KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
CREB3
Full Name:
Cyclic AMP-responsive element-binding protein 3
Alias:
Luman;Transcription factor LZIP-alpha
Type:
Mass (Da):
43917
Number AA:
395
UniProt ID:
O43889
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S42
L
D
W
A
L
P
L
S
E
V
P
S
D
W
E
Site 2
S46
L
P
L
S
E
V
P
S
D
W
E
V
D
D
L
Site 3
Y81
L
V
H
H
D
H
T
Y
S
L
P
R
E
T
V
Site 4
S82
V
H
H
D
H
T
Y
S
L
P
R
E
T
V
S
Site 5
T87
T
Y
S
L
P
R
E
T
V
S
M
D
L
G
E
Site 6
S89
S
L
P
R
E
T
V
S
M
D
L
G
E
C
E
Site 7
S98
D
L
G
E
C
E
I
S
L
T
G
R
T
G
F
Site 8
T100
G
E
C
E
I
S
L
T
G
R
T
G
F
M
G
Site 9
S120
F
P
F
A
E
S
E
S
C
R
K
E
G
T
Q
Site 10
T129
R
K
E
G
T
Q
M
T
P
Q
H
M
E
E
L
Site 11
S152
V
L
T
D
E
E
K
S
L
L
E
K
E
G
L
Site 12
T164
E
G
L
I
L
P
E
T
L
P
L
T
K
T
E
Site 13
T168
L
P
E
T
L
P
L
T
K
T
E
E
Q
I
L
Site 14
T170
E
T
L
P
L
T
K
T
E
E
Q
I
L
K
R
Site 15
S187
R
K
I
R
N
K
R
S
A
Q
E
S
R
R
K
Site 16
S191
N
K
R
S
A
Q
E
S
R
R
K
K
K
V
Y
Site 17
Y198
S
R
R
K
K
K
V
Y
V
G
G
L
E
S
R
Site 18
S229
L
L
E
E
Q
N
L
S
L
L
D
Q
L
R
K
Site 19
S245
Q
A
M
V
I
E
I
S
N
K
T
S
S
S
S
Site 20
T248
V
I
E
I
S
N
K
T
S
S
S
S
T
C
I
Site 21
S249
I
E
I
S
N
K
T
S
S
S
S
T
C
I
L
Site 22
S273
L
V
P
A
M
Y
S
S
D
T
R
G
S
L
P
Site 23
T275
P
A
M
Y
S
S
D
T
R
G
S
L
P
A
E
Site 24
S278
Y
S
S
D
T
R
G
S
L
P
A
E
H
G
V
Site 25
S287
P
A
E
H
G
V
L
S
R
Q
L
R
A
L
P
Site 26
S295
R
Q
L
R
A
L
P
S
E
D
P
Y
Q
L
E
Site 27
Y299
A
L
P
S
E
D
P
Y
Q
L
E
L
P
A
L
Site 28
S308
L
E
L
P
A
L
Q
S
E
V
P
K
D
S
T
Site 29
S314
Q
S
E
V
P
K
D
S
T
H
Q
W
L
D
G
Site 30
T315
S
E
V
P
K
D
S
T
H
Q
W
L
D
G
S
Site 31
Y338
N
T
S
C
L
L
H
Y
M
P
Q
A
P
S
A
Site 32
S344
H
Y
M
P
Q
A
P
S
A
E
P
P
L
E
W
Site 33
S358
W
P
F
P
D
L
F
S
E
P
L
C
R
G
P
Site 34
T374
L
P
L
Q
A
N
L
T
R
K
G
G
W
L
P
Site 35
T382
R
K
G
G
W
L
P
T
G
S
P
S
V
I
L
Site 36
S384
G
G
W
L
P
T
G
S
P
S
V
I
L
Q
D
Site 37
S386
W
L
P
T
G
S
P
S
V
I
L
Q
D
R
Y
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation