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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PRC1
Full Name:
Protein regulator of cytokinesis 1
Alias:
MGC1671; MGC3669
Type:
Cytoskeletal protein; Cell cycle regulation; Microtubule binding protein
Mass (Da):
71607
Number AA:
620
UniProt ID:
O43663
International Prot ID:
IPI00022629
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
GO:0005876
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0005515
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0000910
GO:0000022
GO:0007017
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S4
_
_
_
_
M
R
R
S
E
V
L
A
E
E
S
Site 2
S11
S
E
V
L
A
E
E
S
I
V
C
L
Q
K
A
Site 3
T40
E
D
Q
R
L
Q
R
T
E
V
V
K
K
H
I
Site 4
S60
M
M
I
A
E
E
E
S
L
K
E
R
L
I
K
Site 5
S68
L
K
E
R
L
I
K
S
I
S
V
C
Q
K
E
Site 6
S70
E
R
L
I
K
S
I
S
V
C
Q
K
E
L
N
Site 7
S81
K
E
L
N
T
L
C
S
E
L
H
V
E
P
F
Site 8
T94
P
F
Q
E
E
G
E
T
T
I
L
Q
L
E
K
Site 9
T95
F
Q
E
E
G
E
T
T
I
L
Q
L
E
K
D
Site 10
S144
M
P
H
Y
D
I
D
S
A
S
V
P
S
L
E
Site 11
S146
H
Y
D
I
D
S
A
S
V
P
S
L
E
E
L
Site 12
T162
Q
F
R
Q
H
V
T
T
L
R
E
T
K
A
S
Site 13
T166
H
V
T
T
L
R
E
T
K
A
S
R
R
E
E
Site 14
S169
T
L
R
E
T
K
A
S
R
R
E
E
F
V
S
Site 15
S176
S
R
R
E
E
F
V
S
I
K
R
Q
I
I
L
Site 16
T191
C
M
E
A
L
D
H
T
P
D
T
S
F
E
R
Site 17
T194
A
L
D
H
T
P
D
T
S
F
E
R
D
V
V
Site 18
S195
L
D
H
T
P
D
T
S
F
E
R
D
V
V
C
Site 19
S230
R
Q
L
E
M
Q
K
S
Q
N
E
A
V
C
E
Site 20
T241
A
V
C
E
G
L
R
T
Q
I
R
E
L
W
D
Site 21
T262
E
E
R
E
A
V
A
T
I
M
S
G
S
K
A
Site 22
S265
E
A
V
A
T
I
M
S
G
S
K
A
K
V
R
Site 23
Y304
I
R
V
E
L
V
Q
Y
W
D
Q
C
F
Y
S
Site 24
T327
P
F
C
A
E
D
Y
T
E
S
L
L
Q
L
H
Site 25
Y344
E
I
V
R
L
K
N
Y
Y
E
V
H
K
E
L
Site 26
Y345
I
V
R
L
K
N
Y
Y
E
V
H
K
E
L
F
Site 27
S373
L
E
F
E
R
K
A
S
D
P
N
R
F
T
N
Site 28
T379
A
S
D
P
N
R
F
T
N
R
G
G
N
L
L
Site 29
Y464
Q
T
E
T
E
M
L
Y
G
S
A
P
R
T
P
Site 30
S466
E
T
E
M
L
Y
G
S
A
P
R
T
P
S
K
Site 31
T470
L
Y
G
S
A
P
R
T
P
S
K
R
R
G
L
Site 32
S472
G
S
A
P
R
T
P
S
K
R
R
G
L
A
P
Site 33
T481
R
R
G
L
A
P
N
T
P
G
K
A
R
K
L
Site 34
T490
G
K
A
R
K
L
N
T
T
T
M
S
N
A
T
Site 35
T491
K
A
R
K
L
N
T
T
T
M
S
N
A
T
A
Site 36
S501
S
N
A
T
A
N
S
S
I
R
P
I
F
G
G
Site 37
Y511
P
I
F
G
G
T
V
Y
H
S
P
V
S
R
L
Site 38
S513
F
G
G
T
V
Y
H
S
P
V
S
R
L
P
P
Site 39
S516
T
V
Y
H
S
P
V
S
R
L
P
P
S
G
S
Site 40
S521
P
V
S
R
L
P
P
S
G
S
K
P
V
A
A
Site 41
S523
S
R
L
P
P
S
G
S
K
P
V
A
A
S
T
Site 42
S529
G
S
K
P
V
A
A
S
T
C
S
G
K
K
T
Site 43
T530
S
K
P
V
A
A
S
T
C
S
G
K
K
T
P
Site 44
S532
P
V
A
A
S
T
C
S
G
K
K
T
P
R
T
Site 45
T536
S
T
C
S
G
K
K
T
P
R
T
G
R
H
G
Site 46
T539
S
G
K
K
T
P
R
T
G
R
H
G
A
N
K
Site 47
S554
E
N
L
E
L
N
G
S
I
L
S
G
G
Y
P
Site 48
S557
E
L
N
G
S
I
L
S
G
G
Y
P
G
S
A
Site 49
Y560
G
S
I
L
S
G
G
Y
P
G
S
A
P
L
Q
Site 50
S563
L
S
G
G
Y
P
G
S
A
P
L
Q
R
N
F
Site 51
S571
A
P
L
Q
R
N
F
S
I
N
S
V
A
S
T
Site 52
S574
Q
R
N
F
S
I
N
S
V
A
S
T
Y
S
E
Site 53
S577
F
S
I
N
S
V
A
S
T
Y
S
E
F
A
K
Site 54
T578
S
I
N
S
V
A
S
T
Y
S
E
F
A
K
D
Site 55
Y579
I
N
S
V
A
S
T
Y
S
E
F
A
K
D
P
Site 56
S580
N
S
V
A
S
T
Y
S
E
F
A
K
D
P
S
Site 57
S587
S
E
F
A
K
D
P
S
L
S
D
S
S
T
V
Site 58
S589
F
A
K
D
P
S
L
S
D
S
S
T
V
G
L
Site 59
S591
K
D
P
S
L
S
D
S
S
T
V
G
L
Q
R
Site 60
S592
D
P
S
L
S
D
S
S
T
V
G
L
Q
R
E
Site 61
T593
P
S
L
S
D
S
S
T
V
G
L
Q
R
E
L
Site 62
S601
V
G
L
Q
R
E
L
S
K
A
S
K
S
D
A
Site 63
S604
Q
R
E
L
S
K
A
S
K
S
D
A
T
S
G
Site 64
S606
E
L
S
K
A
S
K
S
D
A
T
S
G
I
L
Site 65
S610
A
S
K
S
D
A
T
S
G
I
L
N
S
T
N
Site 66
S615
A
T
S
G
I
L
N
S
T
N
I
Q
S
_
_
Site 67
T616
T
S
G
I
L
N
S
T
N
I
Q
S
_
_
_
Site 68
S620
L
N
S
T
N
I
Q
S
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation