KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
TGM5
Full Name:
Protein-glutamine gamma-glutamyltransferase 5
Alias:
EC 2.3.2.13; TG; TGase 5; TGase X; TGM6; TGMX; TGX; Transglutaminase X; Transglutaminase-5
Type:
Enzyme - Transferase, glutamyltransferase
Mass (Da):
80778
Number AA:
720
UniProt ID:
O43548
International Prot ID:
IPI00012876
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0008415
GO:0005509
GO:0003810
PhosphoSite+
KinaseNET
Biological Process:
GO:0008544
GO:0018149
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T10
Q
G
L
E
V
A
L
T
D
L
Q
S
S
R
N
Site 2
S14
V
A
L
T
D
L
Q
S
S
R
N
N
V
R
H
Site 3
T23
R
N
N
V
R
H
H
T
E
E
I
T
V
D
H
Site 4
T27
R
H
H
T
E
E
I
T
V
D
H
L
L
V
R
Site 5
T42
R
G
Q
A
F
N
L
T
L
Y
F
R
N
R
S
Site 6
Y44
Q
A
F
N
L
T
L
Y
F
R
N
R
S
F
Q
Site 7
S49
T
L
Y
F
R
N
R
S
F
Q
P
G
L
D
N
Site 8
S78
L
G
T
R
A
V
F
S
L
A
R
H
H
S
P
Site 9
S84
F
S
L
A
R
H
H
S
P
S
P
W
I
A
W
Site 10
S86
L
A
R
H
H
S
P
S
P
W
I
A
W
L
E
Site 11
S127
H
I
D
S
F
Q
G
S
V
T
A
Y
Q
L
G
Site 12
Y150
W
C
P
E
D
A
V
Y
L
D
S
E
P
Q
R
Site 13
S153
E
D
A
V
Y
L
D
S
E
P
Q
R
Q
E
Y
Site 14
Y160
S
E
P
Q
R
Q
E
Y
V
M
N
D
Y
G
F
Site 15
Y165
Q
E
Y
V
M
N
D
Y
G
F
I
Y
Q
G
S
Site 16
S201
C
L
K
L
L
D
K
S
L
H
F
Q
T
D
P
Site 17
T210
H
F
Q
T
D
P
A
T
D
C
A
L
R
G
S
Site 18
S217
T
D
C
A
L
R
G
S
P
V
Y
V
S
R
V
Site 19
Y220
A
L
R
G
S
P
V
Y
V
S
R
V
V
C
A
Site 20
Y246
N
G
N
W
S
E
N
Y
T
D
G
A
N
P
A
Site 21
T247
G
N
W
S
E
N
Y
T
D
G
A
N
P
A
E
Site 22
T300
G
I
P
T
R
V
I
T
N
F
D
S
G
H
D
Site 23
S304
R
V
I
T
N
F
D
S
G
H
D
T
D
G
N
Site 24
T308
N
F
D
S
G
H
D
T
D
G
N
L
I
I
D
Site 25
Y317
G
N
L
I
I
D
E
Y
Y
D
N
T
G
R
I
Site 26
Y318
N
L
I
I
D
E
Y
Y
D
N
T
G
R
I
L
Site 27
T321
I
D
E
Y
Y
D
N
T
G
R
I
L
G
N
K
Site 28
Y353
R
K
D
L
P
P
A
Y
G
G
W
Q
V
L
D
Site 29
T362
G
W
Q
V
L
D
A
T
P
Q
E
M
S
N
G
Site 30
Y371
Q
E
M
S
N
G
V
Y
C
C
G
P
A
S
V
Site 31
Y390
E
G
E
V
D
L
N
Y
D
T
P
F
V
F
S
Site 32
S421
Q
K
L
H
Q
D
T
S
S
V
G
N
F
I
S
Site 33
S422
K
L
H
Q
D
T
S
S
V
G
N
F
I
S
T
Site 34
S428
S
S
V
G
N
F
I
S
T
K
S
I
Q
S
D
Site 35
S431
G
N
F
I
S
T
K
S
I
Q
S
D
E
R
D
Site 36
S434
I
S
T
K
S
I
Q
S
D
E
R
D
D
I
T
Site 37
T441
S
D
E
R
D
D
I
T
E
N
Y
K
Y
E
E
Site 38
Y444
R
D
D
I
T
E
N
Y
K
Y
E
E
G
S
L
Site 39
Y446
D
I
T
E
N
Y
K
Y
E
E
G
S
L
Q
E
Site 40
S468
L
Q
K
L
K
A
R
S
F
H
G
S
Q
R
G
Site 41
S472
K
A
R
S
F
H
G
S
Q
R
G
A
E
L
Q
Site 42
S481
R
G
A
E
L
Q
P
S
R
P
T
S
L
S
Q
Site 43
T484
E
L
Q
P
S
R
P
T
S
L
S
Q
D
S
P
Site 44
S485
L
Q
P
S
R
P
T
S
L
S
Q
D
S
P
R
Site 45
S487
P
S
R
P
T
S
L
S
Q
D
S
P
R
S
L
Site 46
S490
P
T
S
L
S
Q
D
S
P
R
S
L
H
T
P
Site 47
S493
L
S
Q
D
S
P
R
S
L
H
T
P
S
L
R
Site 48
T496
D
S
P
R
S
L
H
T
P
S
L
R
P
S
D
Site 49
S498
P
R
S
L
H
T
P
S
L
R
P
S
D
V
V
Site 50
S502
H
T
P
S
L
R
P
S
D
V
V
Q
V
S
L
Site 51
S544
K
D
L
K
V
N
L
S
A
Q
S
L
L
H
D
Site 52
S547
K
V
N
L
S
A
Q
S
L
L
H
D
G
S
P
Site 53
S553
Q
S
L
L
H
D
G
S
P
L
S
P
F
W
Q
Site 54
S556
L
H
D
G
S
P
L
S
P
F
W
Q
D
T
A
Site 55
T566
W
Q
D
T
A
F
I
T
L
S
P
K
E
A
K
Site 56
S568
D
T
A
F
I
T
L
S
P
K
E
A
K
T
Y
Site 57
T574
L
S
P
K
E
A
K
T
Y
P
C
K
I
S
Y
Site 58
Y575
S
P
K
E
A
K
T
Y
P
C
K
I
S
Y
S
Site 59
Y581
T
Y
P
C
K
I
S
Y
S
Q
Y
S
Q
Y
L
Site 60
S582
Y
P
C
K
I
S
Y
S
Q
Y
S
Q
Y
L
S
Site 61
Y584
C
K
I
S
Y
S
Q
Y
S
Q
Y
L
S
T
D
Site 62
S585
K
I
S
Y
S
Q
Y
S
Q
Y
L
S
T
D
K
Site 63
Y587
S
Y
S
Q
Y
S
Q
Y
L
S
T
D
K
L
I
Site 64
S589
S
Q
Y
S
Q
Y
L
S
T
D
K
L
I
R
I
Site 65
S597
T
D
K
L
I
R
I
S
A
L
G
E
E
K
S
Site 66
S604
S
A
L
G
E
E
K
S
S
P
E
K
I
L
V
Site 67
S605
A
L
G
E
E
K
S
S
P
E
K
I
L
V
N
Site 68
S681
L
K
P
Q
H
Q
A
S
I
I
L
E
T
V
P
Site 69
S691
L
E
T
V
P
F
K
S
G
Q
R
Q
I
Q
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation