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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ATP8B1
Full Name:
Probable phospholipid-transporting ATPase IC
Alias:
AT8B1; ATPase class I type 8B member 1; ATPase, class I, type 8B, member 1; ATPIC; Benign recurrent intrahepatic cholestasis; BRIC; E1-E2 ATPase; EC 3.6.3.1; Familial intrahepatic cholestasis type 1; FIC1; PFIC; PFIC1; Phospholipid-transporting ATPase IC; Progressive familial intrahepatic cholestasis 1, Byler disease
Type:
EC 3.6.3.1; Hydrolase; Transporter
Mass (Da):
143695
Number AA:
1251
UniProt ID:
O43520
International Prot ID:
IPI00012851
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016324
GO:0005887
GO:0005624
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0015662
GO:0000287
PhosphoSite+
KinaseNET
Biological Process:
GO:0006754
GO:0015721
GO:0016481
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
S
T
E
R
D
S
E
T
T
F
D
E
D
Site 2
T9
S
T
E
R
D
S
E
T
T
F
D
E
D
S
Q
Site 3
T10
T
E
R
D
S
E
T
T
F
D
E
D
S
Q
P
Site 4
S15
E
T
T
F
D
E
D
S
Q
P
N
D
E
V
V
Site 5
Y24
P
N
D
E
V
V
P
Y
S
D
D
E
T
E
D
Site 6
S25
N
D
E
V
V
P
Y
S
D
D
E
T
E
D
E
Site 7
T29
V
P
Y
S
D
D
E
T
E
D
E
L
D
D
Q
Site 8
S38
D
E
L
D
D
Q
G
S
A
V
E
P
E
Q
N
Site 9
Y73
V
K
A
N
D
R
K
Y
H
E
Q
P
H
F
M
Site 10
Y92
L
C
I
K
E
S
K
Y
A
N
N
A
I
K
T
Site 11
T99
Y
A
N
N
A
I
K
T
Y
K
Y
N
A
F
T
Site 12
Y102
N
A
I
K
T
Y
K
Y
N
A
F
T
F
I
P
Site 13
S222
L
S
S
S
E
P
N
S
L
C
Y
V
E
T
A
Site 14
Y225
S
E
P
N
S
L
C
Y
V
E
T
A
E
L
D
Site 15
S242
T
N
L
K
F
K
M
S
L
E
I
T
D
Q
Y
Site 16
T246
F
K
M
S
L
E
I
T
D
Q
Y
L
Q
R
E
Site 17
Y249
S
L
E
I
T
D
Q
Y
L
Q
R
E
D
T
L
Site 18
T255
Q
Y
L
Q
R
E
D
T
L
A
T
F
D
G
F
Site 19
T258
Q
R
E
D
T
L
A
T
F
D
G
F
I
E
C
Site 20
T276
N
N
R
L
D
K
F
T
G
T
L
F
W
R
N
Site 21
T278
R
L
D
K
F
T
G
T
L
F
W
R
N
T
S
Site 22
T284
G
T
L
F
W
R
N
T
S
F
P
L
D
A
D
Site 23
S285
T
L
F
W
R
N
T
S
F
P
L
D
A
D
K
Site 24
Y335
F
K
R
T
K
I
D
Y
L
M
N
Y
M
V
Y
Site 25
Y372
Q
V
G
N
S
S
W
Y
L
Y
D
G
E
D
D
Site 26
Y374
G
N
S
S
W
Y
L
Y
D
G
E
D
D
T
P
Site 27
T380
L
Y
D
G
E
D
D
T
P
S
Y
R
G
F
L
Site 28
S382
D
G
E
D
D
T
P
S
Y
R
G
F
L
I
F
Site 29
Y383
G
E
D
D
T
P
S
Y
R
G
F
L
I
F
W
Site 30
T432
M
Y
Y
A
E
K
D
T
P
A
K
A
R
T
T
Site 31
T439
T
P
A
K
A
R
T
T
T
L
N
E
Q
L
G
Site 32
T440
P
A
K
A
R
T
T
T
L
N
E
Q
L
G
Q
Site 33
Y450
E
Q
L
G
Q
I
H
Y
I
F
S
D
K
T
G
Site 34
T456
H
Y
I
F
S
D
K
T
G
T
L
T
Q
N
I
Site 35
T460
S
D
K
T
G
T
L
T
Q
N
I
M
T
F
K
Site 36
Y476
C
C
I
N
G
Q
I
Y
G
D
H
R
D
A
S
Site 37
Y500
V
D
F
S
W
N
T
Y
A
D
G
K
L
A
F
Site 38
Y508
A
D
G
K
L
A
F
Y
D
H
Y
L
I
E
Q
Site 39
Y511
K
L
A
F
Y
D
H
Y
L
I
E
Q
I
Q
S
Site 40
S518
Y
L
I
E
Q
I
Q
S
G
K
E
P
E
V
R
Site 41
Y548
R
T
D
G
Q
L
N
Y
Q
A
A
S
P
D
E
Site 42
S552
Q
L
N
Y
Q
A
A
S
P
D
E
G
A
L
V
Site 43
S580
T
Q
N
T
I
T
I
S
E
L
G
T
E
R
T
Site 44
T584
I
T
I
S
E
L
G
T
E
R
T
Y
N
V
L
Site 45
Y588
E
L
G
T
E
R
T
Y
N
V
L
A
I
L
D
Site 46
S598
L
A
I
L
D
F
N
S
D
R
K
R
M
S
I
Site 47
S604
N
S
D
R
K
R
M
S
I
I
V
R
T
P
E
Site 48
T609
R
M
S
I
I
V
R
T
P
E
G
N
I
K
L
Site 49
Y617
P
E
G
N
I
K
L
Y
C
K
G
A
D
T
V
Site 50
T623
L
Y
C
K
G
A
D
T
V
I
Y
E
R
L
H
Site 51
Y626
K
G
A
D
T
V
I
Y
E
R
L
H
R
M
N
Site 52
T653
F
A
N
E
T
L
R
T
L
C
L
C
Y
K
E
Site 53
T667
E
I
E
E
K
E
F
T
E
W
N
K
K
F
M
Site 54
S677
N
K
K
F
M
A
A
S
V
A
S
T
N
R
D
Site 55
T681
M
A
A
S
V
A
S
T
N
R
D
E
A
L
D
Site 56
Y691
D
E
A
L
D
K
V
Y
E
E
I
E
K
D
L
Site 57
T754
E
L
L
T
E
D
T
T
I
C
Y
G
E
D
I
Site 58
Y757
T
E
D
T
T
I
C
Y
G
E
D
I
N
S
L
Site 59
S789
F
A
P
P
V
Q
E
S
F
F
P
P
G
G
N
Site 60
T815
E
I
L
L
E
K
K
T
K
R
N
K
I
L
K
Site 61
T828
L
K
L
K
F
P
R
T
E
E
E
R
R
M
R
Site 62
T836
E
E
E
R
R
M
R
T
Q
S
K
R
R
L
E
Site 63
S838
E
R
R
M
R
T
Q
S
K
R
R
L
E
A
K
Site 64
S921
E
G
M
Q
A
V
M
S
S
D
Y
S
F
A
Q
Site 65
S922
G
M
Q
A
V
M
S
S
D
Y
S
F
A
Q
F
Site 66
Y924
Q
A
V
M
S
S
D
Y
S
F
A
Q
F
R
Y
Site 67
S925
A
V
M
S
S
D
Y
S
F
A
Q
F
R
Y
L
Site 68
Y980
G
Y
S
A
Q
T
A
Y
E
D
W
F
I
T
L
Site 69
Y992
I
T
L
Y
N
V
L
Y
T
S
L
P
V
L
L
Site 70
S1008
G
L
L
D
Q
D
V
S
D
K
L
S
L
R
F
Site 71
S1012
Q
D
V
S
D
K
L
S
L
R
F
P
G
L
Y
Site 72
Y1030
Q
R
D
L
L
F
N
Y
K
R
F
F
V
S
L
Site 73
T1058
P
L
G
A
Y
L
Q
T
V
G
Q
D
G
E
A
Site 74
S1067
G
Q
D
G
E
A
P
S
D
Y
Q
S
F
A
V
Site 75
Y1069
D
G
E
A
P
S
D
Y
Q
S
F
A
V
T
I
Site 76
S1071
E
A
P
S
D
Y
Q
S
F
A
V
T
I
A
S
Site 77
S1137
F
Q
F
T
G
T
A
S
N
A
L
R
Q
P
Y
Site 78
T1169
A
I
R
F
L
S
M
T
I
W
P
S
E
S
D
Site 79
S1173
L
S
M
T
I
W
P
S
E
S
D
K
I
Q
K
Site 80
S1203
Q
V
F
R
R
G
V
S
T
R
R
S
A
Y
A
Site 81
T1204
V
F
R
R
G
V
S
T
R
R
S
A
Y
A
F
Site 82
S1207
R
G
V
S
T
R
R
S
A
Y
A
F
S
H
Q
Site 83
Y1209
V
S
T
R
R
S
A
Y
A
F
S
H
Q
R
G
Site 84
S1212
R
R
S
A
Y
A
F
S
H
Q
R
G
Y
A
D
Site 85
Y1217
A
F
S
H
Q
R
G
Y
A
D
L
I
S
S
G
Site 86
S1222
R
G
Y
A
D
L
I
S
S
G
R
S
I
R
K
Site 87
S1223
G
Y
A
D
L
I
S
S
G
R
S
I
R
K
K
Site 88
S1226
D
L
I
S
S
G
R
S
I
R
K
K
R
S
P
Site 89
S1232
R
S
I
R
K
K
R
S
P
L
D
A
I
V
A
Site 90
Y1245
V
A
D
G
T
A
E
Y
R
R
T
G
D
S
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation