KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
IDH3B
Full Name:
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
Alias:
H-IDHB; Isocitrate dehydrogenase [NAD] beta, mitochondrial; Isocitrate dehydrogenase 3 (NAD+) beta; Isocitric dehydrogenase; NAD(+)-specific ICDH; NAD(+)-specific isocitrate dehydrogenase b
Type:
Carbohydrate Metabolism - citrate (TCA) cycle; EC 1.1.1.41; Oxidoreductase
Mass (Da):
42184
Number AA:
385
UniProt ID:
O43837
International Prot ID:
IPI00304417
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005759
Uniprot
OncoNet
Molecular Function:
GO:0051287
GO:0009055
GO:0004449
PhosphoSite+
KinaseNET
Biological Process:
GO:0006102
GO:0055114
GO:0050896
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S27
P
G
A
W
R
G
L
S
T
S
A
A
A
H
A
Site 2
S29
A
W
R
G
L
S
T
S
A
A
A
H
A
A
S
Site 3
S38
A
A
H
A
A
S
R
S
Q
A
E
D
V
R
V
Site 4
S48
E
D
V
R
V
E
G
S
F
P
V
T
M
L
P
Site 5
S86
E
F
Q
E
H
H
L
S
E
V
Q
N
M
A
S
Site 6
S93
S
E
V
Q
N
M
A
S
E
E
K
L
E
Q
V
Site 7
S102
E
K
L
E
Q
V
L
S
S
M
K
E
N
K
V
Site 8
T117
A
I
I
G
K
I
H
T
P
M
E
Y
K
G
E
Site 9
S127
E
Y
K
G
E
L
A
S
Y
D
M
R
L
R
R
Site 10
Y128
Y
K
G
E
L
A
S
Y
D
M
R
L
R
R
K
Site 11
S147
A
N
V
V
H
V
K
S
L
P
G
Y
M
T
R
Site 12
Y151
H
V
K
S
L
P
G
Y
M
T
R
H
N
N
L
Site 13
T153
K
S
L
P
G
Y
M
T
R
H
N
N
L
D
L
Site 14
T167
L
V
I
I
R
E
Q
T
E
G
E
Y
S
S
L
Site 15
S172
E
Q
T
E
G
E
Y
S
S
L
E
H
E
S
A
Site 16
S173
Q
T
E
G
E
Y
S
S
L
E
H
E
S
A
R
Site 17
S178
Y
S
S
L
E
H
E
S
A
R
G
V
I
E
C
Site 18
S194
K
I
V
T
R
A
K
S
Q
R
I
A
K
F
A
Site 19
Y204
I
A
K
F
A
F
D
Y
A
T
K
K
G
R
G
Site 20
T206
K
F
A
F
D
Y
A
T
K
K
G
R
G
K
V
Site 21
Y240
C
E
E
V
A
E
L
Y
P
K
I
K
F
E
T
Site 22
S328
N
P
T
A
M
L
L
S
A
S
N
M
L
R
H
Site 23
S330
T
A
M
L
L
S
A
S
N
M
L
R
H
L
N
Site 24
Y340
L
R
H
L
N
L
E
Y
H
S
S
M
I
A
D
Site 25
S343
L
N
L
E
Y
H
S
S
M
I
A
D
A
V
K
Site 26
Y366
R
T
R
D
M
G
G
Y
S
T
T
T
D
F
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation