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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SPOP
Full Name:
Speckle-type POZ protein
Alias:
HIB 1; Roadkill 1; TEF2
Type:
Uncharacterized protein
Mass (Da):
42132
Number AA:
374
UniProt ID:
O43791
International Prot ID:
IPI00013978
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006397
GO:0019941
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
S
R
V
P
S
P
P
P
P
A
E
M
Site 2
S14
P
P
P
P
A
E
M
S
S
G
P
V
A
E
S
Site 3
S15
P
P
P
A
E
M
S
S
G
P
V
A
E
S
W
Site 4
S21
S
S
G
P
V
A
E
S
W
C
Y
T
Q
I
K
Site 5
Y24
P
V
A
E
S
W
C
Y
T
Q
I
K
V
V
K
Site 6
S54
E
M
G
E
V
I
K
S
S
T
F
S
S
G
A
Site 7
S55
M
G
E
V
I
K
S
S
T
F
S
S
G
A
N
Site 8
T56
G
E
V
I
K
S
S
T
F
S
S
G
A
N
D
Site 9
S58
V
I
K
S
S
T
F
S
S
G
A
N
D
K
L
Site 10
S59
I
K
S
S
T
F
S
S
G
A
N
D
K
L
K
Site 11
S80
P
K
G
L
D
E
E
S
K
D
Y
L
S
L
Y
Site 12
Y83
L
D
E
E
S
K
D
Y
L
S
L
Y
L
L
L
Site 13
S96
L
L
V
S
C
P
K
S
E
V
R
A
K
F
K
Site 14
S119
E
E
T
K
A
M
E
S
Q
R
A
Y
R
F
V
Site 15
Y123
A
M
E
S
Q
R
A
Y
R
F
V
Q
G
K
D
Site 16
S167
E
V
S
V
V
Q
D
S
V
N
I
S
G
Q
N
Site 17
T175
V
N
I
S
G
Q
N
T
M
N
M
V
K
V
P
Site 18
S226
A
A
R
S
P
V
F
S
A
M
F
E
H
E
M
Site 19
S236
F
E
H
E
M
E
E
S
K
K
N
R
V
E
I
Site 20
Y259
K
E
M
M
C
F
I
Y
T
G
K
A
P
N
L
Site 21
S313
L
I
L
A
D
L
H
S
A
D
Q
L
K
T
Q
Site 22
S330
D
F
I
N
Y
H
A
S
D
V
L
E
T
S
G
Site 23
S340
L
E
T
S
G
W
K
S
M
V
V
S
H
P
H
Site 24
S344
G
W
K
S
M
V
V
S
H
P
H
L
V
A
E
Site 25
Y353
P
H
L
V
A
E
A
Y
R
S
L
A
S
A
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation