L
M
L
P
P
Site 42
S543
P
P
S
T
P
A
L
S
G
A
P
P
G
G
A
Site 43
S552
A
P
P
G
G
A
E
S
V
H
S
F
Y
H
A
Site 44
S575
C
Q
A
P
P
P
R
S
P
S
E
A
S
G
R
Site 45
S577
A
P
P
P
R
S
P
S
E
A
S
G
R
T
V
Site 46
S580
P
R
S
P
S
E
A
S
G
R
T
V
G
S
G
Site 47
T583
P
S
E
A
S
G
R
T
V
G
S
G
K
V
Y
Site 48
Y590
T
V
G
S
G
K
V
Y
P
T
V
H
T
S
P
Site 49
T592
G
S
G
K
V
Y
P
T
V
H
T
S
P
P
P
Site 50
S596
V
Y
P
T
V
H
T
S
P
P
P
E
T
L
K
Site 51
T620
S
S
G
P
P
T
L
T
S
L
N
I
P
P
G
Site 52
S621
S
G
P
P
T
L
T
S
L
N
I
P
P
G
P
Site 53
S630
N
I
P
P
G
P
Y
S
S
M
H
K
L
L
E
Site 54
S631
I
P
P
G
P
Y
S
S
M
H
K
L
L
E
T
Site 55
T638
S
M
H
K
L
L
E
T
Q
S
T
G
A
C
Q
Site 56
S640
H
K
L
L
E
T
Q
S
T
G
A
C
Q
S
S
Site 57
T641
K
L
L
E
T
Q
S
T
G
A
C
Q
S
S
C
Site 58
S646
Q
S
T
G
A
C
Q
S
S
C
K
I
S
S
P
Site 59
S647
S
T
G
A
C
Q
S
S
C
K
I
S
S
P
C
Site 60
S651
C
Q
S
S
C
K
I
S
S
P
C
L
K
A
D
Site 61
S652
Q
S
S
C
K
I
S
S
P
C
L
K
A
D
S
Site 62
S659
S
P
C
L
K
A
D
S
G
A
C
G
P
D
S
Site 63
S666
S
G
A
C
G
P
D
S
C
P
Y
C
A
R
A
Site 64
Y669
C
G
P
D
S
C
P
Y
C
A
R
A
G
A
G
Site 65
S688
A
D
R
E
M
P
D
S
D
S
E
A
V
Y
E
Site 66
S690
R
E
M
P
D
S
D
S
E
A
V
Y
E
F
T
Site 67
Y694
D
S
D
S
E
A
V
Y
E
F
T
Q
D
A
Q
Site 68
S703
F
T
Q
D
A
Q
H
S
D
L
R
D
P
H
S
Site 69
S710
S
D
L
R
D
P
H
S
R
R
Q
R
S
L
G
Site 70
S715
P
H
S
R
R
Q
R
S
L
G
P
D
A
E
P
Site 71
S723
L
G
P
D
A
E
P
S
S
V
L
A
F
W
R
Site 72
S724
G
P
D
A
E
P
S
S
V
L
A
F
W
R
L
Site 73
T735
F
W
R
L
I
C
D
T
F
R
K
I
V
D
S
Site 74
S742
T
F
R
K
I
V
D
S
K
Y
F
G
R
G
I
Site 75
Y744
R
K
I
V
D
S
K
Y
F
G
R
G
I
M
I
Site 76
S831
G
Q
Q
G
G
G
L
S
V
L
R
T
F
R
L
Site 77
S893
L
F
G
C
K
F
A
S
E
R
D
G
D
T
L
Site 78
T899
A
S
E
R
D
G
D
T
L
P
D
R
K
N
F
Site 79
S908
P
D
R
K
N
F
D
S
L
L
W
A
I
V
T
Site 80
Y930
E
D
W
N
K
V
L
Y
N
G
M
A
S
T
S
Site 81
S973
G
F
Q
A
E
E
I
S
K
R
E
D
A
S
G
Site 82
S979
I
S
K
R
E
D
A
S
G
Q
L
S
C
I
Q
Site 83
S983
E
D
A
S
G
Q
L
S
C
I
Q
L
P
V
D
Site 84
S991
C
I
Q
L
P
V
D
S
Q
G
G
D
A
N
K
Site 85
S999
Q
G
G
D
A
N
K
S
E
S
E
P
D
F
F
Site 86
S1001
G
D
A
N
K
S
E
S
E
P
D
F
F
S
P
Site 87
S1007
E
S
E
P
D
F
F
S
P
S
L
D
G
D
G
Site 88
S1009
E
P
D
F
F
S
P
S
L
D
G
D
G
D
R
Site 89
S1034
E
H
P
E
L
R
K
S
L
L
P
P
L
I
I
Site 90
S1049
H
T
A
A
T
P
M
S
L
P
K
S
T
S
T
Site 91
S1053
T
P
M
S
L
P
K
S
T
S
T
G
L
G
E
Site 92
S1055
M
S
L
P
K
S
T
S
T
G
L
G
E
A
L
Site 93
S1066
G
E
A
L
G
P
A
S
R
R
T
S
S
S
G
Site 94
T1069
L
G
P
A
S
R
R
T
S
S
S
G
S
A
E
Site 95
S1070
G
P
A
S
R
R
T
S
S
S
G
S
A
E
P
Site 96
S1071
P
A
S
R
R
T
S
S
S
G
S
A
E
P
G
Site 97
S1072
A
S
R
R
T
S
S
S
G
S
A
E
P
G
A
Site 98
S1074
R
R
T
S
S
S
G
S
A
E
P
G
A
A
H
Site 99
S1085
G
A
A
H
E
M
K
S
P
P
S
A
R
S
S
Site 100
S1088
H
E
M
K
S
P
P
S
A
R
S
S
P
H
S
Site 101
S1091
K
S
P
P
S
A
R
S
S
P
H
S
P
W
S
Site 102
S1092
S
P
P
S
A
R
S
S
P
H
S
P
W
S
A
Site 103
S1095
S
A
R
S
S
P
H
S
P
W
S
A
A
S
S
Site 104
S1098
S
S
P
H
S
P
W
S
A
A
S
S
W
T
S
Site 105
S1101
H
S
P
W
S
A
A
S
S
W
T
S
R
R
S
Site 106
S1102
S
P
W
S
A
A
S
S
W
T
S
R
R
S
S
Site 107
T1104
W
S
A
A
S
S
W
T
S
R
R
S
S
R
N
Site 108
S1105
S
A
A
S
S
W
T
S
R
R
S
S
R
N
S
Site 109
S1108
S
S
W
T
S
R
R
S
S
R
N
S
L
G
R
Site 110
S1109
S
W
T
S
R
R
S
S
R
N
S
L
G
R
A
Site 111
S1112
S
R
R
S
S
R
N
S
L
G
R
A
P
S
L
Site 112
S1118
N
S
L
G
R
A
P
S
L
K
R
R
S
P
S
Site 113
S1123
A
P
S
L
K
R
R
S
P
S
G
E
R
R
S
Site 114
S1125
S
L
K
R
R
S
P
S
G
E
R
R
S
L
L
Site 115
S1130
S
P
S
G
E
R
R
S
L
L
S
G
E
G
Q
Site 116
S1133
G
E
R
R
S
L
L
S
G
E
G
Q
E
S
Q
Site 117
S1139
L
S
G
E
G
Q
E
S
Q
D
E
E
E
S
S
Site 118
S1146
S
Q
D
E
E
E
S
S
E
E
E
R
A
S
P
Site 119
S1152
S
S
E
E
E
R
A
S
P
A
G
S
D
H
R
Site 120
S1156
E
R
A
S
P
A
G
S
D
H
R
H
R
G
S
Site 121
S1163
S
D
H
R
H
R
G
S
L
E
R
E
A
K
S
Site 122
S1170
S
L
E
R
E
A
K
S
S
F
D
L
P
D
T
Site 123
S1171
L
E
R
E
A
K
S
S
F
D
L
P
D
T
L
Site 124
T1177
S
S
F
D
L
P
D
T
L
Q
V
P
G
L
H
Site 125
T1186
Q
V
P
G
L
H
R
T
A
S
G
R
G
S
A
Site 126
S1188
P
G
L
H
R
T
A
S
G
R
G
S
A
S
E
Site 127
S1192
R
T
A
S
G
R
G
S
A
S
E
H
Q
D
C
Site 128
S1194
A
S
G
R
G
S
A
S
E
H
Q
D
C
N
G
Site 129
S1203
H
Q
D
C
N
G
K
S
A
S
G
R
L
A
R
Site 130
S1205
D
C
N
G
K
S
A
S
G
R
L
A
R
A
L
Site 131
S1231
A
D
D
E
G
N
L
S
K
G
E
R
V
R
A
Site 132
Y1257
E
R
D
S
W
S
A
Y
I
F
P
P
Q
S
R
Site 133
S1304
R
P
K
I
D
P
H
S
A
E
R
I
F
L
T
Site 134
S1345
E
Q
A
Y
L
R
S
S
W
N
V
L
D
G
L
Site 135
T1450
G
E
D
T
R
N
I
T
N
K
S
D
C
A
E
Site 136
S1453
T
R
N
I
T
N
K
S
D
C
A
E
A
S
Y
Site 137
Y1460
S
D
C
A
E
A
S
Y
R
W
V
R
H
K
Y
Site 138
Y1593
S
E
A
Q
C
K
P
Y
Y
S
D
Y
S
R
F
Site 139
Y1594
E
A
Q
C
K
P
Y
Y
S
D
Y
S
R
F
R
Site 140
Y1597
C
K
P
Y
Y
S
D
Y
S
R
F
R
L
L
V
Site 141
S1598
K
P
Y
Y
S
D
Y
S
R
F
R
L
L
V
H
Site 142
Y1633
V
T
M
A
M
E
H
Y
Q
Q
P
Q
I
L
D
Site 143
S1700
E
E
I
E
V
N
A
S
L
P
I
N
P
T
I
Site 144
T1773
G
D
L
E
C
D
E
T
H
P
C
E
G
L
G
Site 145
T1784
E
G
L
G
R
H
A
T
F
R
N
F
G
M
A
Site 146
T1800
L
T
L
F
R
V
S
T
G
D
N
W
N
G
I
Site 147
Y1822
C
D
Q
E
S
T
C
Y
N
T
V
I
S
P
I
Site 148
T1824
Q
E
S
T
C
Y
N
T
V
I
S
P
I
Y
F
Site 149
T1877
E
L
E
L
E
M
K
T
L
S
P
Q
P
H
S
Site 150
S1879
E
L
E
M
K
T
L
S
P
Q
P
H
S
P
L
Site 151
S1884
T
L
S
P
Q
P
H
S
P
L
G
S
P
F
L
Site 152
S1888
Q
P
H
S
P
L
G
S
P
F
L
W
P
G
V
Site 153
S1900
P
G
V
E
G
P
D
S
P
D
S
P
K
P
G
Site 154
S1903
E
G
P
D
S
P
D
S
P
K
P
G
A
L
H
Site 155
S1919
A
A
H
A
R
S
A
S
H
F
S
L
E
H
P
Site 156
S1922
A
R
S
A
S
H
F
S
L
E
H
P
T
D
R
Site 157
S1961
A
G
P
G
G
Q
P
S
A
F
P
S
A
P
S
Site 158
S1965
G
Q
P
S
A
F
P
S
A
P
S
L
G
G
S
Site 159
S1968
S
A
F
P
S
A
P
S
L
G
G
S
D
P
Q
Site 160
S1972
S
A
P
S
L
G
G
S
D
P
Q
I
P
L
A
Site 161
T2001
P
S
C
S
L
A
L
T
D
D
S
L
P
D
D
Site 162
S2004
S
L
A
L
T
D
D
S
L
P
D
D
M
H
T
Site 163
S2015
D
M
H
T
L
L
L
S
A
L
E
S
N
M
Q
Site 164
S2019
L
L
L
S
A
L
E
S
N
M
Q
P
H
P
T
Site 165
T2026
S
N
M
Q
P
H
P
T
E
L
P
G
P
D
L
Site 166
T2035
L
P
G
P
D
L
L
T
V
R
K
S
G
V
S
Site 167
S2039
D
L
L
T
V
R
K
S
G
V
S
R
T
H
S
Site 168
S2042
T
V
R
K
S
G
V
S
R
T
H
S
L
P
N
Site 169
S2046
S
G
V
S
R
T
H
S
L
P
N
D
S
Y
M
Site 170
Y2052
H
S
L
P
N
D
S
Y
M
C
R
H
G
S
T
Site 171
S2058
S
Y
M
C
R
H
G
S
T
A
E
G
P
L
G
Site 172
S2076
W
G
L
P
K
A
Q
S
G
S
V
L
S
V
H
Site 173
S2078
L
P
K
A
Q
S
G
S
V
L
S
V
H
S
Q
Site 174
S2081
A
Q
S
G
S
V
L
S
V
H
S
Q
P
A
D
Site 175
S2084
G
S
V
L
S
V
H
S
Q
P
A
D
T
S
Y
Site 176
S2090
H
S
Q
P
A
D
T
S
Y
I
L
Q
L
P
K
Site 177
Y2091
S
Q
P
A
D
T
S
Y
I
L
Q
L
P
K
D
Site 178
S2107
P
H
L
L
Q
P
H
S
A
P
T
W
G
T
I
Site 179
S2123
K
L
P
P
P
G
R
S
P
L
A
Q
R
P
L
Site 180
S2140
Q
A
A
I
R
T
D
S
L
D
V
Q
G
L
G
Site 181
S2157
E
D
L
L
A
E
V
S
G
P
S
P
P
L
A
Site 182
S2160
L
A
E
V
S
G
P
S
P
P
L
A
R
A
Y
Site 183
Y2167
S
P
P
L
A
R
A
Y
S
F
W
G
Q
S
S
Site 184
S2168
P
P
L
A
R
A
Y
S
F
W
G
Q
S
S
T
Site 185
S2174
Y
S
F
W
G
Q
S
S
T
Q
A
Q
Q
H
S
Site 186
T2175
S
F
W
G
Q
S
S
T
Q
A
Q
Q
H
S
R
Site 187
S2181
S
T
Q
A
Q
Q
H
S
R
S
H
S
K
I
S
Site 188
S2183
Q
A
Q
Q
H
S
R
S
H
S
K
I
S
K
H
Site 189
S2185
Q
Q
H
S
R
S
H
S
K
I
S
K
H
M
T
Site 190
S2188
S
R
S
H
S
K
I
S
K
H
M
T
P
P
A
Site 191
T2192
S
K
I
S
K
H
M
T
P
P
A
P
C
P
G
Site 192
T2211
W
G
K
G
P
P
E
T
R
S
S
L
E
L
D
Site 193
S2214
G
P
P
E
T
R
S
S
L
E
L
D
T
E
L
Site 194
T2219
R
S
S
L
E
L
D
T
E
L
S
W
I
S
G
Site 195
S2239
G
G
Q
E
E
P
P
S
P
R
D
L
K
K
C
Site 196
Y2247
P
R
D
L
K
K
C
Y
S
V
E
A
Q
S
C
Site 197
S2248
R
D
L
K
K
C
Y
S
V
E
A
Q
S
C
Q
Site 198
S2253
C
Y
S
V
E
A
Q
S
C
Q
R
R
P
T
S
Site 199
T2259
Q
S
C
Q
R
R
P
T
S
W
L
D
E
Q
R
Site 200
S2260
S
C
Q
R
R
P
T
S
W
L
D
E
Q
R
R
Site 201
S2269
L
D
E
Q
R
R
H
S
I
A
V
S
C
L
D
Site 202
S2273
R
R
H
S
I
A
V
S
C
L
D
S
G
S
Q
Site 203
S2279
V
S
C
L
D
S
G
S
Q
P
H
L
G
T
D
Site 204
T2285
G
S
Q
P
H
L
G
T
D
P
S
N
L
G
G
Site 205
S2288
P
H
L
G
T
D
P
S
N
L
G
G
Q
P
L
Site 206
S2300
Q
P
L
G
G
P
G
S
R
P
K
K
K
L
S
Site 207
S2307
S
R
P
K
K
K
L
S
P
P
S
I
T
I
D
Site 208
S2310
K
K
K
L
S
P
P
S
I
T
I
D
P
P
E
Site 209
T2312
K
L
S
P
P
S
I
T
I
D
P
P
E
S
Q
Site 210
S2318
I
T
I
D
P
P
E
S
Q
G
P
R
T
P
P
Site 211
T2323
P
E
S
Q
G
P
R
T
P
P
S
P
G
I
C
Site 212
S2326
Q
G
P
R
T
P
P
S
P
G
I
C
L
R
R
Site 213
S2337
C
L
R
R
R
A
P
S
S
D
S
K
D
P
L
Site 214
S2338
L
R
R
R
A
P
S
S
D
S
K
D
P
L
A
Site 215
S2340
R
R
A
P
S
S
D
S
K
D
P
L
A
S
G
Site 216
S2346
D
S
K
D
P
L
A
S
G
P
P
D
S
M
A
Site 217
S2351
L
A
S
G
P
P
D
S
M
A
A
S
P
S
P
Site 218
S2355
P
P
D
S
M
A
A
S
P
S
P
K
K
D
V
Site 219
S2357
D
S
M
A
A
S
P
S
P
K
K
D
V
L
S
Site 220
S2364
S
P
K
K
D
V
L
S
L
S
G
L
S
S
D
Site 221
S2366
K
K
D
V
L
S
L
S
G
L
S
S
D
P
A
Site 222
S2370
L
S
L
S
G
L
S
S
D
P
A
D
L
D
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation