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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TLL1
Full Name:
Tolloid-like protein 1
Alias:
TLL
Type:
Secreted protein
Mass (Da):
114709
Number AA:
1013
UniProt ID:
O43897
International Prot ID:
IPI00018381
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005576
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0004222
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0030154
GO:0006508
GO:0001501
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y33
W
V
C
A
G
L
D
Y
D
Y
T
F
D
G
N
Site 2
Y35
C
A
G
L
D
Y
D
Y
T
F
D
G
N
E
E
Site 3
T36
A
G
L
D
Y
D
Y
T
F
D
G
N
E
E
D
Site 4
T45
D
G
N
E
E
D
K
T
E
T
I
D
Y
K
D
Site 5
Y50
D
K
T
E
T
I
D
Y
K
D
P
C
K
A
A
Site 6
T78
N
I
F
Q
I
D
R
T
I
D
L
T
Q
N
P
Site 7
T82
I
D
R
T
I
D
L
T
Q
N
P
F
G
N
L
Site 8
S102
G
L
G
D
H
A
M
S
K
K
R
G
A
L
Y
Site 9
Y109
S
K
K
R
G
A
L
Y
Q
L
I
D
R
I
R
Site 10
T127
F
G
L
E
Q
N
N
T
V
K
G
K
V
P
L
Site 11
S137
G
K
V
P
L
Q
F
S
G
Q
N
E
K
N
R
Site 12
T150
N
R
V
P
R
A
A
T
S
R
T
E
R
I
W
Site 13
T153
P
R
A
A
T
S
R
T
E
R
I
W
P
G
G
Site 14
S173
I
G
G
N
F
T
G
S
Q
R
A
M
F
K
Q
Site 15
S197
C
V
T
F
I
E
R
S
D
E
E
S
Y
I
V
Site 16
S201
I
E
R
S
D
E
E
S
Y
I
V
F
T
Y
R
Site 17
Y215
R
P
C
G
C
C
S
Y
V
G
R
R
G
N
G
Site 18
T262
P
D
R
D
N
H
V
T
I
I
R
E
N
I
Q
Site 19
S286
M
E
P
G
E
V
N
S
L
G
E
R
Y
D
F
Site 20
Y291
V
N
S
L
G
E
R
Y
D
F
D
S
I
M
H
Site 21
Y299
D
F
D
S
I
M
H
Y
A
R
N
T
F
S
R
Site 22
T312
S
R
G
M
F
L
D
T
I
L
P
S
R
D
D
Site 23
S316
F
L
D
T
I
L
P
S
R
D
D
N
G
I
R
Site 24
S333
I
G
Q
R
T
R
L
S
K
G
D
I
A
Q
A
Site 25
Y344
I
A
Q
A
R
K
L
Y
R
C
P
A
C
G
E
Site 26
T352
R
C
P
A
C
G
E
T
L
Q
E
S
N
G
N
Site 27
S356
C
G
E
T
L
Q
E
S
N
G
N
L
S
S
P
Site 28
S361
Q
E
S
N
G
N
L
S
S
P
G
F
P
N
G
Site 29
S362
E
S
N
G
N
L
S
S
P
G
F
P
N
G
Y
Site 30
Y369
S
P
G
F
P
N
G
Y
P
S
Y
T
H
C
I
Site 31
Y397
N
F
T
T
M
D
L
Y
K
S
S
L
C
W
Y
Site 32
Y404
Y
K
S
S
L
C
W
Y
D
Y
I
E
V
R
D
Site 33
Y406
S
S
L
C
W
Y
D
Y
I
E
V
R
D
G
Y
Site 34
Y413
Y
I
E
V
R
D
G
Y
W
R
K
S
P
L
L
Site 35
S417
R
D
G
Y
W
R
K
S
P
L
L
G
R
F
C
Site 36
T433
D
K
L
P
E
V
L
T
S
T
D
S
R
M
W
Site 37
S434
K
L
P
E
V
L
T
S
T
D
S
R
M
W
I
Site 38
T435
L
P
E
V
L
T
S
T
D
S
R
M
W
I
E
Site 39
S437
E
V
L
T
S
T
D
S
R
M
W
I
E
F
R
Site 40
S475
K
N
E
G
Q
I
Q
S
P
N
Y
P
D
D
Y
Site 41
Y478
G
Q
I
Q
S
P
N
Y
P
D
D
Y
R
P
M
Site 42
Y482
S
P
N
Y
P
D
D
Y
R
P
M
K
E
C
V
Site 43
T493
K
E
C
V
W
K
I
T
V
S
E
S
Y
H
V
Site 44
T503
E
S
Y
H
V
G
L
T
F
Q
S
F
E
I
E
Site 45
S506
H
V
G
L
T
F
Q
S
F
E
I
E
R
H
D
Site 46
Y517
E
R
H
D
N
C
A
Y
D
Y
L
E
V
R
D
Site 47
Y519
H
D
N
C
A
Y
D
Y
L
E
V
R
D
G
T
Site 48
T526
Y
L
E
V
R
D
G
T
S
E
N
S
P
L
I
Site 49
S527
L
E
V
R
D
G
T
S
E
N
S
P
L
I
G
Site 50
S530
R
D
G
T
S
E
N
S
P
L
I
G
R
F
C
Site 51
Y539
L
I
G
R
F
C
G
Y
D
K
P
E
D
I
R
Site 52
S547
D
K
P
E
D
I
R
S
T
S
N
T
L
W
M
Site 53
T548
K
P
E
D
I
R
S
T
S
N
T
L
W
M
K
Site 54
S549
P
E
D
I
R
S
T
S
N
T
L
W
M
K
F
Site 55
T551
D
I
R
S
T
S
N
T
L
W
M
K
F
V
S
Site 56
Y605
Q
C
A
C
E
P
G
Y
E
L
G
P
D
R
R
Site 57
S613
E
L
G
P
D
R
R
S
C
E
A
A
C
G
G
Site 58
T630
T
K
L
N
G
T
I
T
T
P
G
W
P
K
E
Site 59
T631
K
L
N
G
T
I
T
T
P
G
W
P
K
E
Y
Site 60
Y638
T
P
G
W
P
K
E
Y
P
P
N
K
N
C
V
Site 61
S657
A
P
T
Q
Y
R
I
S
V
K
F
E
F
F
E
Site 62
Y673
E
G
N
E
V
C
K
Y
D
Y
V
E
I
W
S
Site 63
Y675
N
E
V
C
K
Y
D
Y
V
E
I
W
S
G
L
Site 64
S680
Y
D
Y
V
E
I
W
S
G
L
S
S
E
S
K
Site 65
S683
V
E
I
W
S
G
L
S
S
E
S
K
L
H
G
Site 66
S684
E
I
W
S
G
L
S
S
E
S
K
L
H
G
K
Site 67
S714
N
M
R
I
E
F
K
S
D
N
T
V
S
K
K
Site 68
T717
I
E
F
K
S
D
N
T
V
S
K
K
G
F
K
Site 69
S719
F
K
S
D
N
T
V
S
K
K
G
F
K
A
H
Site 70
S729
G
F
K
A
H
F
F
S
D
K
D
E
C
S
K
Site 71
S780
E
C
E
Q
K
I
H
S
P
S
G
L
I
T
S
Site 72
S782
E
Q
K
I
H
S
P
S
G
L
I
T
S
P
N
Site 73
T786
H
S
P
S
G
L
I
T
S
P
N
W
P
D
K
Site 74
S787
S
P
S
G
L
I
T
S
P
N
W
P
D
K
Y
Site 75
Y794
S
P
N
W
P
D
K
Y
P
S
R
K
E
C
T
Site 76
T807
C
T
W
E
I
S
A
T
P
G
H
R
I
K
L
Site 77
S817
H
R
I
K
L
A
F
S
E
F
E
I
E
Q
H
Site 78
Y829
E
Q
H
Q
E
C
A
Y
D
H
L
E
V
F
D
Site 79
S842
F
D
G
E
T
E
K
S
P
I
L
G
R
L
C
Site 80
T860
I
P
D
P
L
V
A
T
G
N
K
M
F
V
R
Site 81
S870
K
M
F
V
R
F
V
S
D
A
S
V
Q
R
K
Site 82
S873
V
R
F
V
S
D
A
S
V
Q
R
K
G
F
Q
Site 83
S884
K
G
F
Q
A
T
H
S
T
E
C
G
G
R
L
Site 84
S895
G
G
R
L
K
A
E
S
K
P
R
D
L
Y
S
Site 85
Y901
E
S
K
P
R
D
L
Y
S
H
A
Q
F
G
D
Site 86
S902
S
K
P
R
D
L
Y
S
H
A
Q
F
G
D
N
Site 87
Y911
A
Q
F
G
D
N
N
Y
P
G
Q
V
D
C
E
Site 88
S923
D
C
E
W
L
L
V
S
E
R
G
S
R
L
E
Site 89
S927
L
L
V
S
E
R
G
S
R
L
E
L
S
F
Q
Site 90
S932
R
G
S
R
L
E
L
S
F
Q
T
F
E
V
E
Site 91
T935
R
L
E
L
S
F
Q
T
F
E
V
E
E
E
A
Site 92
Y946
E
E
E
A
D
C
G
Y
D
Y
V
E
L
F
D
Site 93
Y948
E
A
D
C
G
Y
D
Y
V
E
L
F
D
G
L
Site 94
S968
G
L
G
R
F
C
G
S
G
P
P
E
E
I
Y
Site 95
Y975
S
G
P
P
E
E
I
Y
S
I
G
D
S
V
L
Site 96
T987
S
V
L
I
H
F
H
T
D
D
T
I
N
K
K
Site 97
Y1000
K
K
G
F
H
I
R
Y
K
S
I
R
Y
P
D
Site 98
S1002
G
F
H
I
R
Y
K
S
I
R
Y
P
D
T
T
Site 99
Y1005
I
R
Y
K
S
I
R
Y
P
D
T
T
H
T
K
Site 100
T1008
K
S
I
R
Y
P
D
T
T
H
T
K
K
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation