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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
AKAP8
Full Name:
A-kinase anchor protein 8
Alias:
A kinase (PRKA) anchor protein 8; AKA8; AKAP 95; AKAP95; A-kinase anchor protein 95 kDa; A-kinase anchor protein, 95kDa; DKFZp586B1222
Type:
Adapter/scaffold protein
Mass (Da):
76108
Number AA:
692
UniProt ID:
O43823
International Prot ID:
IPI00014474
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016363
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y32
G
V
A
S
W
Q
G
Y
E
N
Y
N
Y
Y
G
Site 2
Y35
S
W
Q
G
Y
E
N
Y
N
Y
Y
G
A
Q
N
Site 3
Y37
Q
G
Y
E
N
Y
N
Y
Y
G
A
Q
N
T
S
Site 4
Y38
G
Y
E
N
Y
N
Y
Y
G
A
Q
N
T
S
V
Site 5
S44
Y
Y
G
A
Q
N
T
S
V
T
T
G
A
T
Y
Site 6
S52
V
T
T
G
A
T
Y
S
Y
G
P
A
S
W
E
Site 7
S57
T
Y
S
Y
G
P
A
S
W
E
A
A
K
A
N
Site 8
S79
A
P
A
M
H
M
A
S
Y
G
P
E
P
C
T
Site 9
T86
S
Y
G
P
E
P
C
T
D
N
S
D
S
L
I
Site 10
S89
P
E
P
C
T
D
N
S
D
S
L
I
A
K
I
Site 11
S91
P
C
T
D
N
S
D
S
L
I
A
K
I
N
Q
Site 12
S104
N
Q
R
L
D
M
M
S
K
E
G
G
R
G
G
Site 13
S112
K
E
G
G
R
G
G
S
G
G
G
G
E
G
I
Site 14
S124
E
G
I
Q
D
R
E
S
S
F
R
F
Q
P
F
Site 15
S125
G
I
Q
D
R
E
S
S
F
R
F
Q
P
F
E
Site 16
S133
F
R
F
Q
P
F
E
S
Y
D
S
R
P
C
L
Site 17
Y134
R
F
Q
P
F
E
S
Y
D
S
R
P
C
L
P
Site 18
S136
Q
P
F
E
S
Y
D
S
R
P
C
L
P
E
H
Site 19
Y146
C
L
P
E
H
N
P
Y
R
P
S
Y
S
Y
D
Site 20
S149
E
H
N
P
Y
R
P
S
Y
S
Y
D
Y
E
F
Site 21
Y150
H
N
P
Y
R
P
S
Y
S
Y
D
Y
E
F
D
Site 22
Y152
P
Y
R
P
S
Y
S
Y
D
Y
E
F
D
L
G
Site 23
Y154
R
P
S
Y
S
Y
D
Y
E
F
D
L
G
S
D
Site 24
S160
D
Y
E
F
D
L
G
S
D
R
N
G
S
F
G
Site 25
S165
L
G
S
D
R
N
G
S
F
G
G
Q
Y
S
E
Site 26
Y170
N
G
S
F
G
G
Q
Y
S
E
C
R
D
P
A
Site 27
S171
G
S
F
G
G
Q
Y
S
E
C
R
D
P
A
R
Site 28
S182
D
P
A
R
E
R
G
S
L
D
G
F
M
R
G
Site 29
S199
Q
G
R
F
Q
D
R
S
N
P
G
T
F
M
R
Site 30
T203
Q
D
R
S
N
P
G
T
F
M
R
S
D
P
F
Site 31
S207
N
P
G
T
F
M
R
S
D
P
F
V
P
P
A
Site 32
S216
P
F
V
P
P
A
A
S
S
E
P
L
S
T
P
Site 33
S217
F
V
P
P
A
A
S
S
E
P
L
S
T
P
W
Site 34
S221
A
A
S
S
E
P
L
S
T
P
W
N
E
L
N
Site 35
T222
A
S
S
E
P
L
S
T
P
W
N
E
L
N
Y
Site 36
Y229
T
P
W
N
E
L
N
Y
V
G
G
R
G
L
G
Site 37
S239
G
R
G
L
G
G
P
S
P
S
R
P
P
P
S
Site 38
S241
G
L
G
G
P
S
P
S
R
P
P
P
S
L
F
Site 39
S246
S
P
S
R
P
P
P
S
L
F
S
Q
S
M
A
Site 40
S249
R
P
P
P
S
L
F
S
Q
S
M
A
P
D
Y
Site 41
S251
P
P
S
L
F
S
Q
S
M
A
P
D
Y
G
V
Site 42
Y256
S
Q
S
M
A
P
D
Y
G
V
M
G
M
Q
G
Site 43
Y267
G
M
Q
G
A
G
G
Y
D
S
T
M
P
Y
G
Site 44
T270
G
A
G
G
Y
D
S
T
M
P
Y
G
C
G
R
Site 45
Y273
G
Y
D
S
T
M
P
Y
G
C
G
R
S
Q
P
Site 46
S278
M
P
Y
G
C
G
R
S
Q
P
R
M
R
D
R
Site 47
T301
D
R
F
G
P
D
G
T
G
R
K
R
K
Q
F
Site 48
Y311
K
R
K
Q
F
Q
L
Y
E
E
P
D
T
K
L
Site 49
T316
Q
L
Y
E
E
P
D
T
K
L
A
R
V
D
S
Site 50
S323
T
K
L
A
R
V
D
S
E
G
D
F
S
E
N
Site 51
S328
V
D
S
E
G
D
F
S
E
N
D
D
A
A
G
Site 52
S339
D
A
A
G
D
F
R
S
G
D
E
E
F
K
G
Site 53
S353
G
E
D
E
L
C
D
S
G
R
Q
R
G
E
K
Site 54
T380
K
Q
R
R
R
D
R
T
R
D
R
A
A
D
R
Site 55
S399
C
S
V
C
K
F
R
S
F
D
D
E
E
I
Q
Site 56
T417
Q
S
K
F
H
K
E
T
L
R
F
I
S
T
K
Site 57
S422
K
E
T
L
R
F
I
S
T
K
L
P
D
K
T
Site 58
T423
E
T
L
R
F
I
S
T
K
L
P
D
K
T
V
Site 59
T429
S
T
K
L
P
D
K
T
V
E
F
L
Q
E
Y
Site 60
Y436
T
V
E
F
L
Q
E
Y
I
V
N
R
N
K
K
Site 61
S519
A
E
Q
F
K
K
T
S
L
H
V
A
K
S
V
Site 62
S525
T
S
L
H
V
A
K
S
V
L
N
N
R
H
I
Site 63
Y539
I
V
K
M
L
E
K
Y
L
K
G
E
D
P
F
Site 64
T547
L
K
G
E
D
P
F
T
S
E
T
V
D
P
E
Site 65
T550
E
D
P
F
T
S
E
T
V
D
P
E
M
E
G
Site 66
T569
G
G
E
D
K
K
E
T
P
E
E
V
A
A
D
Site 67
S599
E
G
A
P
A
P
E
S
S
G
E
P
A
E
D
Site 68
S600
G
A
P
A
P
E
S
S
G
E
P
A
E
D
E
Site 69
T612
E
D
E
G
P
T
D
T
A
E
A
G
S
D
P
Site 70
S644
K
G
V
P
K
A
R
S
E
A
A
E
A
G
N
Site 71
T681
A
D
A
E
V
E
Q
T
D
A
E
S
K
D
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation