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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PRICKLE3
Full Name:
Prickle-like protein 3
Alias:
LIM-only protein 6; PRIC3; prickle 3; Prickle3; triple LIM domain protein 6
Type:
Mass (Da):
68609
Number AA:
615
UniProt ID:
O43900
International Prot ID:
IPI00015129
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
F
A
R
G
S
R
R
R
R
S
G
R
Site 2
S11
R
G
S
R
R
R
R
S
G
R
A
P
P
E
A
Site 3
S80
I
S
D
F
Q
R
H
S
I
S
D
D
D
S
G
Site 4
S82
D
F
Q
R
H
S
I
S
D
D
D
S
G
C
A
Site 5
S86
H
S
I
S
D
D
D
S
G
C
A
S
E
E
Y
Site 6
S90
D
D
D
S
G
C
A
S
E
E
Y
A
W
V
P
Site 7
Y93
S
G
C
A
S
E
E
Y
A
W
V
P
P
G
L
Site 8
Y106
G
L
K
P
E
Q
V
Y
Q
F
F
S
C
L
P
Site 9
Y119
L
P
E
D
K
V
P
Y
V
N
S
P
G
E
K
Site 10
S122
D
K
V
P
Y
V
N
S
P
G
E
K
Y
R
I
Site 11
Y145
P
H
D
S
E
A
Q
Y
C
T
A
L
E
E
E
Site 12
S161
K
K
E
L
R
A
F
S
Q
Q
R
K
R
E
N
Site 13
S260
A
C
D
E
I
I
F
S
P
E
C
T
E
A
E
Site 14
Y290
A
S
L
G
G
Q
R
Y
V
M
R
Q
S
R
P
Site 15
Y303
R
P
H
C
C
A
C
Y
E
A
R
H
A
E
Y
Site 16
Y310
Y
E
A
R
H
A
E
Y
C
D
G
C
G
E
H
Site 17
Y327
L
D
Q
G
Q
M
A
Y
E
G
Q
H
W
H
A
Site 18
S367
I
F
C
S
R
A
C
S
L
G
S
E
P
T
A
Site 19
S370
S
R
A
C
S
L
G
S
E
P
T
A
P
G
P
Site 20
S378
E
P
T
A
P
G
P
S
R
R
S
W
S
A
G
Site 21
S381
A
P
G
P
S
R
R
S
W
S
A
G
P
V
T
Site 22
S383
G
P
S
R
R
S
W
S
A
G
P
V
T
A
P
Site 23
T409
K
G
A
S
E
T
T
T
K
G
T
S
T
E
L
Site 24
S413
E
T
T
T
K
G
T
S
T
E
L
A
P
A
T
Site 25
T414
T
T
T
K
G
T
S
T
E
L
A
P
A
T
G
Site 26
T420
S
T
E
L
A
P
A
T
G
P
E
E
P
S
R
Site 27
S437
R
G
A
P
H
R
H
S
M
P
E
L
G
L
R
Site 28
S445
M
P
E
L
G
L
R
S
V
P
E
P
P
P
E
Site 29
S453
V
P
E
P
P
P
E
S
P
G
Q
P
N
L
R
Site 30
S464
P
N
L
R
P
D
D
S
A
F
G
R
Q
S
T
Site 31
S470
D
S
A
F
G
R
Q
S
T
P
R
V
S
F
R
Site 32
T471
S
A
F
G
R
Q
S
T
P
R
V
S
F
R
D
Site 33
S475
R
Q
S
T
P
R
V
S
F
R
D
P
L
V
S
Site 34
S482
S
F
R
D
P
L
V
S
E
G
G
P
R
R
T
Site 35
T489
S
E
G
G
P
R
R
T
L
S
A
P
P
A
Q
Site 36
S491
G
G
P
R
R
T
L
S
A
P
P
A
Q
R
R
Site 37
S502
A
Q
R
R
R
P
R
S
P
P
P
R
A
P
S
Site 38
S509
S
P
P
P
R
A
P
S
R
R
R
H
H
H
H
Site 39
Y532
H
P
S
R
R
R
H
Y
Q
C
D
A
G
S
G
Site 40
S538
H
Y
Q
C
D
A
G
S
G
S
D
S
E
S
C
Site 41
S540
Q
C
D
A
G
S
G
S
D
S
E
S
C
S
S
Site 42
S542
D
A
G
S
G
S
D
S
E
S
C
S
S
S
P
Site 43
S544
G
S
G
S
D
S
E
S
C
S
S
S
P
S
S
Site 44
S546
G
S
D
S
E
S
C
S
S
S
P
S
S
S
S
Site 45
S547
S
D
S
E
S
C
S
S
S
P
S
S
S
S
S
Site 46
S548
D
S
E
S
C
S
S
S
P
S
S
S
S
S
E
Site 47
S550
E
S
C
S
S
S
P
S
S
S
S
S
E
S
S
Site 48
S551
S
C
S
S
S
P
S
S
S
S
S
E
S
S
E
Site 49
S552
C
S
S
S
P
S
S
S
S
S
E
S
S
E
D
Site 50
S553
S
S
S
P
S
S
S
S
S
E
S
S
E
D
D
Site 51
S554
S
S
P
S
S
S
S
S
E
S
S
E
D
D
G
Site 52
S556
P
S
S
S
S
S
E
S
S
E
D
D
G
F
F
Site 53
S557
S
S
S
S
S
E
S
S
E
D
D
G
F
F
L
Site 54
T583
R
P
M
P
A
Q
D
T
A
M
E
T
F
N
S
Site 55
T587
A
Q
D
T
A
M
E
T
F
N
S
P
S
L
S
Site 56
S590
T
A
M
E
T
F
N
S
P
S
L
S
L
P
R
Site 57
S592
M
E
T
F
N
S
P
S
L
S
L
P
R
D
S
Site 58
S594
T
F
N
S
P
S
L
S
L
P
R
D
S
R
A
Site 59
S599
S
L
S
L
P
R
D
S
R
A
G
M
P
R
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation