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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NARS
Full Name:
Asparaginyl-tRNA synthetase, cytoplasmic
Alias:
AsnRS; ASNS; Asparagine-tRNA ligase; Asparagine--tRNA ligase; Asparaginyl-tRNA synthetase; EC 6.1.1.22; SYNC
Type:
Enzyme, tRNA ligase
Mass (Da):
62943
Number AA:
548
UniProt ID:
O43776
International Prot ID:
IPI00306960
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005625
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004816
GO:0004815
PhosphoSite+
KinaseNET
Biological Process:
GO:0006421
GO:0006422
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y7
_
M
V
L
A
E
L
Y
V
S
D
R
E
G
S
Site 2
S9
V
L
A
E
L
Y
V
S
D
R
E
G
S
D
A
Site 3
S14
Y
V
S
D
R
E
G
S
D
A
T
G
D
G
T
Site 4
T21
S
D
A
T
G
D
G
T
K
E
K
P
F
K
T
Site 5
T43
V
G
K
E
P
F
P
T
I
Y
V
D
S
Q
K
Site 6
Y45
K
E
P
F
P
T
I
Y
V
D
S
Q
K
E
N
Site 7
S59
N
E
R
W
N
V
I
S
K
S
Q
L
K
N
I
Site 8
S61
R
W
N
V
I
S
K
S
Q
L
K
N
I
K
K
Site 9
S77
W
H
R
E
Q
M
K
S
E
S
R
E
K
K
E
Site 10
S88
E
K
K
E
A
E
D
S
L
R
R
E
K
N
L
Site 11
S108
I
T
I
K
N
D
P
S
L
P
E
P
K
C
V
Site 12
T188
V
Y
G
M
L
N
L
T
P
K
G
K
Q
A
P
Site 13
S224
D
N
L
I
N
E
E
S
D
V
D
V
Q
L
N
Site 14
S243
M
I
R
G
E
N
M
S
K
I
L
K
A
R
S
Site 15
S250
S
K
I
L
K
A
R
S
M
V
T
R
C
F
R
Site 16
Y265
D
H
F
F
D
R
G
Y
Y
E
V
T
P
P
T
Site 17
Y266
H
F
F
D
R
G
Y
Y
E
V
T
P
P
T
L
Site 18
T269
D
R
G
Y
Y
E
V
T
P
P
T
L
V
Q
T
Site 19
T297
F
G
E
E
A
F
L
T
Q
S
S
Q
L
Y
L
Site 20
S300
E
A
F
L
T
Q
S
S
Q
L
Y
L
E
T
C
Site 21
S320
D
V
F
C
I
A
Q
S
Y
R
A
E
Q
S
R
Site 22
T328
Y
R
A
E
Q
S
R
T
R
R
H
L
A
E
Y
Site 23
Y335
T
R
R
H
L
A
E
Y
T
H
V
E
A
E
C
Site 24
T346
E
A
E
C
P
F
L
T
F
D
D
L
L
N
R
Site 25
Y393
R
P
F
K
R
M
N
Y
S
D
A
I
V
W
L
Site 26
S394
P
F
K
R
M
N
Y
S
D
A
I
V
W
L
K
Site 27
T411
D
V
K
K
E
D
G
T
F
Y
E
F
G
E
D
Site 28
Y413
K
K
E
D
G
T
F
Y
E
F
G
E
D
I
P
Site 29
T428
E
A
P
E
R
L
M
T
D
T
I
N
E
P
I
Site 30
T430
P
E
R
L
M
T
D
T
I
N
E
P
I
L
L
Site 31
Y448
P
V
E
I
K
S
F
Y
M
Q
R
C
P
E
D
Site 32
S456
M
Q
R
C
P
E
D
S
R
L
T
E
S
V
D
Site 33
T459
C
P
E
D
S
R
L
T
E
S
V
D
V
L
M
Site 34
S461
E
D
S
R
L
T
E
S
V
D
V
L
M
P
N
Site 35
S482
G
S
M
R
I
F
D
S
E
E
I
L
A
G
Y
Site 36
Y489
S
E
E
I
L
A
G
Y
K
R
E
G
I
D
P
Site 37
T497
K
R
E
G
I
D
P
T
P
Y
Y
W
Y
T
D
Site 38
Y499
E
G
I
D
P
T
P
Y
Y
W
Y
T
D
Q
R
Site 39
Y500
G
I
D
P
T
P
Y
Y
W
Y
T
D
Q
R
K
Site 40
Y508
W
Y
T
D
Q
R
K
Y
G
T
C
P
H
G
G
Site 41
T525
L
G
L
E
R
F
L
T
W
I
L
N
R
Y
H
Site 42
Y539
H
I
R
D
V
C
L
Y
P
R
F
V
Q
R
C
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation