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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DYRK3
Full Name:
Dual specificity tyrosine-phosphorylation-regulated kinase 3
Alias:
EC 2.7.12.1; REDK; Regulatory erythroid kinase
Type:
Protein kinase, dual-specificity, CMGC group, DYRK family, Dyrk2 subfamily
Mass (Da):
65714
Number AA:
588
UniProt ID:
O43781
International Prot ID:
IPI00465460
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0000287
GO:0004674
PhosphoSite+
KinaseNET
Biological Process:
GO:0030218
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y32
R
R
L
G
D
G
V
Y
D
T
F
M
M
I
D
Site 2
S54
S
N
V
L
C
N
P
S
E
P
P
P
P
R
R
Site 3
T65
P
P
R
R
L
N
M
T
T
E
Q
F
T
G
D
Site 4
T66
P
R
R
L
N
M
T
T
E
Q
F
T
G
D
H
Site 5
T74
E
Q
F
T
G
D
H
T
Q
H
F
L
D
G
G
Site 6
S97
Q
E
F
G
N
R
K
S
N
T
I
Q
S
D
G
Site 7
T99
F
G
N
R
K
S
N
T
I
Q
S
D
G
I
S
Site 8
S102
R
K
S
N
T
I
Q
S
D
G
I
S
D
S
E
Site 9
S106
T
I
Q
S
D
G
I
S
D
S
E
K
C
S
P
Site 10
S108
Q
S
D
G
I
S
D
S
E
K
C
S
P
T
V
Site 11
S112
I
S
D
S
E
K
C
S
P
T
V
S
Q
G
K
Site 12
T114
D
S
E
K
C
S
P
T
V
S
Q
G
K
S
S
Site 13
S116
E
K
C
S
P
T
V
S
Q
G
K
S
S
D
C
Site 14
S120
P
T
V
S
Q
G
K
S
S
D
C
L
N
T
V
Site 15
T126
K
S
S
D
C
L
N
T
V
K
S
N
S
S
S
Site 16
S129
D
C
L
N
T
V
K
S
N
S
S
S
K
A
P
Site 17
S131
L
N
T
V
K
S
N
S
S
S
K
A
P
K
V
Site 18
S133
T
V
K
S
N
S
S
S
K
A
P
K
V
V
P
Site 19
T142
A
P
K
V
V
P
L
T
P
E
Q
A
L
K
Q
Site 20
T155
K
Q
Y
K
H
H
L
T
A
Y
E
K
L
E
I
Site 21
Y157
Y
K
H
H
L
T
A
Y
E
K
L
E
I
I
N
Site 22
Y190
G
G
P
N
N
G
G
Y
D
D
A
D
G
A
Y
Site 23
Y197
Y
D
D
A
D
G
A
Y
I
H
V
P
R
D
H
Site 24
Y207
V
P
R
D
H
L
A
Y
R
Y
E
V
L
K
I
Site 25
Y209
R
D
H
L
A
Y
R
Y
E
V
L
K
I
I
G
Site 26
Y227
F
G
Q
V
A
R
V
Y
D
H
K
L
R
Q
Y
Site 27
Y234
Y
D
H
K
L
R
Q
Y
V
A
L
K
M
V
R
Site 28
T266
H
L
K
K
Q
D
K
T
G
S
M
N
V
I
H
Site 29
S268
K
K
Q
D
K
T
G
S
M
N
V
I
H
M
L
Site 30
Y296
E
L
L
S
I
D
L
Y
E
L
I
K
K
N
K
Site 31
S318
L
V
R
K
F
A
Q
S
I
L
Q
S
L
D
A
Site 32
S322
F
A
Q
S
I
L
Q
S
L
D
A
L
H
K
N
Site 33
S350
L
K
H
H
G
R
S
S
T
K
V
I
D
F
G
Site 34
T351
K
H
H
G
R
S
S
T
K
V
I
D
F
G
S
Site 35
S358
T
K
V
I
D
F
G
S
S
C
F
E
Y
Q
K
Site 36
Y363
F
G
S
S
C
F
E
Y
Q
K
L
Y
T
Y
I
Site 37
Y367
C
F
E
Y
Q
K
L
Y
T
Y
I
Q
S
R
F
Site 38
T368
F
E
Y
Q
K
L
Y
T
Y
I
Q
S
R
F
Y
Site 39
Y369
E
Y
Q
K
L
Y
T
Y
I
Q
S
R
F
Y
R
Site 40
S372
K
L
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
Site 41
Y375
T
Y
I
Q
S
R
F
Y
R
A
P
E
I
I
L
Site 42
S384
A
P
E
I
I
L
G
S
R
Y
S
T
P
I
D
Site 43
S436
P
P
K
L
L
E
Q
S
K
R
A
K
Y
F
I
Site 44
Y441
E
Q
S
K
R
A
K
Y
F
I
N
S
K
G
I
Site 45
Y451
N
S
K
G
I
P
R
Y
C
S
V
T
T
Q
A
Site 46
S453
K
G
I
P
R
Y
C
S
V
T
T
Q
A
D
G
Site 47
T455
I
P
R
Y
C
S
V
T
T
Q
A
D
G
R
V
Site 48
T456
P
R
Y
C
S
V
T
T
Q
A
D
G
R
V
V
Site 49
S469
V
V
L
V
G
G
R
S
R
R
G
K
K
R
G
Site 50
S480
K
K
R
G
P
P
G
S
K
D
W
G
T
A
L
Site 51
T485
P
G
S
K
D
W
G
T
A
L
K
G
C
D
D
Site 52
S508
R
C
L
H
W
D
P
S
A
R
L
T
P
A
Q
Site 53
T512
W
D
P
S
A
R
L
T
P
A
Q
A
L
R
H
Site 54
S523
A
L
R
H
P
W
I
S
K
S
V
P
R
P
L
Site 55
S525
R
H
P
W
I
S
K
S
V
P
R
P
L
T
T
Site 56
T531
K
S
V
P
R
P
L
T
T
I
D
K
V
S
G
Site 57
T532
S
V
P
R
P
L
T
T
I
D
K
V
S
G
K
Site 58
S537
L
T
T
I
D
K
V
S
G
K
R
V
V
N
P
Site 59
S546
K
R
V
V
N
P
A
S
A
F
Q
G
L
G
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation