KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
CYTH3
Full Name:
Cytohesin-3
Alias:
ARF nucleotide-binding site opener 3; General receptor of phosphoinositides 1; Grp1; PH, SEC7 and coiled-coil domain-containing protein 3; Protein ARNO3
Type:
Guanine-nucleotide exchange protein for ARF1
Mass (Da):
46349
Number AA:
400
UniProt ID:
O43739
International Prot ID:
IPI00013892
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005624
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005086
GO:0008095
GO:0005545
PhosphoSite+
KinaseNET
Biological Process:
GO:0032012
GO:0016192
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S17
G
G
V
P
E
D
L
S
L
E
E
R
E
E
L
Site 2
Y43
D
D
I
E
R
L
K
Y
E
I
A
E
V
M
T
Site 3
T56
M
T
E
I
D
N
L
T
S
V
E
E
S
K
T
Site 4
S57
T
E
I
D
N
L
T
S
V
E
E
S
K
T
T
Site 5
S61
N
L
T
S
V
E
E
S
K
T
T
Q
R
N
K
Site 6
T63
T
S
V
E
E
S
K
T
T
Q
R
N
K
Q
I
Site 7
T64
S
V
E
E
S
K
T
T
Q
R
N
K
Q
I
A
Site 8
S97
E
N
D
L
L
Q
S
S
P
E
D
V
A
Q
F
Site 9
Y106
E
D
V
A
Q
F
L
Y
K
G
E
G
L
N
K
Site 10
T114
K
G
E
G
L
N
K
T
V
I
G
D
Y
L
G
Site 11
Y119
N
K
T
V
I
G
D
Y
L
G
E
R
D
E
F
Site 12
S155
A
L
R
Q
F
L
W
S
F
R
L
P
G
E
A
Site 13
T214
H
N
V
R
D
K
P
T
A
E
R
F
I
A
M
Site 14
Y240
E
E
L
L
R
N
L
Y
E
S
I
K
N
E
P
Site 15
S242
L
L
R
N
L
Y
E
S
I
K
N
E
P
F
K
Site 16
T259
E
D
D
G
N
D
L
T
H
T
F
F
N
P
D
Site 17
T261
D
G
N
D
L
T
H
T
F
F
N
P
D
R
E
Site 18
T281
L
G
G
G
R
V
K
T
W
K
R
R
W
F
I
Site 19
Y295
I
L
T
D
N
C
L
Y
Y
F
E
Y
T
T
D
Site 20
Y296
L
T
D
N
C
L
Y
Y
F
E
Y
T
T
D
K
Site 21
Y299
N
C
L
Y
Y
F
E
Y
T
T
D
K
E
P
R
Site 22
S315
I
I
P
L
E
N
L
S
I
R
E
V
E
D
P
Site 23
Y331
K
P
N
C
F
E
L
Y
N
P
S
H
K
G
Q
Site 24
Y359
V
E
G
N
H
V
V
Y
R
I
S
A
P
S
P
Site 25
S362
N
H
V
V
Y
R
I
S
A
P
S
P
E
E
K
Site 26
S365
V
Y
R
I
S
A
P
S
P
E
E
K
E
E
W
Site 27
S375
E
K
E
E
W
M
K
S
I
K
A
S
I
S
R
Site 28
S379
W
M
K
S
I
K
A
S
I
S
R
D
P
F
Y
Site 29
S381
K
S
I
K
A
S
I
S
R
D
P
F
Y
D
M
Site 30
Y386
S
I
S
R
D
P
F
Y
D
M
L
A
T
R
K
Site 31
T391
P
F
Y
D
M
L
A
T
R
K
R
R
I
A
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation