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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NCK2
Full Name:
Cytoplasmic protein NCK2
Alias:
GRB4; NCK adaptor protein 2; Nck-2; NCKbeta; SH2,SH3 adaptor protein NCK-beta; SH2/SH3 adaptor protein NCK-beta
Type:
Adaptor/scaffold protein
Mass (Da):
42915
Number AA:
380
UniProt ID:
O43639
International Prot ID:
IPI00306531
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005783
Uniprot
OncoNet
Molecular Function:
GO:0008093
GO:0030159
PhosphoSite+
KinaseNET
Biological Process:
GO:0042110
GO:0007173
GO:0008285
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y13
I
V
I
A
K
W
D
Y
T
A
Q
Q
D
Q
E
Site 2
T14
V
I
A
K
W
D
Y
T
A
Q
Q
D
Q
E
L
Site 3
T48
V
R
N
A
A
N
R
T
G
Y
V
P
S
N
Y
Site 4
Y50
N
A
A
N
R
T
G
Y
V
P
S
N
Y
V
E
Site 5
S53
N
R
T
G
Y
V
P
S
N
Y
V
E
R
K
N
Site 6
Y55
T
G
Y
V
P
S
N
Y
V
E
R
K
N
S
L
Site 7
S61
N
Y
V
E
R
K
N
S
L
K
K
G
S
L
V
Site 8
S66
K
N
S
L
K
K
G
S
L
V
K
N
L
K
D
Site 9
T74
L
V
K
N
L
K
D
T
L
G
L
G
K
T
R
Site 10
T80
D
T
L
G
L
G
K
T
R
R
K
T
S
A
R
Site 11
T84
L
G
K
T
R
R
K
T
S
A
R
D
A
S
P
Site 12
S85
G
K
T
R
R
K
T
S
A
R
D
A
S
P
T
Site 13
S90
K
T
S
A
R
D
A
S
P
T
P
S
T
D
A
Site 14
T92
S
A
R
D
A
S
P
T
P
S
T
D
A
E
Y
Site 15
S94
R
D
A
S
P
T
P
S
T
D
A
E
Y
P
A
Site 16
T95
D
A
S
P
T
P
S
T
D
A
E
Y
P
A
N
Site 17
Y99
T
P
S
T
D
A
E
Y
P
A
N
G
S
G
A
Site 18
S104
A
E
Y
P
A
N
G
S
G
A
D
R
I
Y
D
Site 19
Y110
G
S
G
A
D
R
I
Y
D
L
N
I
P
A
F
Site 20
Y122
P
A
F
V
K
F
A
Y
V
A
E
R
E
D
E
Site 21
S131
A
E
R
E
D
E
L
S
L
V
K
G
S
R
V
Site 22
T139
L
V
K
G
S
R
V
T
V
M
E
K
C
S
D
Site 23
Y164
I
G
W
F
P
S
N
Y
V
L
E
E
V
D
E
Site 24
S176
V
D
E
A
A
A
E
S
P
S
F
L
S
L
R
Site 25
S178
E
A
A
A
E
S
P
S
F
L
S
L
R
K
G
Site 26
S181
A
E
S
P
S
F
L
S
L
R
K
G
A
S
L
Site 27
S187
L
S
L
R
K
G
A
S
L
S
N
G
Q
G
S
Site 28
S189
L
R
K
G
A
S
L
S
N
G
Q
G
S
R
V
Site 29
S207
V
Q
T
L
Y
P
F
S
S
V
T
E
E
E
L
Site 30
S208
Q
T
L
Y
P
F
S
S
V
T
E
E
E
L
N
Site 31
T221
L
N
F
E
K
G
E
T
M
E
V
I
E
K
P
Site 32
S270
P
A
H
A
P
Q
I
S
Y
T
G
P
S
S
S
Site 33
Y271
A
H
A
P
Q
I
S
Y
T
G
P
S
S
S
G
Site 34
T272
H
A
P
Q
I
S
Y
T
G
P
S
S
S
G
R
Site 35
S276
I
S
Y
T
G
P
S
S
S
G
R
F
A
G
R
Site 36
S277
S
Y
T
G
P
S
S
S
G
R
F
A
G
R
E
Site 37
Y286
R
F
A
G
R
E
W
Y
Y
G
N
V
T
R
H
Site 38
Y287
F
A
G
R
E
W
Y
Y
G
N
V
T
R
H
Q
Site 39
S313
G
D
F
L
I
R
D
S
E
S
S
P
S
D
F
Site 40
S315
F
L
I
R
D
S
E
S
S
P
S
D
F
S
V
Site 41
S316
L
I
R
D
S
E
S
S
P
S
D
F
S
V
S
Site 42
S318
R
D
S
E
S
S
P
S
D
F
S
V
S
L
K
Site 43
S321
E
S
S
P
S
D
F
S
V
S
L
K
A
S
G
Site 44
S323
S
P
S
D
F
S
V
S
L
K
A
S
G
K
N
Site 45
S327
F
S
V
S
L
K
A
S
G
K
N
K
H
F
K
Site 46
Y342
V
Q
L
V
D
N
V
Y
C
I
G
Q
R
R
F
Site 47
T351
I
G
Q
R
R
F
H
T
M
D
E
L
V
E
H
Site 48
S367
K
K
A
P
I
F
T
S
E
H
G
E
K
L
Y
Site 49
Y374
S
E
H
G
E
K
L
Y
L
V
R
A
L
Q
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation