PhosphoNET

           
Protein Info 
   
Short Name:  Spry1
Full Name:  Protein sprouty homolog 1
Alias:  hSPRY1; sprouty 1, antagonist of FGF signaling; Sprouty homolog 1; Spry-1; SPY1
Type:  Adaptor/scaffold; Inhibitor protein
Mass (Da):  35122
Number AA:  319
UniProt ID:  O43609
International Prot ID:  IPI00306505
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005829  GO:0019898  GO:0030027 Uniprot OncoNet
Molecular Function:      PhosphoSite+ KinaseNET
Biological Process:      Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S9DPQNQHGSGSSLVVI
Site 2S12NQHGSGSSLVVIQQP
Site 3S20LVVIQQPSLDSRQRL
Site 4Y29DSRQRLDYEREIQPT
Site 5T36YEREIQPTAILSLDQ
Site 6S50QIKAIRGSNEYTEGP
Site 7Y53AIRGSNEYTEGPSVV
Site 8T54IRGSNEYTEGPSVVK
Site 9S58NEYTEGPSVVKRPAP
Site 10T67VKRPAPRTAPRQEKH
Site 11Y89PINVNNNYEHRHTSH
Site 12T94NNYEHRHTSHLGHAV
Site 13S112NARGPILSRSTSTGS
Site 14S114RGPILSRSTSTGSAA
Site 15T115GPILSRSTSTGSAAS
Site 16S116PILSRSTSTGSAASS
Site 17T117ILSRSTSTGSAASSG
Site 18S119SRSTSTGSAASSGSN
Site 19S123STGSAASSGSNSSAS
Site 20S125GSAASSGSNSSASSE
Site 21S127AASSGSNSSASSEQG
Site 22S128ASSGSNSSASSEQGL
Site 23S130SGSNSSASSEQGLLG
Site 24S131GSNSSASSEQGLLGR
Site 25S139EQGLLGRSPPTRPVP
Site 26T142LLGRSPPTRPVPGHR
Site 27S150RPVPGHRSERAIRTQ
Site 28T156RSERAIRTQPKQLIV
Site 29S169IVDDLKGSLKEDLTQ
Site 30T175GSLKEDLTQHKFICE
Site 31T193KCKCGECTAPRTLPS
Site 32S200TAPRTLPSCLACNRQ
Site 33Y230CLVKGIFYHCSNDDE
Site 34S240SNDDEGDSYSDNPCS
Site 35Y241NDDEGDSYSDNPCSC
Site 36S242DDEGDSYSDNPCSCS
Site 37Y287LKLCRRCYDWIHRPG
Site 38Y304CKNSNTVYCKLESCP
Site 39S309TVYCKLESCPSRGQG
Site 40S312CKLESCPSRGQGKPS
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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