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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PRKAB2
Full Name:
5'-AMP-activated protein kinase subunit beta-2
Alias:
5'-AMP-activated protein kinase; 5'-AMP-activated protein kinase, beta-2 subunit; AAKB2; AAKC; AMPK beta 2; AMPK beta-2 chain; AMPK-beta2; Beta-2 subunit; Protein kinase, AMP-activated, beta 2 non-catalytic subunit
Type:
Protein-serine kinase, CAMK group, CAMKL family, AMPK subfamily
Mass (Da):
30302
Number AA:
272
UniProt ID:
O43741
International Prot ID:
IPI00013905
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005654
GO:0044422
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006633
GO:0046320
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T4
_
_
_
_
M
G
N
T
T
S
D
R
V
S
G
Site 2
T5
_
_
_
M
G
N
T
T
S
D
R
V
S
G
E
Site 3
S6
_
_
M
G
N
T
T
S
D
R
V
S
G
E
R
Site 4
S10
N
T
T
S
D
R
V
S
G
E
R
H
G
A
K
Site 5
S21
H
G
A
K
A
A
R
S
E
G
A
G
G
H
A
Site 6
S39
E
H
K
I
M
V
G
S
T
D
D
P
S
V
F
Site 7
T40
H
K
I
M
V
G
S
T
D
D
P
S
V
F
S
Site 8
S44
V
G
S
T
D
D
P
S
V
F
S
L
P
D
S
Site 9
S47
T
D
D
P
S
V
F
S
L
P
D
S
K
L
P
Site 10
S51
S
V
F
S
L
P
D
S
K
L
P
G
D
K
E
Site 11
S61
P
G
D
K
E
F
V
S
W
Q
Q
D
L
E
D
Site 12
S69
W
Q
Q
D
L
E
D
S
V
K
P
T
Q
Q
A
Site 13
T73
L
E
D
S
V
K
P
T
Q
Q
A
R
P
T
V
Site 14
T79
P
T
Q
Q
A
R
P
T
V
I
R
W
S
E
G
Site 15
S84
R
P
T
V
I
R
W
S
E
G
G
K
E
V
F
Site 16
S93
G
G
K
E
V
F
I
S
G
S
F
N
N
W
S
Site 17
S95
K
E
V
F
I
S
G
S
F
N
N
W
S
T
K
Site 18
S100
S
G
S
F
N
N
W
S
T
K
I
P
L
I
K
Site 19
T101
G
S
F
N
N
W
S
T
K
I
P
L
I
K
S
Site 20
S108
T
K
I
P
L
I
K
S
H
N
D
F
V
A
I
Site 21
S138
G
Q
W
V
H
D
P
S
E
P
V
V
T
S
Q
Site 22
T143
D
P
S
E
P
V
V
T
S
Q
L
G
T
I
N
Site 23
S144
P
S
E
P
V
V
T
S
Q
L
G
T
I
N
N
Site 24
T148
V
V
T
S
Q
L
G
T
I
N
N
L
I
H
V
Site 25
S158
N
L
I
H
V
K
K
S
D
F
E
V
F
D
A
Site 26
S170
F
D
A
L
K
L
D
S
M
E
S
S
E
T
S
Site 27
S173
L
K
L
D
S
M
E
S
S
E
T
S
C
R
D
Site 28
S174
K
L
D
S
M
E
S
S
E
T
S
C
R
D
L
Site 29
T176
D
S
M
E
S
S
E
T
S
C
R
D
L
S
S
Site 30
S177
S
M
E
S
S
E
T
S
C
R
D
L
S
S
S
Site 31
S182
E
T
S
C
R
D
L
S
S
S
P
P
G
P
Y
Site 32
S183
T
S
C
R
D
L
S
S
S
P
P
G
P
Y
G
Site 33
S184
S
C
R
D
L
S
S
S
P
P
G
P
Y
G
Q
Site 34
Y189
S
S
S
P
P
G
P
Y
G
Q
E
M
Y
A
F
Site 35
Y194
G
P
Y
G
Q
E
M
Y
A
F
R
S
E
E
R
Site 36
S198
Q
E
M
Y
A
F
R
S
E
E
R
F
K
S
P
Site 37
S204
R
S
E
E
R
F
K
S
P
P
I
L
P
P
H
Site 38
Y242
H
V
M
L
N
H
L
Y
A
L
S
I
K
D
S
Site 39
S254
K
D
S
V
M
V
L
S
A
T
H
R
Y
K
K
Site 40
T256
S
V
M
V
L
S
A
T
H
R
Y
K
K
K
Y
Site 41
Y263
T
H
R
Y
K
K
K
Y
V
T
T
L
L
Y
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation